DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kcna1 and Shawl

DIOPT Version :9

Sequence 1:NP_034725.3 Gene:Kcna1 / 16485 MGIID:96654 Length:495 Species:Mus musculus
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:550 Identity:167/550 - (30%)
Similarity:255/550 - (46%) Gaps:149/550 - (27%)


- Green bases have known domain annotations that are detailed below.


Mouse    38 RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 102
            |:::|:||:|:||...||.:.|.|.|....:.:..:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

Mouse   103 RRPVNVPLDMFSEEIKFYELGEEAMEK--------FREDEGFIK-------EEERPLPEKE---- 148
            ..|.:|...:|.||::|:.|....:|.        .|:.:..:.       |.|:|..|:.    
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

Mouse   149 -------------YQR---QVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD-- 195
                         :||   ::|.:|:.|.||..|:::|.:||..|.:|::.|||:|.|..:.|  
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199

Mouse   196 --------------------------------------KDFTGTIHRIDNTTVIYTSNIFT---- 218
                                                  ....|...|:.|.| .|:|..||    
  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYT-SYSSGNFTASGQ 263

Mouse   219 ---------------------------------------------------DPFFIVETLCIIWF 232
                                                               :.||.||.:|.:||
  Fly   264 ATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWF 328

Mouse   233 SFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLV 297
            ..|:::|....|:...|.|:.:|.||..|.:.::    |::.::.|...|       :|....:|
  Fly   329 FIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG-------LLEAFSIV 382

Mouse   298 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--AEEAESHFSSIP 360
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .:..::.|.|||
  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447

Mouse   361 DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETEG--- 421
            ...|||:|:||||||||:.|.|..|..||:|||:|||||||||||||||||:.|| |.:...   
  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLP 512

Mouse   422 EEQAQLLHVSSPNLASDSDLSRRSSSTISK 451
            :::.::|.|..|....:.....|..:...|
  Fly   513 KKRRRVLPVEQPRRKREPTAPHRGRTNAIK 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kcna1NP_034725.3 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 35/89 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
BTB_POZ 37..163 CDD:365784 46/159 (29%)
Ion_trans 166..418 CDD:366146 114/349 (33%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495
ShawlNP_001097131.2 BTB 7..99 CDD:197585 35/92 (38%)
BTB_2 7..97 CDD:280393 35/90 (39%)
Ion_trans 307..506 CDD:278921 94/209 (45%)
Ion_trans_2 <449..499 CDD:285168 36/49 (73%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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