DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADGRF3 and mthl12

DIOPT Version :9

Sequence 1:	NP_001138640.1	Gene:	ADGRF3 / 165082	HGNCID:	18989	Length:	1079	Species:	Homo sapiens
Sequence 2:	NP_731791.2	Gene:	mthl12 / 261599	FlyBaseID:	FBgn0045442	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	309	Identity:	58/309 - (18%)
Similarity:	111/309 - (35%)	Gaps:	86/309 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   768 PALALLTQVGLGASILALLVCLGVYW---LVWRVVVRNKISYFRHAALLNM-VFCLLAADTCFLG 828
            |.:|.|:.:.:...||.|.|.|.|..   |:.:.::.:..|.|....:..| .|.||.:
  Fly   215 PGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEYFIWTMDYFRLLQS------ 273

Human   829 APFLSPGPRSPLCLAAAFLCHFLYLATFFWMLAQALVLAHQLLFVFHQLAKHRVLPLMVLLGY-- 891
                       :|.||.::.:|..::::.|.    .|::..|..:|..|.:|.  |....|.|
  Fly   274 -----------ICSAAGYMKYFFSMSSYLWF----SVVSFHLWELFTSLNRHE--PQYRFLIYNT 321

Human   892 --LCPLGLAGVTL-------------GLYLPQGQYLR------EGECWLDGKGGALYTFVGPVLA 935
              .|...:..|.:             ..:||...|..      ....|       .|:.: |::.
  Fly   322 FVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVGYFGCSVKDWNSSSW-------FYSHI-PIVI 378

Human   936 IIGVNGLVLAMAMLKL--LRPSLSEGPPAEKR---------QALLGVIKALLILTPIFGLTWGLG 989
            :...|.::..:..:.:  ::..:......::|         |..:..::..||:    |.:|.|.
  Fly   379 LNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIM----GASWLLD 439

Human   990 LATLLEE-----VSTVPHYIFTILNTLQG--VFILL------FGCLMDR 1025
            ..|.|.|     :.|:...:...||...|  :|:||      |..:|:|
  Fly   440 QLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRF3	NP_001138640.1	HRM	431..477	CDD:280888
		GPS	713..758	CDD:280071
		7tm_4	770..1016	CDD:304433	51/290 (18%)
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810