DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kcnb1 and Shawl

DIOPT Version :9

Sequence 1:NP_032446.2 Gene:Kcnb1 / 16500 MGIID:96666 Length:857 Species:Mus musculus
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:979 Identity:249/979 - (25%)
Similarity:365/979 - (37%) Gaps:320/979 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    32 RVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDC-NTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSI 95
            |:.|||.|:.:|....||.::|.|||.:|.:. ..:|.:|          ||||||||||.||.|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGVFTQI 60

Mouse    96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELKREAETL 155
            ||:||||:||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|..
  Fly    61 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP 125

Mouse   156 RERE-------GEEFDN---TCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNT 210
            .|.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|
  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190

Mouse   211 LPELQ------SLDEFGQSTDNPQLAH-------------------------------------- 231
            .|..:      :.|..|.....|...|                                      
  Fly   191 HPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSS 255

Mouse   232 ----------------------------------------------------------------V 232
                                                                            |
  Fly   256 GNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYV 320

Mouse   233 EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQ 297
            |.||..||.:|.::|.:.||..|:|.|.|:|.||..|.|.:|..:        :.:......:::
  Fly   321 ELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLE 377

Mouse   298 IFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDDTK 360
            .|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |..|.:
  Fly   378 AFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQ 442

Mouse   361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QK 424
            |||||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.
  Fly   443 FKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQA 507

Mouse   425 RQEKAIKRREAL----ERAKRN------------------------GSIVSMN------------ 449
            |.:...|||..|    .|.||.                        |.:|.:.            
  Fly   508 RSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAVG 572

Mouse   450 --------MKDAF-ARSIEMMDIVVEKNGEGVAKKDKVQ-------------------------- 479
                    .|||| ...|..:::    ||..|......|                          
  Fly   573 HSAAGAPMFKDAFGGAKIGTVNV----NGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVP 633

Mouse   480 ---------DNH---------LSPNKWKWTKRA-LSETSSSKSFETKEQGSPEKARSSSSPQHLN 525
                     .:|         |.|.....|..| |:.:::|.:..|....:| ...|..|..:|:
  Fly   634 MLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAAAAAP-AGPSFISSDYLS 697

Mouse   526 VQQLQDMYSKMAKTQSQPILNTKEMAPQSQPQEELEMGSMPSPVAPLPTRTEGVIDMRSMSSIDS 590
            |..:|.:..:.|.|                 ..:..:...|..:.||..:.:..:.:.:.     
  Fly   698 VPAVQSLQPRAATT-----------------GHDFMLPLQPKLLGPLERKDQHPLQLTAH----- 740

Mouse   591 FISCATDFPEATRFSHS----------------PLASLSG-------KSGGSTAPEVGWRGALGA 632
              :.|:|..:.....|:                |..|:|.       .|.|...|.:.:|.|.||
  Fly   741 --NLASDTHQLMYSGHAHSQHKVGGGAAVLNVPPTLSMSHTQMPPGIASMGQRTPNLSFRPAHGA 803

Mouse   633 SGGRLMETNPIPEASRSGFFVESPRSSMKTHNPMKLRALKVNFLEGDP----TPLLPALGLYHDP 693
            |........|||         .|......|:..:|:.........|.|    ||.:..|    |.
  Fly   804 SSQVATVQQPIP---------HSHACHASTNCNIKISVASAGLSVGCPDEFRTPKVTLL----DD 855

Mouse   694 LRNRGGAAAAVAGLECASLLDKPVLSPESSIYTTASARTPPRSPEKHTAIAFNFEAGVHQYIDTD 758
            |.:...::....| :|. |:|      :|..|...:....|...|..|. |...:.|:   :|.|
  Fly   856 LSDDVNSSTDDCG-DCC-LVD------DSDTYEGTTINNGPSGQENGTE-AIGLDDGL---LDND 908

Mouse   759 TDDE 762
            .:||
  Fly   909 GEDE 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kcnb1NP_032446.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
BTB_POZ_KCNB2 15..141 CDD:349719 47/109 (43%)
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 59..75 3/16 (19%)
Ion_trans 188..424 CDD:366146 108/346 (31%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 377..382 4/4 (100%)
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 448..481 9/88 (10%)
Kv2channel 467..678 CDD:367541 43/278 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..569 18/138 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 608..627 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..857
ShawlNP_001097131.2 BTB 7..99 CDD:197585 44/101 (44%)
BTB_2 7..97 CDD:280393 43/99 (43%)
Ion_trans 307..506 CDD:278921 92/206 (45%)
Ion_trans_2 <449..499 CDD:285168 32/49 (65%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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