Protein Alignment DDX3X and Ddx3x

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_001385681.1
• Gene: Ddx3x / 317335
• RGDID: 1564771
• Length: 662
• Species: Rattus norvegicus
• Alignment Length: 662
• Identity: 653/662 - (98%)
• Similarity: 657/662 - (99%)
• Gaps: 0/662 - (0%)

Human     1 MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKD 65
            |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
  Rat     1 MSHVAVENALGLDQQFAGLDLNSSDNQTGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKD 65

Human    66 KDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDK 130
            ||||||||||.|||||||||.|||||||||||||||.||||||.|||||||||||||||||||||
  Rat    66 KDAYSSFGSRGDSRGKSSFFGDRGSGSRGRFDDRGRGDYDGIGGRGDRSGFGKFERGGNSRWCDK 130

Human   131 SDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNI 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 SDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNI 195

Human   196 ELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRY 260
            ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
  Rat   196 ELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYADGPGEALRAMKENGRY 260

Human   261 GRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPG 325
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
  Rat   261 GRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPG 325

Human   326 RLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQ 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 RLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQ 390

Human   391 MLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGAD 455
            ||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||
  Rat   391 MLARDFLDEYIFLAVGRVGSTSENITQKVVWVEEIDKRSFLLDLLNATGKDSLTLVFVETKKGAD 455

Human   456 SLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPS 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 SLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPS 520

Human   521 DIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSR 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat   521 DIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAFEHHYKGSSR 585

Human   586 GRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGG 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 GRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGG 650

Human   651 NYNSQGVDWWGN 662
            ||||||||||||
  Rat   651 NYNSQGVDWWGN 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		131/136 (96%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21		8/8 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		119/124 (96%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		5/5 (100%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		7/8 (88%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		32/34 (94%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		555/561 (99%)
		Interaction with IKBKE	100..110		8/9 (89%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		32/32 (100%)
		DEADc_DDX3	160..410	CDD:350809	247/249 (99%)
		Q motif	180..208		27/27 (100%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		8/8 (100%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		250/252 (99%)
		SF2_C_DEAD	415..545	CDD:350174	128/129 (99%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		123/124 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		32/32 (100%)
Ddx3x	NP_001385681.1	DEADc_DDX3	160..410	CDD:350809	247/249 (99%)
		SF2_C_DEAD	415..545	CDD:350174	128/129 (99%)