DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DDX3X and ddx3x

DIOPT Version :10

Sequence 1:NP_001347.3 Gene:DDX3X / 1654 HGNCID:2745 Length:662 Species:Homo sapiens
Sequence 2:XP_012812110.1 Gene:ddx3x / 394804 XenbaseID:XB-GENE-999731 Length:723 Species:Xenopus tropicalis


Alignment Length:733 Identity:579/733 - (78%)
Similarity:615/733 - (83%) Gaps:81/733 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREAT---------------- 49
            ||||||||.|.||||||||||||:|.||||| |:|||||||||||:||:                
 Frog     1 MSHVAVENVLSLDQQFAGLDLNSADAQSGGS-ATKGRYIPPHLRNKEASRQGYPRCQYPAVDVYK 64

Human    50 ----------------------------------------------------KGFYDKDSSGWSS 62
                                                                :||||:::|||:|
 Frog    65 GYGDWWSQRTDANWDAGRGGNGYVNGTNDDRDSRMNGYDRSGYGNRGSGRTDRGFYDRENSGWNS 129

Human    63 SKDKDAYSSFGSRSDSRGKSSFFSDR-GSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSR 126
            .:|||||||||||.: |||.|.|:|| ||||| |.|||....|||:.:||||||||:|:| ||||
 Frog   130 GRDKDAYSSFGSRGE-RGKPSLFNDRGGSGSR-RPDDRRPDGYDGMANRGDRSGFGRFDR-GNSR 191

Human   127 WCD-KSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEI 190
            |.| ::|||||||||.|::|:|||||||.||||||||||||||||||||||||||||.||.||||
 Frog   192 WSDERNDEDDWSKPLAPNDRVEQELFSGSNTGINFEKYDDIPVEATGNNCPPHIESFQDVTMGEI 256

Human   191 IMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMK 255
            |||||:|:||||||||||||||||.||||||||||||||||||||||||||||:||||:|::.:|
 Frog   257 IMGNIQLSRYTRPTPVQKHAIPIIIEKRDLMACAQTGSGKTAAFLLPILSQIYADGPGDAMKHLK 321

Human   256 ENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLL 320
            ||||||||||:|:|||||||||||||||||||||:||||||||||||||||||||||||||||||
 Frog   322 ENGRYGRRKQFPLSLVLAPTRELAVQIYEEARKFAYRSRVRPCVVYGGADIGQQIRDLERGCHLL 386

Human   321 VATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATF 385
            |||||||||||||||||||||.||||||||||||||||||||||||||||||||||.||||||||
 Frog   387 VATPGRLVDMMERGKIGLDFCNYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRQTMMFSATF 451

Human   386 PKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET 450
            |||||:|||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||
 Frog   452 PKEIQILARDFLDEYIFLAVGRVGSTSENITQKVVWVEEMDKRSFLLDLLNATGKDSLTLVFVET 516

Human   451 KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVIN 515
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   517 KKGADALEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVIN 581

Human   516 FDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHY 580
            ||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||.|:
 Frog   582 FDLPSDIEEYVHRIGRTGRVGNLGLATSFFNEKNINITKDLLDLLVEAKQEVPSWLENMAYEQHH 646

Human   581 KGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNS 645
            |.|:||||| ||||||||||||||||||||....|||...|    .|||.|||| ||||||||||
 Frog   647 KSSTRGRSK-SRFSGGFGARDYRQSSGASSGFGGSSRGGRS----SGHGGSRGF-GGGYGGFYNS 705

Human   646 DGYGGNY-NSQGVDWWGN 662
            ||||||| .|..||||||
 Frog   706 DGYGGNYGGSSQVDWWGN 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DDX3XNP_001347.3 Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090 2..139 100/206 (49%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075 12..21 8/8 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..144 89/194 (46%)
Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941 38..44 5/5 (100%)
Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487 81..90 5/9 (56%)
Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975 88..123 23/35 (66%)
Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110 100..662 501/563 (89%)
Interaction with IKBKE 100..110 3/9 (33%)
Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941 139..172 27/32 (84%)
DEADc_DDX3 160..410 CDD:350809 232/249 (93%)
Q motif 180..208 23/27 (85%)
Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication 250..259 4/8 (50%)
DEAD box 347..350 2/2 (100%)
Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544 409..662 227/253 (90%)
SF2_C_DEAD 415..545 CDD:350174 127/129 (98%)
Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238 536..661 101/125 (81%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634 19/32 (59%)
ddx3xXP_012812110.1 PRK12678 <71..>167 CDD:237171 35/97 (36%)
DEADc_DDX3 226..476 CDD:350809 232/249 (93%)
SF2_C_DEAD 481..611 CDD:350174 127/129 (98%)

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