Protein Alignment DDX3X and DED1

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_014847.3
• Gene: DED1 / 854379
• SGDID: S000005730
• Length: 604
• Species: Saccharomyces cerevisiae
• Alignment Length: 659
• Identity: 331/659 - (50%)
• Similarity: 429/659 - (65%)
• Gaps: 68/659 - (10%)

Human    12 LDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRS 76
            |.:|...|.:|  ||...|       |:|||||.:..:.   ..:||.::::.        |..:
Yeast     4 LSEQVQNLSIN--DNNENG-------YVPPHLRGKPRSA---RNNSSNYNNNN--------GGYN 48

Human    77 DSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGD-RSGFGKFERGGNSRWCDKSDEDDWSKPL 140
            ..||..||||   :..||.:.:.|....:..|||.: |||         .||.|..     ..|.
Yeast    49 GGRGGGSFFS---NNRRGGYGNGGFFGGNNGGSRSNGRSG---------GRWIDGK-----HVPA 96

Human   141 PPSERLEQELF------SGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTR 199
            |.:|:.|..:|      :..::||||:.||||||:|:|.:.|..|..|:...:..:::.||:|.|
Yeast    97 PRNEKAEIAIFGVPEDPNFQSSGINFDNYDDIPVDASGKDVPEPITEFTSPPLDGLLLENIKLAR 161

Human   200 YTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRK 264
            :|:||||||:::||:...||||||||||||||..||.|:||:.:..||..   ..:..|.:.:||
Yeast   162 FTKPTPVQKYSVPIVANGRDLMACAQTGSGKTGGFLFPVLSESFKTGPSP---QPESQGSFYQRK 223

Human   265 QYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVD 329
            .||.::::|||||||.||::||:||:|||.|:.||||||:.||.|:|::||||.|||||||||.|
Yeast   224 AYPTAVIMAPTRELATQIFDEAKKFTYRSWVKACVVYGGSPIGNQLREIERGCDLLVATPGRLND 288

Human   330 MMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLAR 394
            ::|||||.|...|||||||||||||||||||||.|||...|.|.|.|.|:|||||||.:||.|||
Yeast   289 LLERGKISLANVKYLVLDEADRMLDMGFEPQIRHIVEDCDMTPVGERQTLMFSATFPADIQHLAR 353

Human   395 DFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLED 459
            |||.:||||:|||||||||||||||::||..||:|.|||||:|: .|.|||:|||||:.||.|.|
Yeast   354 DFLSDYIFLSVGRVGSTSENITQKVLYVENQDKKSALLDLLSAS-TDGLTLIFVETKRMADQLTD 417

Human   460 FLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEE 524
            ||..:.:..|:|||||:|.:||.||..||||.:.:|||||||||||||.||.||||:|||||:::
Yeast   418 FLIMQNFRATAIHGDRTQSERERALAAFRSGAATLLVATAVAARGLDIPNVTHVINYDLPSDVDD 482

Human   525 YVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSK 589
            ||||||||||.||.||||:|||..|.||.|.|.::|.||.|||||:|::...      |:.|...
Yeast   483 YVHRIGRTGRAGNTGLATAFFNSENSNIVKGLHEILTEANQEVPSFLKDAMM------SAPGSRS 541

Human   590 SSRFSGGFGA---RDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGN 651
            :|| .||||.   ||||::.|||:..:.|||:..:        |.|  ||.|:|....|.|:|.:
Yeast   542 NSR-RGGFGRNNNRDYRKAGGASAGGWGSSRSRDN--------SFR--GGSGWGSDSKSSGWGNS 595

Human   652 YNSQGVDWW 660
            ..|....||
Yeast   596 GGSNNSSWW 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		34/127 (27%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21		3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		34/125 (27%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		4/5 (80%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		4/8 (50%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		9/35 (26%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		307/571 (54%)
		Interaction with IKBKE	100..110		2/9 (22%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		16/38 (42%)
		DEADc_DDX3	160..410	CDD:350809	150/249 (60%)
		Q motif	180..208		10/27 (37%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		0/8 (0%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		139/255 (55%)
		SF2_C_DEAD	415..545	CDD:350174	86/129 (67%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		53/128 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		11/32 (34%)
DED1	NP_014847.3	SrmB	141..526	CDD:440279	245/388 (63%)