DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcna4 and Shab

DIOPT Version :9

Sequence 1:	NP_067250.2	Gene:	Kcna4 / 16492	MGIID:	96661	Length:	654	Species:	Mus musculus
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	195/635 - (30%)
Similarity:	285/635 - (44%)	Gaps:	167/635 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 HMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTG-------------GSGGG------- 60
            |:.||.............|.:..:.|.|.|.|.|:|.|:|             |||.|
  Fly   163 HLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEVR 227

Mouse    61 --------PHHHHQTR-------------GAYSSHD-----PQGSRGSRRRRRQRTEKKKLHHRQ 99
                    |.|...|.             |..||..     |..|:.:.....|||..:.:
  Fly   228 YAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSM---- 288

Mouse   100 SSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGG 164
            ||.|.....|.:.|:
  Fly   289 SSIPPPEPFMIAQSK-------------------------------------------------- 303

Mouse   165 GGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQY---------FDPLRNEY 220
                :|.     .||.|||.|:|.|...:||.:.|.|.||...:.|.:         :....|||
  Fly   304 ----AVN-----SRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEY 359

Mouse   221 FFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEV----------------KFYQLGEEALLK 269
            ||||:..||.:||.:|:: |:|.....:....|::::                |::|..|....:
  Fly   360 FFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEE 423

Mouse   270 FREDEGFVREEEDRALPEN---EFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLP 331
            .|::...:|:.::....|.   |::|.:|.|.|.|.:|..||.||::|:|.|::|.:...|.|||
  Fly   424 MRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP 488

Mouse   332 EFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPS 396
            :.:                        |::| |....|....:||.|||.||:.|:::|..|.|.
  Fly   489 QLQ------------------------HIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPD 528

Mouse   397 QALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRH 461
            :..|||..:||||:::|||||::|  .|.:.......|.|...  .::::.|::|:.||.||:||
  Fly   529 KWKFFKGGLNIIDLLAILPYFVSL--FLLETNKNATDQFQDVR--RVVQVFRIMRILRILKLARH 589

Mouse   462 SKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTV 526
            |.|||.||.|||.|.:|||||:.||.:||::|||..||||.||..|.|.|||:.||||.:|||||
  Fly   590 STGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTV 654

Mouse   527 GYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEE 576
            ||||:.|.|..||::|::|.|.|||.||||:|:||:||..||..:...|:
  Fly   655 GYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcna4	NP_067250.2	K_channel_TID	1..>37	CDD:369607	4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..145		29/166 (17%)
		BTB_POZ	177..304	CDD:365784	42/154 (27%)
		Ion_trans	307..571	CDD:366146	118/263 (45%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	463..476		8/12 (67%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	525..530		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..654
		PDZ-binding. /evidence=ECO:0000250	652..654
Shab	NP_001189037.1	BTB	309..416	CDD:197585	30/107 (28%)
		BTB_2	309..408	CDD:280393	29/99 (29%)
		Ion_trans	501..700	CDD:278921	103/202 (51%)
		Ion_trans_2	613..696	CDD:285168	50/82 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810