Protein Alignment DDX3X and sum3

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_588033.1
• Gene: sum3 / 2538689
• PomBaseID: SPCC1795.11
• Length: 636
• Species: Schizosaccharomyces pombe
• Alignment Length: 675
• Identity: 336/675 - (49%)
• Similarity: 424/675 - (62%)
• Gaps: 78/675 - (11%)

Human    24 SDN-----QSGGSTASK---------GRYIPPHLRNREATKGFYDKDSSGWSSS-KDKDAYSSFG 73
            |||     .|.||...|         .:||||..|         ||.|:|.:.: .|.::.||.|
pombe     2 SDNVQQQVDSVGSVTEKLQKTNISRPRKYIPPFAR---------DKPSAGAAPAVGDDESVSSRG 57

Human    74 SRSDSRGKSSFFSDRG-----------SGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRW 127
            | |.|:..|.|.|:.|           .|..||     :::|.|....|..:|.|.....|..:|
pombe    58 S-SRSQTPSEFSSNYGGRREYNRGGHYGGGEGR-----QNNYRGGREGGYSNGGGYRNNRGFGQW 116

Human   128 CDKSDEDDWSKPLPPSERLEQELFSG------GNTGINFEKYDDIPVEATGNNCPPHIESFSDVE 186
            .|..........|     ||::||..      .:||||||||||||||.:|.:..| :..|:...
pombe   117 RDGQHVIGARNTL-----LERQLFGAVADGTKVSTGINFEKYDDIPVEVSGGDIEP-VNEFTSPP 175

Human   187 MGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEAL 251
            :...::.||:|:.||:||||||::|||:...|||||||||||||||.||.||||..:..||. |:
pombe   176 LNSHLLQNIKLSGYTQPTPVQKNSIPIVTSGRDLMACAQTGSGKTAGFLFPILSLAFDKGPA-AV 239

Human   252 RAMKENGR-YGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLER 315
            ...::.|. |..||.||.:|:|||||||..||:||:|||.|||.||||.|||||||..|||.:::
pombe   240 PVDQDAGMGYRPRKAYPTTLILAPTRELVCQIHEESRKFCYRSWVRPCAVYGGADIRAQIRQIDQ 304

Human   316 GCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMM 380
            ||.||.||||||||:::||:|.|...|:|||||||||||||||||||.|||...|.....|.|:|
pombe   305 GCDLLSATPGRLVDLIDRGRISLANIKFLVLDEADRMLDMGFEPQIRHIVEGADMTSVEERQTLM 369

Human   381 FSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTL 445
            ||||||::||:||||||.:|:||:||||||||||||||||.||:|:|||:|||:|:....:.|||
pombe   370 FSATFPRDIQLLARDFLKDYVFLSVGRVGSTSENITQKVVHVEDSEKRSYLLDILHTLPPEGLTL 434

Human   446 VFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNV 510
            :|||||:.||:|.|:|.:..:..|||||||:||:||.||..||||::.|:||||||:|||||.||
pombe   435 IFVETKRMADTLTDYLLNSNFPATSIHGDRTQRERERALELFRSGRTSIMVATAVASRGLDIPNV 499

Human   511 KHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMA 575
            .||||:|||:||::||||||||||.||.|.|.:|||..|..|.|:|::||.||.||.||:|..||
pombe   500 THVINYDLPTDIDDYVHRIGRTGRAGNTGQAVAFFNRNNKGIAKELIELLQEANQECPSFLIAMA 564

Human   576 YEHHYKGSSRGRSKSSRFSGG---FGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGG 637
            .|..:.|:.||...|.|...|   :||||:|:.:.:||                  |.|.|....
pombe   565 RESSFGGNGRGGRYSGRGGRGGNAYGARDFRRPTNSSS------------------GYSSGPSYS 611

Human   638 GYGGFYNSDGYGGN-YNS-QGVDWW 660
            |||||.:...:.|| ||| ....||
pombe   612 GYGGFESRTPHHGNTYNSGSAQSWW 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		38/140 (27%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		39/145 (27%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		4/5 (80%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		4/19 (21%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		9/45 (20%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		306/573 (53%)
		Interaction with IKBKE	100..110		2/9 (22%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		19/38 (50%)
		DEADc_DDX3	160..410	CDD:350809	153/250 (61%)
		Q motif	180..208		10/27 (37%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		1/8 (13%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		136/257 (53%)
		SF2_C_DEAD	415..545	CDD:350174	83/129 (64%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		51/130 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		6/32 (19%)
sum3	NP_588033.1	SrmB	171..550	CDD:440279	238/379 (63%)