DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kcna2 and Shab

DIOPT Version :10

Sequence 1:NP_032443.3 Gene:Kcna2 / 16490 MGIID:96659 Length:499 Species:Mus musculus
Sequence 2:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster


Alignment Length:481 Identity:175/481 - (36%)
Similarity:262/481 - (54%) Gaps:90/481 - (18%)


- Green bases have known domain annotations that are detailed below.


Mouse    34 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRY-------------FDPLRNEYFFDRNRPSF 85
            ||.||:.|:|.|...:||.:.|.|.||    |:|.             :....|||||||:..||
  Fly   308 RVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPKSF 368

Mouse    86 DAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAM-----------------EMFREDEGYI 133
            .:||.:|:: |:|.....:.:..||:::.::.:.|..:                 ||.:|.|...
  Fly   369 SSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLR 432

Mouse   134 KEEERPLPEN---EFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDM 195
            :.:|....|.   |:|:.:|.|.|.|.:|..||:||::|::.|::|.::..|.|||    :.:.:
  Fly   433 QRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP----QLQHI 493

Mouse   196 HGGGVTFHTYSNSTIGYQQSTSFTDP-FFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259
            ..|                 |...:| ..:||.:||.||:.|:::||.|.|.|..||...:||||
  Fly   494 DNG-----------------TPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIID 541

Mouse   260 IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKAS 324
            ::||:|||::|  .|.|..::|....|.:. .:::|.|::|:.||.||:|||.|||.||.||:.|
  Fly   542 LLAILPYFVSL--FLLETNKNATDQFQDVR-RVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603

Mouse   325 MRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKI 389
            .:|||||:.||.:||::|||..||||.||:|::|.|||:.||||.::||||||||:.|||..||:
  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668

Mouse   390 VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTIS 454
            :|::|.|.|||.||||:|:||:||..||..:...|:..                  |.|.|...:
  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKAL------------------KRREALDRA 715

Mouse   455 KSDYMEIQEGVNNSNEDFREENLKTA 480
            |      :||   |...|...|||.|
  Fly   716 K------REG---SIVSFHHINLKDA 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kcna2NP_032443.3 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142 1..125 32/120 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
BTB_POZ 33..159 CDD:453885 44/157 (28%)
Ion_trans 162..420 CDD:459842 117/258 (45%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 312..325 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142 497..499
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720 32/110 (29%)
Ion_trans 464..700 CDD:459842 117/259 (45%)
Blue background indicates that the domain is not in the aligned region.

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