DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jup and p120ctn

DIOPT Version :9

Sequence 1:	NP_034723.1	Gene:	Jup / 16480	MGIID:	96650	Length:	745	Species:	Mus musculus
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	107/533 - (20%)
Similarity:	179/533 - (33%)	Gaps:	194/533 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse   223 FKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
            ::...:..::..||:|..::...|...|.:|....:..|...|...|:..:|.||:.::|:....
  Fly   222 WRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKN 286

Mouse   288 TTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAG 352
            ....|:.|:||.|..:                                        ||..|..||
  Fly   287 ACGALRNLSYGRQNDE----------------------------------------NKRGIKNAG 311

Mouse   353 GMQALGKHLTSNS-----PRLVQNCLWTLRNLSDVATK--QEGLESVLKILVNQLSVDDV----- 405
            |:.|| .||...|     ..||...||.:.:..|:...  .|.|.:|:..::...|..|.
  Fly   312 GIAAL-VHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGE 375

Mouse   406 ----NVLTCATGTLSNL-TCNNSKNKTLVTQNSGVEALIHAILRAGDKDDI----TEPAVCALRH 461
                .|...|:|.|.|: :........|......||.|::.:..:.:|::|    .|..||.||:
  Fly   376 TCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRN 440

Mouse   462 LTSR-----------HP----------------------------------------EAEMAQNS 475
            |:.|           ||                                        .|:.:::|
  Fly   441 LSYRCQEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSS 505

Mouse   476 V---RLNYGI-----PAIVK----LLNQPNQWPLVKATIGLIRNLALC---PA--NHAPLQEAAV 523
            |   :||.|.     |.:|:    ||...:....::|..|.|:||:.|   |:  ..|.:::...
  Fly   506 VTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKG 570

Mouse   524 IPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRME--EIVEGCTGALHILARDPMNRMEIFRLNTI 586
            :|.||:||                       |||  .:|.....||..||.|..|:..|.:
  Fly   571 LPILVELL-----------------------RMEVDRVVCAVATALRNLAIDQRNKELIGK---- 608

Mouse   587 PLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFR 651
                   |:..:.:|::.:|                         .:.|.:|....| ..|||..
  Fly   609 -------YAMRDLVQKLPSG-------------------------NVQHDQNTSDDT-ITAVLAT 640

Mouse   652 ISE--DKNPDYRK 662
            |:|  .|||::.:
  Fly   641 INEVIKKNPEFSR 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jup	NP_034723.1	ARM 6	342..381		15/43 (35%)
		armadillo repeat	345..380	CDD:293788	14/39 (36%)
		ARM 7	383..420		10/48 (21%)
		armadillo repeat	393..418	CDD:293788	6/33 (18%)
		ARM 8	423..464		12/44 (27%)
		armadillo repeat	426..464	CDD:293788	12/41 (29%)
		ARM 9	470..510		14/51 (27%)
		armadillo repeat	470..508	CDD:293788	12/49 (24%)
		ARM 10	512..551		7/40 (18%)
		armadillo repeat	515..572	CDD:293788	13/58 (22%)
		Interaction with DSC1. /evidence=ECO:0000250	574..661		16/88 (18%)
		armadillo repeat	577..611	CDD:293788	4/33 (12%)
		armadillo repeat	618..652	CDD:293788	6/33 (18%)
		Adaptin_N	<120..>289	CDD:366724	13/65 (20%)
		Interaction with DSC1 and DSG1. /evidence=ECO:0000250	132..297		15/73 (21%)
		armadillo repeat	144..169	CDD:293788
		armadillo repeat	186..212	CDD:293788
		armadillo repeat	221..253	CDD:293788	5/29 (17%)
		ARM	221..253	CDD:214547	5/29 (17%)
		armadillo repeat	261..297	CDD:293788	9/35 (26%)
		ARM 5	298..341		2/42 (5%)
		armadillo repeat	305..338	CDD:293788	0/32 (0%)
		PLN03200	<328..>658	CDD:215629	87/422 (21%)
		ARM	341..381	CDD:214547	15/44 (34%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	33/154 (21%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	9/35 (26%)
		armadillo repeat	304..339	CDD:293788	14/35 (40%)
		ARM	307..442	CDD:237987	35/135 (26%)
		armadillo repeat	347..392	CDD:293788	9/44 (20%)
		armadillo repeat	515..556	CDD:293788	10/40 (25%)
		ARM	516..643	CDD:237987	38/186 (20%)
		armadillo repeat	562..596	CDD:293788	12/56 (21%)
		armadillo repeat	601..641	CDD:293788	11/76 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940