DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kcnj10 and Irk3

DIOPT Version :9

Sequence 1:	XP_006496740.3	Gene:	Kcnj10 / 16513	MGIID:	1194504	Length:	476	Species:	Mus musculus
Sequence 2:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	123/427 - (28%)
Similarity:	202/427 - (47%)	Gaps:	83/427 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    23 KQDPT-DFPCLGGMDSISPACAHIPWGGGSIYLCGSYVSDISQILSTAPCTLSACAHLYSSVAGL 86
            :|:|| .||           .|| .|.|.:|        :::..|.:.|.|.|
  Fly    75 EQNPTFSFP-----------YAH-DWAGSTI--------ELTPDLGSGPRTSS------------ 107

Mouse    87 GLKESDWQKTQMTSVAKVYYSQTTQTESRPLVAPGIRR--RRVLTKDGRSNVRMEHIADKRFLYL 149
                ||                            |:||  .||:.|:|:.||....|.:|.:.|:
  Fly   108 ----SD----------------------------GLRRSLNRVMEKNGKENVVFRRIPEKSWRYM 140

Mouse   150 KDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLL-------ELGPPANHTPCVV 207
            :||.||.::::|:|.|.||..::..:|.||..:.|:||.:|||.:       .:|...:  ||:.
  Fly   141 RDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVD--PCIY 203

Mouse   208 QVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKR 272
            .||:.....::|:|:|||:|:|.:|.|||||..|.|.:.|::...::|..:.....||.|||.::
  Fly   204 GVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQ 268

Mouse   273 AETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQV 337
            ...::||..||:...:|:.||:.||.:.|:...|..::...::...:|:|||.|: :.|.:..:
  Fly   269 LTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIK-SHVELKLE- 331

Mouse   338 DTASDSPFLILPLTFYHVVDETSPLKDLPLRS--GEGDFELVLILSGTVESTSATCQVRTSYLPE 400
              .:....::.|....||:||||||.......  ....|||.:.:.||..:|:...:.:|||||.
  Fly   332 --GNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPR 394

Mouse   401 EILWGYEFTPAISLSASG-KYIADFSLFDQVVKVASP 436
            ||.||..|...|...|.. :||.|:..|::.:.|..|
  Fly   395 EIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnj10	XP_006496740.3	IRK	129..269	CDD:366415	50/146 (34%)
Kcnj10	XP_006496740.3	IRK_C	276..451	CDD:375232	50/164 (30%)
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	102/319 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950