DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jak3 and Src42A

DIOPT Version :9

Sequence 1:	NP_001177759.1	Gene:	Jak3 / 16453	MGIID:	99928	Length:	1100	Species:	Mus musculus
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	342	Identity:	118/342 - (34%)
Similarity:	168/342 - (49%)	Gaps:	44/342 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse   762 RRPSFRAI-------LRDLNGLITSDYELLSDPTPGIPSPRDELCGGAQLYACQDPAIFEERHLK 819
            ||.:||.:       .:|.:||..:    |..|...|..|..|    ...:..:|....:...||
  Fly  1273 RRTTFRTLQELVEHYSKDSDGLCVN----LCKPCVQIEKPVTE----GLSHRTRDQWEIDRTSLK 1329

Mouse   820 YISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRDFQREIQILKAL-HSDFIVKYR 883
            ::..||.|.||.|    ::.|.:||.| ||:|.|: ||....:||..|.||:|.| |:..|..|.
  Fly  1330 FVRKLGSGQFGDV----WEGLWNNTTP-VAIKTLK-SGTMDPKDFLAEAQIMKKLRHTKLIQLYA 1388

Mouse   884 GVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR---LHTDRLLLFAWQICKGMEYLGARRCVHRD 945
            ..:.   .:.:.::.|.:..|.|.::||....:   |....|:..|.||..||.||.::..:|||
  Fly  1389 VCTV---EEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRD 1450

Mouse   946 LAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFG 1010
            |||||:||.....|||||||||:|:.  :|.|..|...:.||.|.|||:.:.:.||.:|||||||
  Fly  1451 LAARNVLVGDGNIVKIADFGLARLIK--EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFG 1513

Mouse  1011 VVLYELFTYCDKSCSPSAEFLSMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWA 1075
            ::|.||.||      ....:..|...|        :|..:..|.|:|.||.|...:.|:|..||.
  Fly  1514 ILLTELVTY------GRIPYPGMTNAE--------VLTQVEHGYRMPQPPNCEPRLYEIMLECWH 1564

Mouse  1076 PSPHDRPAFGTLSPQLD 1092
            ..|..||.|.||..:|:
  Fly  1565 KDPMRRPTFETLQWKLE 1581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jak3	NP_001177759.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..223
		B41	41..246	CDD:214604
		FERM_C_JAK3	250..359	CDD:275413
		SH2	359..455	CDD:301589
		PKc_like	517..774	CDD:304357	5/18 (28%)
		Pkinase_Tyr	517..773	CDD:285015	4/17 (24%)
		PKc_like	813..1095	CDD:304357	105/284 (37%)
		Pkinase_Tyr	818..1091	CDD:285015	104/276 (38%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	8/31 (26%)
		PTKc_Frk_like	1319..1587	CDD:270653	106/288 (37%)
		Pkinase_Tyr	1328..1580	CDD:285015	104/276 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910