Protein Alignment DDX3X and laf-1

DIOPT Version :10

• Sequence 1: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_001254859.1
• Gene: laf-1 / 190611
• WormBaseID: WBGene00002244
• Length: 708
• Species: Caenorhabditis elegans
• Alignment Length: 731
• Identity: 356/731 - (48%)
• Similarity: 457/731 - (62%)
• Gaps: 113/731 - (15%)

Human    19 LDLNSSDNQSGGSTASK--GRYIPPHLRNRE-----------------ATKGFY----------- 53
            ::.|.|:|...|:.|..  |||:|||||..:                 |..|.|
 Worm     1 MESNQSNNGGSGNAALNRGGRYVPPHLRGGDGGAAAAASAGGDDRRGGAGGGGYRRGGGNSGGGG 65

Human    54 -------------DKDSSGWSSSKDKD------AYSSFGSRSDSRGKSSFFSDRGSGSRG-RFDD 98
                         |:|:.|.|....:|      .|:..|....:||   :.::||.|..| ...|
 Worm    66 GGGYDRGYNDNRDDRDNRGGSGGYGRDRNYEDRGYNGGGGGGGNRG---YNNNRGGGGGGYNRQD 127

Human    99 RGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDD------------WSK-PLPPS------- 143
            ||    ||..|...|.|:...:.|.::|...:|..:|            |:. ..|||
 Worm   128 RG----DGGSSNFSRGGYNNRDEGSDNRGSGRSYNNDRRDNGGDGQNTRWNNLDAPPSRGTSKWE 188

Human   144 ------ERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTR 202
                  ||:|||||||..:||||:||::|||||||::.|..|..|||:.:.|.|..||:...|.|
 Worm   189 NRGARDERIEQELFSGQLSGINFDKYEEIPVEATGDDVPQPISLFSDLSLHEWIEENIKTAGYDR 253

Human   203 PTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYP 267
            ||||||::||.::..||||:|||||||||||||:|:::.|..|||....|::..:|  ||:||||
 Worm   254 PTPVQKYSIPALQGGRDLMSCAQTGSGKTAAFLVPLVNAILQDGPDAVHRSVTSSG--GRKKQYP 316

Human   268 ISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGAD-IGQQIRDLERGCHLLVATPGRLVDMM 331
            .:|||:|||||::||:.|:|||:||:.:...::|||.: ...||..|..|||:|:||||||:|:|
 Worm   317 SALVLSPTRELSLQIFNESRKFAYRTPITSALLYGGRENYKDQIHKLRLGCHILIATPGRLIDVM 381

Human   332 ERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDF 396
            ::|.||::.|:||||||||||||||||||||:|||.:.||.|..|.|.|||||||||||:||:||
 Worm   382 DQGLIGMEGCRYLVLDEADRMLDMGFEPQIRQIVECNRMPSKEERITAMFSATFPKEIQLLAQDF 446

Human   397 LDE-YIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDF 460
            |.| |:||||||||||||||.||:|||||.:|||:|:|||:|||..||||||||||:||..|..:
 Worm   447 LKENYVFLAVGRVGSTSENIMQKIVWVEEDEKRSYLMDLLDATGDSSLTLVFVETKRGASDLAYY 511

Human   461 LYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEY 525
            |..:.|...:||||..|.:||:.|..||:|.:|||||||||||||||.|||||||:|||||::||
 Worm   512 LNRQNYEVVTIHGDLKQFEREKHLDLFRTGTAPILVATAVAARGLDIPNVKHVINYDLPSDVDEY 576

Human   526 VHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKS 590
            ||||||||||||:||||||||::|.||.::|:||:|||.||:|.|||.|:.:....|..|||  .
 Worm   577 VHRIGRTGRVGNVGLATSFFNDKNRNIARELMDLIVEANQELPDWLEGMSGDMRSGGGYRGR--G 639

Human   591 SRFSG-GFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGY----GGFYNSDGYGG 650
            .|.:| .||.||:|...|             |.:||||:|...||||||.    ||.:.|.|.||
 Worm   640 GRGNGQRFGGRDHRYQGG-------------SGNGGGGNGGGGGFGGGGQRSGGGGGFQSGGGGG 691

Human   651 NYNSQ------GVDWW 660
            ....|      ..|||
 Worm   692 RQQQQQQRAQPQQDWW 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		42/182 (23%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		45/200 (23%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		4/5 (80%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		1/8 (13%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		12/35 (34%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		325/600 (54%)
		Interaction with IKBKE	100..110		3/9 (33%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		23/45 (51%)
		DEADc_DDX3	160..410	CDD:350809	150/251 (60%)
		Q motif	180..208		13/27 (48%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		1/8 (13%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		149/263 (57%)
		SF2_C_DEAD	415..545	CDD:350174	90/129 (70%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		60/136 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634		9/32 (28%)
laf-1	NP_001254859.1	SrmB	233..619	CDD:440279	248/387 (64%)