DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Napsa and Bace

DIOPT Version :9

Sequence 1:	NP_032463.1	Gene:	Napsa / 16541	MGIID:	109365	Length:	419	Species:	Mus musculus
Sequence 2:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	400	Identity:	162/400 - (40%)
Similarity:	214/400 - (53%)	Gaps:	55/400 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 LLLCLLLGNLEPEEAKLIRVPLQRIHLGHRILNPLNGWEQ---------LAELSRTSTSGGNPSF 62
            :.:.:||..|  ..|:|.|||:.:              ||         |||.|...|....||.
  Fly     5 IAVVVLLAAL--ASAELHRVPILK--------------EQNFVKTRQNVLAEKSYLRTKYQLPSL 53

Mouse    63 -----VPLSKFMNTQYFGTIGLGTPPQNFTVVFDTGSSNLWVPSTRCHFFSLACWFHHRFNPKAS 122
                 ..||..||..|:|.|.:|||.|:|.|:||:|||||||||..|.  |.||..|::::..||
  Fly    54 RSVDEEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK--SDACLTHNQYDSSAS 116

Mouse   123 SSFRPNGTKFAIQYGTGRLSGILSQDNLTIGGIHDAFVTFGEALWEPSLIFALAHFDGILGLGFP 187
            |::..||..|:||||||.|:|.||.|.:.:.|:.....||.|:..||...|..|:||||||:.:.
  Fly   117 STYVANGESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYE 181

Mouse   188 TLAVGGVQPPLDAMVEQGLLEKPVFSFYLNRDSEGSDGGELVLGGSDPAHYVPPLTFIPVTIPAY 252
            :|||.||.||...||.|||::..||||||.||...:.||||:.||||.:.|...||::|::...|
  Fly   182 SLAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGY 246

Mouse   253 WQVHMESVKVGTGLSLCAQGCSAILDTGTSLITGPSEEIRALNKAIG----GYPFLNGQYFIQCS 313
            ||..|....: .|.||| ..|.||.|||||||..|......|::.:.    ||        :.||
  Fly   247 WQFTMAGSSI-DGYSLC-DDCQAIADTGTSLIVAPYNAYITLSEILNVGEDGY--------LDCS 301

Mouse   314 KTPTLPPVSFHLGGVWFNLTGQDYVIKILQSDVGLCLLGFQALDIPKPAGPLWILGDVFLGPYVA 378
            ...:||.|:|::||..|.|....|:|   ||| |.|:..|:.:     ....|||||||:|.|..
  Fly   302 SVSSLPDVTFNIGGTNFVLKPSAYII---QSD-GNCMSAFEYM-----GTDFWILGDVFIGQYYT 357

Mouse   379 VFDRGDKNVG 388
            .||.|:..:|
  Fly   358 EFDLGNNRIG 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Napsa	NP_032463.1	pepsin_retropepsin_like	68..394	CDD:299705	142/324 (44%)
		Asp	72..396	CDD:278455	140/320 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..419
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	144/329 (44%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	140/320 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820