Protein Alignment DDX3X and abs

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_524220.1
• Gene: abs / 40530
• FlyBaseID: FBgn0015331
• Length: 619
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 186/505 - (36%)
• Similarity: 272/505 - (53%)
• Gaps: 50/505 - (9%)

Human   136 WSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRY 200
            |..|....|..|:|     ...:..|    :.:...|....|.|.||.:::..:.|:..:.....
  Fly   142 WKPPRYIREMSEEE-----REAVRHE----LRILVEGETPSPPIRSFREMKFPKGILNGLAAKGI 197

Human   201 TRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPI----LSQIYSDGPGEALRAMKENGRYG 261
            ..|||:|...:|.:...|||:..|.||||||..|:||:    |.|.||      |...:..|.||
  Fly   198 KNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEYS------LPFERNEGPYG 256

Human   262 RRKQYPISLVLAPTRELAVQIYEEARKFSYR------SRVRPCVVYGGADIGQQIRDLERGCHLL 320
                    |::.|:||||.|.:|..:.:|..      ..:|.|:..||..:.:.:..:.||.|::
  Fly   257 --------LIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVSEALDVISRGVHIV 313

Human   321 VATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATF 385
            |||||||:||:::..:.||.|:||.:||||||:|||||..:|.|....    ||.|.|::||||.
  Fly   314 VATPGRLMDMLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIFSFF----KGQRQTLLFSATM 374

Human   386 PKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET 450
            ||:||..||..|.:.:.:.|||.|:.|.|:||:|.:|::..|..:|||.|..|...  .|:|.|.
  Fly   375 PKKIQNFARSALVKPVTINVGRAGAASMNVTQQVEYVKQEAKVVYLLDCLQKTAPP--VLIFAEK 437

Human   451 KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVIN 515
            |:..|.:.::|..:|....:|||.:.|.:|..|:..:|.||..:||||.||::|||..||:||||
  Fly   438 KQDVDCIHEYLLLKGVEAVAIHGGKDQEERSRAVDAYRVGKKDVLVATDVASKGLDFPNVQHVIN 502

Human   516 FDLPSDIEEYVHRIGRTGRVGNLGLATSFFNE-RNINITKDLLDLLVEAKQEVPSWLENMAYEHH 579
            :|:|.|||.||||||||||....||||:..|: ...::..||..||:|.|||||.:|:.:|.|..
  Fly   503 YDMPDDIENYVHRIGRTGRSNTKGLATTLINKTTEQSVLLDLKHLLIEGKQEVPDFLDELAPETE 567

Human   580 YKGSSRGRSKSSRFSGGFGAR----------DYRQSSGASSSSFSSSRAS 619
            ::....|.|....:.||.|.|          ..:|:|......:.|:.|:
  Fly   568 HQHLDLGDSHGCTYCGGLGHRITECPKLEAVQNKQASNIGRRDYLSNTAA 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		2/7 (29%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		186/505 (37%)
		Interaction with IKBKE	100..110
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		5/32 (16%)
		DEADc_DDX3	160..410	CDD:350809	94/259 (36%)
		Q motif	180..208		6/27 (22%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		1/8 (13%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		87/222 (39%)
		SF2_C_DEAD	415..545	CDD:350174	60/129 (47%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		28/95 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		4/19 (21%)
abs	NP_524220.1	DEADc_DDX41	188..393	CDD:350709	85/222 (38%)
		SF2_C_DEAD	404..532	CDD:350174	60/129 (47%)