DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kcna4 and Shawl

DIOPT Version :9

Sequence 1:NP_067250.2 Gene:Kcna4 / 16492 MGIID:96661 Length:654 Species:Mus musculus
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:525 Identity:178/525 - (33%)
Similarity:249/525 - (47%) Gaps:147/525 - (28%)


- Green bases have known domain annotations that are detailed below.


Mouse   178 RVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 242
            |:::||||:|:||...||.:.|.|.|....:....:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

Mouse   243 KRPVNVPFDIFTEEVKFYQLGEE--------------------ALLKFREDEGFVREEE------ 281
            ..|.:|...:|.||::|:.|...                    |:|...:.|.....||      
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

Mouse   282 --DRALPENE------FKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRD 338
              :.||...|      .|.:||.:|:.|.||:.|:.:|.:||..|.:|::.|||:|.|.||.|  
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVD-- 197

Mouse   339 LIMALSAGGHS-----------------------------------------RLLNDT--SAPHL 360
                |.:|.|.                                         |:.|.|  |:.:.
  Fly   198 ----LPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNF 258

Mouse   361 ENSGH---------------------TIFN--------------------------DPFFIVETV 378
            ..||.                     :|.|                          :.||.||.|
  Fly   259 TASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELV 323

Mouse   379 CIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAI 443
            |.|||..|.::|....|:...|.|:.:||||..:.|.::    ||:.|:.|...|         :
  Fly   324 CNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG---------L 375

Mouse   444 LRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAE--ADEPT 506
            |....:||:.|:|||:|||.||:||.||.:||.:||.||:|||.:|::.|:|..|:||  .|.|.
  Fly   376 LEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPD 440

Mouse   507 THFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HR 570
            ..|:|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||||||:.|| |.
  Fly   441 NQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHT 505

Mouse   571 ETENE 575
            :..::
  Fly   506 QARSK 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kcna4NP_067250.2 K_channel_TID 1..>37 CDD:369607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..145
BTB_POZ 177..304 CDD:365784 49/159 (31%)
Ion_trans 307..571 CDD:366146 127/356 (36%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 463..476 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 525..530 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..654
PDZ-binding. /evidence=ECO:0000250 652..654
ShawlNP_001097131.2 BTB 7..99 CDD:197585 35/92 (38%)
BTB_2 7..97 CDD:280393 35/90 (39%)
Ion_trans 307..506 CDD:278921 102/211 (48%)
Ion_trans_2 <449..499 CDD:285168 37/49 (76%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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