Protein Alignment DDX3X and Rm62

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Alignment Length: 638
• Identity: 248/638 - (38%)
• Similarity: 330/638 - (51%)
• Gaps: 88/638 - (13%)

Human    44 RNREATKGFYDKDS-------SGWSSSKDKD-AYSSFGSRSDSRGKSSFFSDR--GSGSRGRF-D 97
            |.|.....|.|.|.       .|..:..|:| .:|..|.|...||.    .||  |.|...|| .
  Fly   121 RTRTRKSLFNDPDERTEEIKIEGVMAPHDRDFGHSGRGGRGGDRGG----DDRRGGGGGGNRFGG 181

Human    98 DRGRSDYDGIGS------RGDRSGFGKFERGGNSRWCDK------SDED------DWSKPLPPSE 144
            ..|..||.||.:      |.||.|..:|  ||...:.|:      ..:|      |:|...|..:
  Fly   182 GGGGGDYHGIRNGRVEKRRDDRGGGNRF--GGGGGFGDRRGGGGGGSQDLPMRPVDFSNLAPFKK 244

Human   145 RLEQELFSGGN-TGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQK 208
            ...||..:..| :....::|.:..........|..|:.||:|.:.:.:|..|....|..||.:|.
  Fly   245 NFYQEHPNVANRSPYEVQRYREEQEITVRGQVPNPIQDFSEVHLPDYVMKEIRRQGYKAPTAIQA 309

Human   209 HAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLA 273
            ...||.....:.:..|:||||||..::||.:..|.:..|.:             |...||:||||
  Fly   310 QGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQ-------------RGDGPIALVLA 361

Human   274 PTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGL 338
            ||||||.||.:.|.:|...|.||...|:|||..|.|:|||:|||.:::||||||:|.:..|...|
  Fly   362 PTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNL 426

Human   339 DFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFL 403
            ..|.||||||||||||||||||||:||.|  :.|.  |.|:|:|||:|||::.||.|||..||.:
  Fly   427 KRCTYLVLDEADRMLDMGFEPQIRKIVSQ--IRPD--RQTLMWSATWPKEVKQLAEDFLGNYIQI 487

Human   404 AVGRVG-STSENITQKVVWVEESDK----RSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYH 463
            .:|.:. |.:.||.|.|...:|..|    ::.|.|:.:.:......::|||||:..|:|..|:..
  Fly   488 NIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRS 552

Human   464 EGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHR 528
            .|..|.:||||:||.:|:..|.:||||||.|||||.|||||||:..:|:|||||.|.:.|:|:||
  Fly   553 FGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHR 617

Human   529 IGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRF 593
            ||||||....|.:.:||.:.|....|.|:|:|.||.||:...|||:|....|.|.. ||   ||:
  Fly   618 IGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENLARNSRYDGGG-GR---SRY 678

Human   594 SGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGH-----GSSRGFGGGGYGG 641
            .||.|                     ..|.||||.     .:.|||||||.||
  Fly   679 GGGGG---------------------GGRFGGGGFKKGSLSNGRGFGGGGGGG 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		35/123 (28%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		36/128 (28%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		248/638 (39%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		2/10 (20%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		15/43 (35%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		229/571 (40%)
		Interaction with IKBKE	100..110		5/15 (33%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		5/33 (15%)
		DEADc_DDX3	160..410	CDD:350809	108/250 (43%)
		Q motif	180..208		8/27 (30%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		0/8 (0%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		101/243 (42%)
		SF2_C_DEAD	415..545	CDD:350174	61/133 (46%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		39/111 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		6/37 (16%)
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	192/454 (42%)