Protein Alignment Kcna6 and Shab

DIOPT Version :9

• Sequence 1: NP_038596.1
• Gene: Kcna6 / 16494
• MGIID: 96663
• Length: 529
• Species: Mus musculus
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 474
• Identity: 164/474 - (34%)
• Similarity: 240/474 - (50%)
• Gaps: 115/474 - (24%)

Mouse    40 SERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVR-------------FFDPLRNEYFFDRNRP 91
            :.|:.||:.|:|.|...|||...|.|.||    |:|             .:....|||||||:..
  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPK 366

Mouse    92 SFDAILYYYQSGGRLRRPVNVPLDIFMEEIRFY------------------------QLGEEALA 132
            ||.:||.:|:: |:|.....:.:..|.:::.::                        ::.:||.:
  Fly   367 SFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAES 430

Mouse   133 AFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLP 197
            ..:.||....||...|       :|:.:|.|.|.|.:|..||.||::|:|.|::|.:...|.|||
  Fly   431 LRQRDEEEFGEGKCAE-------YQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP 488

Mouse   198 QFRADGRGGSNEGSGTRLSPASRSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSLSTLGGSFFTDP 262
            |.:                     |.:....:|:                             ..
  Fly   489 QLQ---------------------HIDNGTPQDN-----------------------------PQ 503

Mouse   263 FFLVETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFIT---LGTELVQRHEQQSV 324
            ..:||.:||.|||.|.::||||.|.|..||:..:|||||:||.|||::   |.|......:.|.|
  Fly   504 LAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDV 568

Mouse   325 SGGSGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVIL 389
            .             .:::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||.:||::
  Fly   569 R-------------RVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLI 620

Mouse   390 FSSAVYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPV 454
            |||..||||.|:.|:.|.|||:.||||.:|||||||||:||.|..||::|::|.|.|||.||||:
  Fly   621 FSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPI 685

Mouse   455 PVIVSNFNYFYHRETEQEE 473
            |:||:||..||..:..:|:
  Fly   686 PIIVNNFAEFYKNQMRREK 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kcna6	NP_038596.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35
		BTB_POZ_KCNA6	41..170	CDD:349714	42/165 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..238		2/34 (6%)
		Ion_trans	258..468	CDD:366146	105/212 (50%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	360..373		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	422..427		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..513
		PDZ-binding. /evidence=ECO:0000255	527..529
Shab	NP_001189037.1	BTB	309..416	CDD:197585	29/111 (26%)
		BTB_2	309..408	CDD:280393	29/103 (28%)
		Ion_trans	501..700	CDD:278921	105/240 (44%)
		Ion_trans_2	613..696	CDD:285168	50/82 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810