Protein Alignment DDX3X and mahe

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_572424.1
• Gene: mahe / 31707
• FlyBaseID: FBgn0029979
• Length: 945
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 239/742 - (32%)
• Similarity: 351/742 - (47%)
• Gaps: 133/742 - (17%)

Human     8 NALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSS--SKDKDAYS 70
            ||.|:.|...|   ....|.:.......|...|.|.|.      :|.:.:.|.::  :....|.:
  Fly     9 NAGGVQQHTGG---GYYGNGAAAGAGGSGNGAPRHERQ------YYPRGNFGGAAGGAGINGAAT 64

Human    71 SFGSR--SDSRGKSSFFSDRGSGSRGRFDDRGRSDY---DGI------------GSRGDRSGFGK 118
            :.||.  ....|..::....|.| .|.....|.:.|   :|:            |..|...|:|.
  Fly    65 AAGSMHFGQPYGVMTYGIQNGLG-MGAAGSGGGNPYRQQNGVAFAGNGLGGGAGGGSGGSGGYGG 128

Human   119 FERGGNSRWCDKSDEDDWSKP----------------------LPPSERLEQELFSGGNTGINFE 161
             :||.|..:..:     :.||                      |...||.|.:.....|.|.|..
  Fly   129 -QRGKNPTYAQR-----YQKPNNGAGVAGGYQSNNYNAAALGMLSKEERAEIQREKAKNPGRNLV 187

Human   162 K-------------YD------------------DIPVEATGNNCPPHIESFSDVEMGEIIMGNI 195
            |             |:                  ::.:..:||..|..:.||.:..:...::..:
  Fly   188 KPKWENLEPFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEESSLPAHVIEEM 252

Human   196 ELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGP---GEALRAMKEN 257
            :...:|:||.:|....||....|||:..||||||||.|::||.:..|.:..|   ||.
  Fly   253 KRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEG------- 310

Human   258 GRYGRRKQYPISLVLAPTRELAVQIYEEARKFSY--RSRVRPCVVYGGADIGQQIRDLERGCHLL 320
                     ||:||||||||||.||....|.:.:  :..:|...::||:....|.|||:||..::
  Fly   311 ---------PIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVI 366

Human   321 VATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATF 385
            :||||||:|.:|.....|..|.||||||||||||||||||||:|:||  :.|.  |..:|:|||:
  Fly   367 IATPGRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQ--IRPD--RQVVMWSATW 427

Human   386 PKEIQMLARDFLDEYIFLAVGRVG-STSENITQKVVWVEESDKRSFLLDLL-------NATGKDS 442
            |||:|.||.|||::||.:.:|.:. |.:.||.|.|....|.:|...|:.||       |:....:
  Fly   428 PKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGN 492

Human   443 LTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDI 507
            ..:||||||...:.:...:..|||..||||||::|.:|:..|..||:|||.||:||.||:||||:
  Fly   493 KIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDV 557

Human   508 SNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLE 572
            .::::|||:|.|:..|.||||||||||...||.|.:||...|....::|:.:|.||.|.....|.
  Fly   558 EDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALL 622

Human   573 NMAYEHHYKGSSRGRSKSSRFSGG---FGARD--YRQSSGASSSSFSSSRASSSRSGGGGHGSSR 632
            ::|......|..||..:.:..|||   .|..:  |:|.:....:..:.:..:::|||.....|.:
  Fly   623 DLARSMPSSGGYRGNKRWNNNSGGDRNTGGNNGIYQQRNNNPLNYQAGNNYNNNRSGPPTGSSYQ 687

Human   633 GFGGGGYGGFYNSDGYGGNYNSQGVDW 659
            .:..|  |..|..:|.||     ||:|
  Fly   688 QYAAG--GNTYLQNGAGG-----GVNW 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		29/149 (19%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21		2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		27/165 (16%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		2/5 (40%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		0/8 (0%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		11/49 (22%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		220/646 (34%)
		Interaction with IKBKE	100..110		4/24 (17%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		10/85 (12%)
		DEADc_DDX3	160..410	CDD:350809	106/286 (37%)
		Q motif	180..208		5/27 (19%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		0/8 (0%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		95/264 (36%)
		SF2_C_DEAD	415..545	CDD:350174	61/136 (45%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		35/129 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		6/34 (18%)
mahe	NP_572424.1	DEAD-like_helicase_N	136..656	CDD:475120	195/544 (36%)