DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AEBP1 and svr

DIOPT Version :9

Sequence 1:	NP_001120.3	Gene:	AEBP1 / 165	HGNCID:	303	Length:	1158	Species:	Homo sapiens
Sequence 2:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster

Alignment Length:	831	Identity:	217/831 - (26%)
Similarity:	339/831 - (40%)	Gaps:	202/831 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   183 LPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDF 247
            |.|..:|....|.|||......|:...|...:::...              |:.|::|:.....
  Fly   139 LVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNR--------------DFPDRLEQSHVHQ- 188

Human   248 EYIRRQKQPRPPPSRRRRPERV----WPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVI 308
              :|.|.         |:||..    |...                  ||.:  |..::..|.|:
  Fly   189 --LRAQS---------RQPETAALVNWIVS------------------KPFV--LSANFHGGAVV 222

Human   309 PNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKD-HKEPRKGEE 372
            .:|          |.....|..:..|          |..:|.:...|.......| |...|||..
  Fly   223 ASY----------PYDNSLAHNECCE----------ESLTPDDRVFKQLAHTYSDNHPIMRKGNN 267

Human   373 LEEEWTP----------------------------TEKVKCPPIGMESHRIEDNQIRASSMLRHG 409
            ..:.::.                            |.::.|......|...::.|...:|:|:..
  Fly   268 CNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLL 332

Human   410 LGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRRTTR---FTGVITQGRDSSIHDDFV 471
            ..|..|...:.|.|:      |...|:.:.....:|....||::   :..::|.|. .|:|   .
  Fly   333 RQAHIGIKGLVTDAS------GFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGL-YSVH---A 387

Human   472 TTFFVGFSNDSQTWVMYTNGYE------------EMTFHGNVDKDTPVLSELPEPVVARFIRIYP 524
            :.|  |:...:...|..||..:            |..|.||..|.....||.|:.:..:|
  Fly   388 SAF--GYQTSAPQQVRVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKLKKQF----- 445

Human   525 LTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYS 589
               ||.|           .|.               .:.||::..|...::.::...|::||.||
  Fly   446 ---NGFL-----------TPT---------------KYEHHNFTAMESYLRAISSSYPSLTRLYS 481

Human   590 LGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGN-PRV 653
            :|||.:|..::.:||...||.|..|.|||:|.|.:|||||:|:||||:|.:|:...|  || .|:
  Fly   482 IGKSVQGRDLWVLEIFATPGSHVPGVPEFKYVANMHGNEVVGKELLLILTKYMLERY--GNDDRI 544

Human   654 RSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWV 718
            ..||..||:|.:.|:||||||::.: |...|  .:|.....|.|:..:|||    .:|.
  Fly   545 TKLVNGTRMHFLYSMNPDGYEISIE-GDRTG--GVGRANAHGIDLNRNFPD----QYGT------ 596

Human   719 PYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQ 783
                        :|:   :.....||.|::.|....||||.|||:||..:.:||:|.......:.
  Fly   597 ------------DRF---NKVTEPEVAAVMNWTLSLPFVLSANLHGGSLVANYPFDDNENDFNDP 646

Human   784 LLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRG-GCQA-QDYTGGMGIV 846
            .:....::..|.      :...|.|:|:|:.||..:::||.|:   |.| .|:. |:.....||.
  Fly   647 FMRLRNSSINGR------KPNPTEDNALFKHLAGIYSNAHPTM---YLGQPCELFQNEFFPDGIT 702

Human   847 NGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGV 911
            |||:|...||.:.|::|:...||||:..:||||||..:||.|.||:::|.||.|:||||.||.|.
  Fly   703 NGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREPLLQFIEQVHCGIHGF 767

Human   912 VTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTP 962
            |....|.|||.|.:.:.|.||...:...||||::..||.:.:|...:.|.|
  Fly   768 VHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYAP 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AEBP1	NP_001120.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..387		37/236 (16%)
		FA58C	384..540	CDD:214572	35/170 (21%)
		FA58C	386..539	CDD:238014	34/167 (20%)
		Required for DNA-binding and interaction with NFKBIA. /evidence=ECO:0000250	390..555		35/179 (20%)
		Interaction with MAPK1 and MAPK3. /evidence=ECO:0000250	421..624		52/217 (24%)
		Interaction with PTEN. /evidence=ECO:0000250	555..985		145/411 (35%)
		M14_CPX_like	560..903	CDD:199851	120/345 (35%)
		Peptidase_M14NE-CP-C_like	907..982	CDD:200604	21/56 (38%)
		Required for transcriptional repression. /evidence=ECO:0000250	941..1158		8/22 (36%)
		Interaction with MAPK1 and MAPK3. /evidence=ECO:0000250	1006..1158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1108..1141
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	41/260 (16%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	17/89 (19%)
		M14_CP_N-E_like	456..759	CDD:199842	120/341 (35%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	21/56 (38%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10468
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11532
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920