DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kcnj12 and Irk2

DIOPT Version :9

Sequence 1:	NP_034733.4	Gene:	Kcnj12 / 16515	MGIID:	108495	Length:	529	Species:	Mus musculus
Sequence 2:	NP_001287485.1	Gene:	Irk2 / 42770	FlyBaseID:	FBgn0039081	Length:	454	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	194/491 - (39%)
Similarity:	277/491 - (56%)	Gaps:	69/491 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    28 STPTLATFPWKAQEPGAEMSSQNAPRVPQPRQPSASWPRQKQHPPLQPQASAKQAHEVPPPGVSL 92
            :.||..|.|...|..|.|.::|                      ||      |:|.|..|..:.
  Fly    10 AAPTSTTIPTTTQANGGEQATQ----------------------PL------KKAIEADPDSLD- 45

Mouse    93 GAGQGPPDPGMTAASRANPYSIVSSEEDGLHLVTMSG----------ANGFGNGKVHTRRRCRNR 147
                     .:.:..::.|.:||.:.....:.::.:|          :..|..|.:   ||.|.|
  Fly    46 ---------SVISNPQSYPITIVPNRPTSYYGLSQNGKPFPRQPSCRSRNFRPGSM---RRVRRR 98

Mouse   148 FVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHG 212
            .|.|||.||:...::..:..|:|.||:||.||.:||:.||.|:|:|:.|||.|.:|:|:|...||
  Fly    99 AVFKNGDCNVVQKHLQRRRVRFLQDMYTTMVDWQWRWTLLAFALSFILSWLFFALIWWLIIYTHG 163

Mouse   213 DLEP------AEGRGRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVG 271
            |||.      .|..|..|||..:.||.:.||||||||.|||||:|..:.|||.|:||:..|||.|
  Fly   164 DLEEPHLPENQEESGWAPCVSAIDGFTSCFLFSIETQHTIGYGVRTTSPECPEAIFMMCFQSIYG 228

Mouse   272 CIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIK 336
            .:..:||.|.:.|||.|.|:||||||||.:||:..|||.|.||:|||::|||||:.|.||||||:
  Fly   229 VMSSAFMAGIVFAKMTRAKQRAQTLLFSKHAVICQRDGTLSLMFRVGDMRKSHIIGAGVRAQLIR 293

Mouse   337 PRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVIL 401
            .:.|:|||.:.....::::|.|.....:|.:.|:.|.|:|||.|||:.::..|:..|.|||||||
  Fly   294 TKSTKEGEVMTQYFTELEIGTDDSGSDLFFIWPMVIEHKIDENSPLYNLNATDMLQDKFEIVVIL 358

Mouse   402 EGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKN--QYKIDYSHFHKTYEVPSTPRCSAKDL 464
            ||.||:|..:|||||||:..||||||||:||:...|:  .|:|||:.|::|.:| .||.|||::|
  Fly   359 EGTVESTGQSTQARSSYINTEILWGHRFDPVVLYNKDLQAYEIDYARFNETTQV-DTPLCSAREL 422

Mouse   465 -----VENKFLLPSANSFCYENELAFLSRDEEDEVA 495
                 ::..|..|:..:|....    ||.:..|:.:
  Fly   423 NEIYKIQEGFRTPAETTFTMRQ----LSHNHSDQAS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnj12	NP_034733.4	PRK07764	<9..111	CDD:236090	14/82 (17%)
		IRK_N	104..148	CDD:369890	9/53 (17%)
		IRK	149..289	CDD:366415	70/145 (48%)
		IRK_C	296..468	CDD:375232	88/178 (49%)
Irk2	NP_001287485.1	IRK	100..434	CDD:279361	165/334 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3119
eggNOG	1	0.900	-	-		E1_KOG3827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7793
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2162
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59160
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8723
orthoMCL	1	0.900	-	-		OOG6_101017
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880