DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jag2 and Dl

DIOPT Version :9

Sequence 1:	XP_011242300.1	Gene:	Jag2 / 16450	MGIID:	1098270	Length:	1254	Species:	Mus musculus
Sequence 2:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster

Alignment Length:	875	Identity:	276/875 - (31%)
Similarity:	363/875 - (41%)	Gaps:	221/875 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 RLLLLLVLC---VQATRPMGYFELQLSALRNVNGELLSGACCDG--DGRTTRAGGCGRDECDTYV 71
            :.||...:|   :......|.|||:|....|.:|....|.||.|  ||.|.:..|    .|.|..
  Fly     5 KCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLG----SCKTRF 65

Mouse    72 RVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRTGGHQDPGLVVIPFQF 136
            |||||.|||.:..|..|:||...||:||.||..|..|        .|.:..|..:|  :..||.|
  Fly    66 RVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDA--------QRFQNKGFTNP--IQFPFSF 120

Mouse   137 AWPRSFTLIVEAWDWDNDTTPDANSAAPKEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQI 201
            :||.:|:||||||   :||....|:...|  |||:|:....::.....||:.........||...
  Fly   121 SWPGTFSLIVEAW---HDTNNSGNARTNK--LLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDF 180

Mouse   202 RVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVP 266
            ||.||.|||.:.|.||||||:|.|||.||.:.|...|:.||.|..|....|.:||.  ||.|..|
  Fly   181 RVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKP 243

Mouse   267 GECRCSYGWQGKFCDECVPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCI 331
            .:|.|..||:|..|:|||..|.|:||:|.:||.|.|...||||.|::|||||.:|.||.|||||.
  Fly   244 NQCVCQLGWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCF 308

Mouse   332 NAEPDQYLCACPDGYLGKNCERAEHACAS--NPCANGGSCHEVP---SGFECHCPSGWNGPTCAL 391
            |.....|.|.|..||.|.:||...::|.:  |||.|||:|.:.|   :|::|||.:||:|..|..
  Fly   309 NTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEE 373

Mouse   392 DIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNL---IG--- 450
            .:..|:..||..|                                       .|:|:   :|
  Fly   374 KVLTCSDKPCHQG---------------------------------------ICRNVRPGLGSKG 399

Mouse   451 -GYYCDCLPGWKGINCQININDCH-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYDKCASSP 513
             ||.|:|..|:.|.||.:.:::|. ..|.:||:|:.  :| :|:||.||.|..||...|.|....
  Fly   400 QGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQP--SG-KCICPAGFSGTRCETNIDDCLGHQ 461

Mouse   514 CRRGGICEDLVDGFRCHCPRGLSGLHCEVDMDLCEPSPCLNGARCYNLEGDYYCACPEDFGGKNC 578
            |..||.|.|:|:.:||.|..|..|.||...:|||...||.||..|.||..||.|.|...|.||:|
  Fly   462 CENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDC 526

Mouse   579 SVPRDTCPGGACRVIDGCGFEAGSRARGVAPSGICGPHGHCVSLPGGNFSCICDSGFTGTYCHEN 643
            ||                                                              :
  Fly   527 SV--------------------------------------------------------------D 529

Mouse   644 IDDCMGQPCRNGGTCIDEVDSFRCFCPSGWEGELCDINPNDCLPDPCHSRG-----RCYDLVN-- 701
            ||:|...||.|||||::.|:||.|.|.:|:.|:.||....|.:....|..|     |...|.|
  Fly   530 IDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQ 594

Mouse   702 --------------DFYCAC---------------DDGWKGK--------TCHSR---------E 720
                          ....||               ||....|        |.|..         .
  Fly   595 VVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVALAS 659

Mouse   721 FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNS--SCVPNPCVNGGTCVGSGDSF-SC 782
            ......|.||.|..:|.|:.              .|.||:  ..|.|.|.:......:..:. .|
  Fly   660 ASLGGKTGSNSGLTFDGGNP--------------NIIKNTWDKSVNNICASAAAAAAAAAAADEC 710

Mouse   783 ICRDGWEGRTCTHNTNDCNPLPCYNGGICV 812
            :...|:......:|.        .|...||
  Fly   711 LMYGGYVASVADNNN--------ANSDFCV 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jag2	XP_011242300.1	MNNL	28..103	CDD:369454	34/76 (45%)
		DSL	185..247	CDD:366627	29/61 (48%)
		EGF_CA	314..352	CDD:238011	20/37 (54%)
		EGF	358..388	CDD:333761	16/34 (47%)
		EGF_CA	392..428	CDD:238011	4/35 (11%)
		EGF_CA	430..466	CDD:238011	10/42 (24%)
		EGF_CA	468..503	CDD:238011	12/35 (34%)
		EGF_CA	507..541	CDD:238011	14/33 (42%)
		EGF_CA	543..578	CDD:238011	17/34 (50%)
		EGF_CA	643..678	CDD:238011	17/34 (50%)
		EGF_CA	683..716	CDD:238011	11/76 (14%)
		EGF	723..753	CDD:333761	6/29 (21%)
		EGF_CA	764..794	CDD:238011	4/30 (13%)
		EGF_CA	<804..831	CDD:238011	3/9 (33%)
		EGF_CA	834..870	CDD:238011
		VWC_out	879..950	CDD:214565
Dl	NP_001247193.1	MNNL	23..96	CDD:284966	33/76 (43%)
		DSL	164..226	CDD:279722	29/61 (48%)
		EGF_CA	291..329	CDD:238011	20/37 (54%)
		EGF_CA	337..372	CDD:238011	15/34 (44%)
		EGF_CA	453..488	CDD:238011	13/34 (38%)
		EGF_CA	492..526	CDD:238011	17/33 (52%)
		EGF_CA	529..564	CDD:238011	17/34 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920