DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcnq2 and KCNQ

DIOPT Version :9

Sequence 1:	XP_017171224.1	Gene:	Kcnq2 / 16536	MGIID:	1309503	Length:	937	Species:	Mus musculus
Sequence 2:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster

Alignment Length:	1043	Identity:	341/1043 - (32%)
Similarity:	464/1043 - (44%)	Gaps:	299/1043 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    29 PGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRG-WA 92
            ||.|:|.|   :|      ..|.|:|.||.....|.    :|:..||:||:.|||.|||||| .|
  Fly    22 PGRPNSER---IL------QPRMSLLGKPLNYNRGT----RRDVRYRRLQSRLYNFLERPRGLHA 73

Mouse    93 FIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGW 157
            ..||..|||:||:||.|||||||||||:.:...|:.:||:.::.|.:|:..|:|::||..||:|.
  Fly    74 IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGC 138

Mouse   158 RGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLG 222
            .|||||.::|||:|||:.::|||.||..|:.|.||||||||.|||.|||||:|||||||||||||
  Fly   139 LGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLG 203

Mouse   223 SVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQT 287
            ||||||.:||:|..|||||.||.||||||:.||..||.|..:|.|||||:|||.|:||||..|.|
  Fly   204 SVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPIT 268

Mouse   288 WNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYAT--- 349
            |.|:|:|:...|:|:|||||||||||||||||||:|.||||..:||.|||.|||:.||.||.
  Fly   269 WQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEH 333

Mouse   350 -------NLSRTDL-------------HSTWQYYERTVTVPMYSSQT-QTYGA------------ 381
                   |:.|..|             |:| .:..|..|:..:.||| ||.|.
  Fly   334 SVSVATWNIHRVALPSPPASRASSSFKHNT-SFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGS 397

Mouse   382 -------SRLIPPLN----QLELLRNLKSKSGLTFRKEPQPEPSPSKGRPCRGCLCGCCPGHSSQ 435
                   :|.|..:|    .||:::|.||.:. :|.::...|.:         ||.......:||
  Fly   398 SRASTRYTRTIRDINASVENLEVVQNGKSMNP-SFSEDSVAETT---------CLKNIKNSDASQ 452

Mouse   436 KVSLKDRVFSSPRGM----------------------------AAKGKGSPQAQTV--------- 463
            ..:|.:...||..|.                            .||..||.:..|:
  Fly   453 PATLANCKLSSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLH 517

Mouse   464 -------------RRSPSADQSLD-------------------------DSPSKVPKSWSFGDRS 490
                         |.:|:.|:.|:                         ||||..|.|      .
  Fly   518 GNFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGS------G 576

Mouse   491 RTRQAFRIKGAASRQNSEEASLPGE--DIV--EDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLV 551
            ||.:.|   .|||.......|.|..  |:.  ||...|.      .||...|.:||.:..:::.|
  Fly   577 RTGRFF---AAASHFLETGFSSPNPIIDVANEEDEPRCT------QLTNRHKTAIRFIRKLKYFV 632

Mouse   552 SKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRQEPLPVQSGHEQGPPGQNQAWHKGHQG 616
            ::|||||:|:||||.||:|||:|||:|:|.|:|.|..
  Fly   633 ARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHL---------------------------- 669

Mouse   617 LGDRIDMIVGPPPPSTPRHKKYPTKGPTAPSRESPQYSPRVDQIVGRGPTITDKDRTKGPAETEL 681
               |:|.|:|             .:|    |:....|:.::
  Fly   670 ---RLDQILG-------------KQG----SKAKDVYASKI------------------------ 690

Mouse   682 PEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPA-PPYH--SPED 743
                |:..|:.|||:||..:|:|||.|:..|.:       :.:.:...  |.|| |..|  ||..
  Fly   691 ----SLASRVVKVERQVADIEEKLDILIKAYME-------DRDRFLAL--PLPAKPKIHSISPSH 742

Mouse   744 SRDHADKHGCIIKIVRSTS--STGQRNYAAPPAIPPAQCPPSTSWQQSHQRHGTSPVGDHGSLVR 806
            ...|...:..:|.:.:.|:  |.........|.:.|:  .|.:|..:|.....|..........:
  Fly   743 KPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPS--APDSSELRSLTATQTPTTTTDAIATQ 805

Mouse   807 IPPPPAHERS--------LSAYGGGNRASTE----FLRLEGTPACRPSEAALRDSDTSISIPSVD 859
            .|.||..:.:        |::|..|:.....    ...||.    |..:........|.|.|...
  Fly   806 TPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELEN----RTKKRVTLSLHRSTSEPYSK 866

Mouse   860 HEELERSFSGFSISQSKENLDALGSCYAAVAPCAKV-----------RPYIAEGESD------TD 907
            .|:        .|:...|..|:|.|......|.:.:           .....|||.|      .|
  Fly   867 QEQ--------RITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEID 923

Mouse   908 SDL 910
            ||:
  Fly   924 SDI 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnq2	XP_017171224.1	Ion_trans	92..324	CDD:366146	148/231 (64%)
		KCNQ_channel	466..719	CDD:367540	70/281 (25%)
		KCNQ2_u3	734..821	CDD:374697	20/99 (20%)
		KCNQC3-Ank-G_bd	840..933	CDD:371819	18/88 (20%)
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	128/204 (63%)
		Ion_trans_2	221..295	CDD:285168	47/73 (64%)
		KCNQ_channel	<619..719	CDD:281513	47/175 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1387
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1251
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42770
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830