Protein Alignment Ush1g and Sans

DIOPT Version :10

• Sequence 1: NP_789817.1
• Gene: Ush1g / 16470
• MGIID: 2450757
• Length: 461
• Species: Mus musculus
• Sequence 2: NP_610829.1
• Gene: Sans / 36427
• FlyBaseID: FBgn0033785
• Length: 516
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 181/549 - (32%)
• Similarity: 271/549 - (49%)
• Gaps: 124/549 - (22%)

Mouse     2 NDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGN 66
            :|::|:||:||.|::|..||||:.||.|.|.|||.:|||:.|.|::|||:..|||||||||.:||
  Fly     3 SDRFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGN 67

Mouse    67 TPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKL 131
            |.||||::.|||||:.|||.||.||:.||.|.|:..|:||:.|..|.:||||.......:...|.
  Fly    68 TALHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKK 132

Mouse   132 VGKLKDKAFREAERRIRECAKMQRKHHERMERRYRRELAERSD--TLSFSSLTSSTLSRRLQHMT 194
            ...||:.|.:..|:|:||..|.|.:..:|.:..|       ||  ..|.||.|.:.||      |
  Fly   133 SKALKELAEKNCEKRVREYMKRQNQQQQRQDPEY-------SDLSAPSGSSKTGNMLS------T 184

Mouse   195 LGSQLPYSQATLHGT--------------------------AKGKAKIQKK-LERRKQGG----- 227
            |..::..||..|:.|                          |.....:||: .:.:||..
  Fly   185 LKQKIWSSQGNLNKTPRDTPPPTKFSDLVGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPH 249

Mouse   228 -------EGTFKVSE---DGRKSVRSLSGLQLGSDVMFVRQGTYANPKE--WGRAPLRDMF---- 276
                   :|.|||.|   ||::::.||:|||..|:|::|  ||:::.::  ..|..:.|:|
  Fly   250 SKISSDTDGGFKVREVEPDGKRTITSLTGLQRDSEVLYV--GTFSSNEDSVGKRGKISDVFECME 312

Mouse   277 -----LSDEDSVSRATLAAEPAHSEVSTDSGHD-------------SLFTRPG-LGTMVFRRNYV 322
                 .||..|...:|||...:..::..|....             .||.||. ||::.|||:..
  Fly   313 ADELDHSDNRSGYSSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVT 377

Mouse   323 --------------SSGLHGLG------REDGGLDGAGTPRGRLHSSPSLDDDSLGSANSLQDRS 367
                          :|.:...|      |..||       :|||:.:.|.|.||.|..:.:
  Fly   378 AALSQLQLHTDTSSTSTMRNAGSNPPKTRNGGG-------KGRLYLNLSDDTDSEGGGHDI---- 431

Mouse   368 CGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFASLLRHEKIDLEALMLCSDLDLRSISVP 432
                  :.:.|   |:|.:...|.|:.|||...:|::..:.:.::||||.|||.::.||:|:.:|
  Fly   432 ------YSDDD---DDDRDAGGSALQRFLAVWALEEYLPVFQKQEIDLETLMLLTESDLKSLGLP 487

Mouse   433 LGPRKKILGAVRRRRQALERPLALEDTEL 461
            |||.:|:..|::.||.||..|..|.|:.|
  Fly   488 LGPFRKLTFAIQERRNALANPGPLVDSRL 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ush1g	NP_789817.1	ANKYR	<6..>117	CDD:440430	64/110 (58%)
		ANK repeat	31..62	CDD:293786	19/30 (63%)
		ANK 1	31..60		17/28 (61%)
		ANK repeat	64..95	CDD:293786	19/30 (63%)
		ANK 2	64..93		19/28 (68%)
		ANK 3	97..126		11/28 (39%)
		CEN_USH1G	296..388	CDD:409642	26/125 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..368		12/44 (27%)
		SAM_USH1G	388..453	CDD:188985	26/64 (41%)
Sans	NP_610829.1	ANKYR	<6..>118	CDD:440430	64/111 (58%)
		ANK repeat	35..63	CDD:293786	17/27 (63%)
		ANK repeat	65..96	CDD:293786	19/30 (63%)
		SAM_USH1G_HARP	443..508	CDD:188916	26/64 (41%)