Protein Alignment DDX3X and ddx3xa

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: XP_021334401.1
• Gene: ddx3xa / 566947
• ZFINID: ZDB-GENE-030131-1565
• Length: 841
• Species: Danio rerio
• Alignment Length: 869
• Identity: 520/869 - (59%)
• Similarity: 575/869 - (66%)
• Gaps: 235/869 - (27%)

Human     1 MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATK--------------- 50
            ||||.|:.:.|||||.|.|||||:|.|..|:..   |||||||||::|:|
Zfish     1 MSHVVVDGSHGLDQQLAVLDLNSADGQGVGTGR---RYIPPHLRNKDASKNAGNAYSSGRQSGYS 62

Human    51 ----------------------------------------------------------------- 50
                                                                             
Zfish    63 VAPVQSFSPKQYPQSWHPEGNQRHRQNYPTGWNDFRTGNYLEKADLLLRSSICEGMVVLSALYFC 127

Human    51 ----------------------------------------------------------------- 50
                                                                             
Zfish   128 LGSQRFASQELAFYHTYTSGWPDRCASPARTDSSVATDGNEDTASVISWADRCDSPGWDGSRTNG 192

Human    51 -------------------------------------------------GFYDKDSSGWSSSKDK 66
                                                             |.|:....||:|..::
Zfish   193 FVNGYHDSRMNGTANFARGPLRNDRGGRGGFRGNRNGASFNQPVHNAGYGTYENKDGGWNSVVNR 257

Human    67 DAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKS 131
            |||:|||.||| ||||:||:|||:.||||:               :|.|||. ..||||||.::|
Zfish   258 DAYASFGGRSD-RGKSAFFNDRGASSRGRY---------------ERGGFGG-GTGGNSRWVEES 305

Human   132 -DEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNI 195
             ||:|||||:||:||||.||||..||||||||||||||||||.|.|.|||||.||:|||||||||
Zfish   306 RDEEDWSKPMPPNERLEHELFSASNTGINFEKYDDIPVEATGTNSPGHIESFHDVDMGEIIMGNI 370

Human   196 ELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMK----- 255
            .|:||||||||||:||||||.|||||||||||||||||||||:||||||:||||||:|.|
Zfish   371 TLSRYTRPTPVQKYAIPIIKTKRDLMACAQTGSGKTAAFLLPVLSQIYSEGPGEALQATKASTQQ 435

Human   256 ENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLL 320
            |||:|.||||||||||||||||||:|||:|||||:||||||||||||||||||||||||||||||
Zfish   436 ENGKYVRRKQYPISLVLAPTRELALQIYDEARKFAYRSRVRPCVVYGGADIGQQIRDLERGCHLL 500

Human   321 VATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATF 385
            |||||||||||||||||||:||||||||||||||||||||||||||||||||||.|.||||||||
Zfish   501 VATPGRLVDMMERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGSRQTMMFSATF 565

Human   386 PKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET 450
            |||||:||||||:||||||||||||||||||||||||||:|||||||||||||||||||||||||
Zfish   566 PKEIQILARDFLEEYIFLAVGRVGSTSENITQKVVWVEENDKRSFLLDLLNATGKDSLTLVFVET 630

Human   451 KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVIN 515
            |||||:||||||.|||||||||||||||||||||||||||:.||:||||||||||||||||||||
Zfish   631 KKGADALEDFLYREGYACTSIHGDRSQRDREEALHQFRSGRCPIMVATAVAARGLDISNVKHVIN 695

Human   516 FDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHY 580
            |||||||||||||||||||||||||||||:|::|.||||||||:||||||||||||||:||||.:
Zfish   696 FDLPSDIEEYVHRIGRTGRVGNLGLATSFYNDKNSNITKDLLDILVEAKQEVPSWLENLAYEHQH 760

Human   581 KGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGG--GGYGGFY 643
            |.::|||.|  |||||||||||||..| ..::|.:..|.::    ||||.:|||||  ||:|.|
Zfish   761 KSTNRGRPK--RFSGGFGARDYRQMPG-GGNTFGNRGARNT----GGHGGNRGFGGNKGGFGSF- 817

Human   644 NSDGYGGNYNSQG-----VDWWGN 662
            ..|.|||.|.:.|     ||||||
Zfish   818 GGDSYGGTYGNYGGNYTQVDWWGN 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		72/331 (22%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21		6/8 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		66/319 (21%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		5/5 (100%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		6/8 (75%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		10/34 (29%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		461/574 (80%)
		Interaction with IKBKE	100..110		0/9 (0%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		27/32 (84%)
		DEADc_DDX3	160..410	CDD:350809	226/254 (89%)
		Q motif	180..208		23/27 (85%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		6/13 (46%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		202/259 (78%)
		SF2_C_DEAD	415..545	CDD:350174	123/129 (95%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		80/131 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		12/32 (38%)
ddx3xa	XP_021334401.1	DEADc_DDX3	335..590	CDD:350809	226/254 (89%)
		SF2_C_DEAD	595..725	CDD:350174	123/129 (95%)