DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcna5 and Shab

DIOPT Version :9

Sequence 1:	NP_666095.1	Gene:	Kcna5 / 16493	MGIID:	96662	Length:	602	Species:	Mus musculus
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	608	Identity:	196/608 - (32%)
Similarity:	288/608 - (47%)	Gaps:	150/608 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 GGGEAGASCVQSPRGECGCPPTAGLNNQSKETSPRRRATHEDAGQGGRPLPPMPQELPQPRRPSA 82
            ||...|.:..||..|  |.|    .::||..|...:| || .......| ||.|..:.|.:..::
  Fly   252 GGVGVGGASSQSISG--GVP----THSQSNTTGALQR-TH-SRSMSSIP-PPEPFMIAQSKAVNS 307

Mouse    83 EDEEGEGDPGLGTVEEDQAPQDSGSLHHQRVLINISGLRFETQLGTLAQFPNTLLGDPVKRLRY- 146
                                         ||.||:.|:|.|....||.:.|:|.||    |||.
  Fly   308 -----------------------------RVSINVGGVRHEVLWRTLERLPHTRLG----RLREC 339

Mouse   147 ------------FDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEI-------- 191
                        :....|||||||:..||..||.:|:: |:|.....:.:..|:|::
  Fly   340 TTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDEL 403

Mouse   192 --------RFYQLGDEAMERFR-EDEGFIKEEEKPLPRN---EFQRQVWLIFEYPESSGSARAIA 244
                    :::|..:...|..| |.|...:.:|:.....   |:|:.:|.:.|.|.:|.:||.||
  Fly   404 YLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIA 468

Mouse   245 IVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGANGSGSGVLSSGPTVAPLLPR 309
            ::|:|.|::|.|...|.|||:       |:|                ..:|.....|.:|
  Fly   469 VISILFIVLSTIALTLNTLPQ-------LQH----------------IDNGTPQDNPQLA----- 505

Mouse   310 TLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITLGTELAEQQPGG 374
                   :||..|:.|||.|.::||.|.|.|.:|.:..:||||::||.|||::|......:....
  Fly   506 -------MVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATD 563

Mouse   375 GGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSS 439
            ..|:.::     :::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||.:||::|||
  Fly   564 QFQDVRR-----VVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS 623

Mouse   440 AVYFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVI 504
            ..||||.|.:.:.|.|||:.||||.:|||||||||:.|.|..||::|::|.|.|||.||||:|:|
  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688

Mouse   505 VSNFNYFYHRETDHEEQAALKEEQGIQR--RESGL-----------------------DTGGQRK 544
            |:||..||..:...|:  |||..:.:.|  ||..:                       |||.|..
  Fly   689 VNNFAEFYKNQMRREK--ALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTN 751

Mouse   545 VSCSKASFCKTGGPLESTDSIRR 567
            |...|       |..:||.:|.|
  Fly   752 VVHPK-------GKRQSTPNIGR 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcna5	NP_666095.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		19/88 (22%)
		BTB	113..207	CDD:197585	34/123 (28%)
		BTB_2	113..204	CDD:280393	33/119 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..297		2/22 (9%)
		Ion_trans	305..515	CDD:278921	97/209 (46%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	407..420		7/12 (58%)
		Ion_trans_2	429..506	CDD:285168	45/76 (59%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	469..474		4/4 (100%)
		PDZ-binding	600..602
Shab	NP_001189037.1	BTB	309..416	CDD:197585	31/111 (28%)
		BTB_2	309..408	CDD:280393	31/103 (30%)
		Ion_trans	501..700	CDD:278921	99/215 (46%)
		Ion_trans_2	613..696	CDD:285168	48/82 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810