back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jak2 and Src42A

DIOPT Version :9

Sequence 1:	NP_001041642.1	Gene:	Jak2 / 16452	MGIID:	96629	Length:	1132	Species:	Mus musculus
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	1178	Identity:	252/1178 - (21%)
Similarity:	409/1178 - (34%)	Gaps:	408/1178 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse   238 QQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKESAR------GPSGEEIFATIIITGNGGI 296
            :.:.:|...:||.:..|    |..::.|.....|..:|..      .|:.:...|:..:.....|
  Fly   531 RNYKECLTQSRNRRKSY----EEFKAMFIEPPAEASKSVTVPPPVVAPADDATTASSTVIPLSSI 591

Mouse   297 QWSRGKHKESETLTEQDVQLYCDFPDIIDVSIKQANQECSNESRIVTVHK---------QDGKVL 352
                   .|.|.:..:.|               :...:|:||....|...         :.|...
  Fly   592 -------SEQENIGSRGV---------------RGKPDCANEFTASTDEMDTGDGNSDGEKGAAA 634

Mouse   353 EIEL-------------SSLKEAL----SFVS-LIDGYY--RLTADAH---------HYLCKEVA 388
            |::|             ||..||:    .|:| ::|..:  :..|.||         ..|..|:.
  Fly   635 EVDLTTETTATAKTLVSSSTTEAMRKNSDFLSQILDHQFAAKERAKAHKRRTSYEEFKRLVNEIE 699

Mouse   389 P---PAVLENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK 450
            |   |.....:.:......:...|.:.|.|..|..       ..|.|..|||.   .|.:..|.|
  Fly   700 PLECPNTQPTVSAAVTPTTATAAAAASLIKRQNSR-------QRKSFASYFLP---HRHSTKEQK 754

Mouse   451 HCLITKNEN-----------------GEYNLSGTKRNFSNLKDLLNCYQMETVRSDSIIFQFTKC 498
                |:.||                 |:..|     :.||..|:.:.|.....
  Fly   755 ----TEKENCSRDPIKPSQEQQLAVCGKLPL-----HRSNTSDISSSYYRRNF------------ 798

Mouse   499 CPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQM------------VFHKIRNE-------- 543
               |..||   ||:.|  |.|:     :||.|::.|.            :.|:..::
  Fly   799 ---KIYDK---LVYGT--IYDI-----IQRKNDIYQKYDKYMTYGTIYEILHRKTSQSSDPWQRK 850

Mouse   544 -------------DLIFN---------ESLGQ--------------GTFTKIFKGVRREVGDY-- 570
                         |:|::         .:||.              ||...|.:||:.:.|..
  Fly   851 SLSSILEGGRSSGDIIYDIGQRRERDKRTLGSSSSATVSTINPHKYGTIYDILQGVKIDAGHVKN 915

Mouse   571 --GQLHK------------------TEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGV 615
              .|..|                  ..|.:...|::.::..|.....::..:::.....:|:|.
  Fly   916 KPDQKSKPTKPPLAKPTRFVVSQVVEPVQIPPTDQSGKSVQEQGAPKSNKPNKMRRLSNILSYS- 979

Mouse   616 CVCGEENILVQEFVKFGSLDTYLKKN--KNSI---NILWKL--------------GVAKQLAWAM 661
            ...||:.   ||..  |..:|..|:.  |..|   |:|..|              |:.|:.:...
  Fly   980 RNSGEDQ---QETT--GKEETKPKRTQAKRRIGVTNLLLPLDSEELYTRIIAQQRGLDKEHSQEP 1039

Mouse   662 HFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLP----------KDILQERI 716
               |||......:|.:|.|        |.:.....:|   :|:.:.|          :.:.|.|
  Fly  1040 ---EEKCASEEQMCTRNAL--------TKSSSLDAIS---LSVAISPASSPSPPRPRRSLKQHR- 1089

Mouse   717 PWVPPECIENPKNLNLATD--------------------KWSFGTTLWEIC--SGGDKPLSALDS 759
                  |::..:...||..                    :||..|.|...|  :..:.||:|::.
  Fly  1090 ------CLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPLTAIEK 1148

Mouse   760 QRKL--------------------------------------------------QFYEDK----- 769
            .|.|                                                  :|..:|
  Fly  1149 SRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFR 1213

Mouse   770 --------HQLPAPKWTELANLINNC----MDY-------------------EPDFRPAFRAVIR 803
                    .:|..|:....|.||.:.    .||                   |..|..|.|...|
  Fly  1214 KIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFR 1278

Mouse   804 DLNSL---FTPDYELLTENDMLPNMRIGALGFSG-AFEDRDPTQFEERHLKFLQQLGKGNFGSVE 864
            .|..|   ::.|.:.|..|...|.::|......| :...||..:.:...|||:::||.|.||.|
  Fly  1279 TLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDV- 1342

Mouse   865 MCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIM 929
               ::.|.:|| ..||:|.|:..|.:. :||..|.:|:|.|:|..:::...||  .....:.:|.
  Fly  1343 ---WEGLWNNT-TPVAIKTLKSGTMDP-KDFLAEAQIMKKLRHTKLIQLYAVC--TVEEPIYIIT 1400

Mouse   930 EYLPYGSLRDYLQ--KHKER-IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVK 991
            |.:.:|||.:|||  ..|.| :..:.|:...:||..||.||.::.|||||||.||:||.:.|.||
  Fly  1401 ELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVK 1465

Mouse   992 IGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKS 1056
            |.||||.:::.:|:  |:.:.....||.|.|||:...||||:.|||||||::|.||.||
  Fly  1466 IADFGLARLIKEDE--YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTY------ 1522

Mouse  1057 PPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSL 1121
                     |......|....::..::...|:|:|..|...:|.||.|||:.:..:||:|..|..
  Fly  1523 ---------GRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQW 1578

Mouse  1122 RVDQIRDS 1129
            :::....|
  Fly  1579 KLEDFYTS 1586

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.