DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Jag1 and Dl

DIOPT Version :9

Sequence 1:NP_038850.1 Gene:Jag1 / 16449 MGIID:1095416 Length:1218 Species:Mus musculus
Sequence 2:NP_001247193.1 Gene:Dl / 42313 FlyBaseID:FBgn0000463 Length:833 Species:Drosophila melanogaster


Alignment Length:585 Identity:238/585 - (40%)
Similarity:321/585 - (54%) Gaps:44/585 - (7%)


- Green bases have known domain annotations that are detailed below.


Mouse    22 CALRAKVC-------GASGQFELEILSMQNVNGELQNGNCCGGVRNPGDRKCTRDECDTYFKVCL 79
            |.|.|.:|       .:||.|||.:....|.:|....|.||.|..:....||. ..|.|.|:|||
  Fly     6 CLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCL-GSCKTRFRVCL 69

Mouse    80 KEYQSRVTAGGPCSFGSGSTPVIGGNTFNL-KASRGNDR---NRIVLPFSFAWPRSYTLLVEAWD 140
            |.||:.:.....|::|...||::|.|:.|| .|.|..::   |.|..||||:||.:::|:||||.
  Fly    70 KHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWH 134

Mouse   141 SSNDTIQPDS---IIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRP 202
            .:|::....:   :|::.....::..|.:|:|.|..:.....||..|||||.:|||.||.|||||
  Fly   135 DTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRP 199

Mouse   203 RDDFFGHYACDQNGNKTCMEGWMGPDCNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIP 267
            |||.|||..|.:.|...|:.||.|..|:...|.:||  :||.|..|..|.||.||:|..|::|:.
  Fly   200 RDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGC--EHGHCDKPNQCVCQLGWKGALCNECVL 262

Mouse   268 HPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPN 332
            .|.|:|||||:||.|:|...|||..|::|||||..|:||.|.|||.|||...|.|.|..||||.:
  Fly   263 EPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDD 327

Mouse   333 CEIAEHACLSD--PCHNRGSC---KETSSGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL 392
            ||...::|.:|  ||.|.|:|   ..|.:|::|.|:.||:|..|...:..||...| |.|.|:::
  Fly   328 CENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQGICRNV 391

Mouse   393 -------VNGFKCVCPPQWTGKTCQLDANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCDIN 450
                   ..|::|.||..::|..|.|..:.|...||:|..||:   .|..|.|..|:.|..|:.|
  Fly   392 RPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQ---PSGKCICPAGFSGTRCETN 453

Mouse   451 INDCLG-QCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCP 514
            |:|||| ||:|..:|.|:||.|||.|.||:.|.||...:|.|...||.|||.|.|..|.:||.|.
  Fly   454 IDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCR 518

Mouse   515 TGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTTCEVIDSCT 579
            .||:|..|.:|||.|...||.||..|.||.:.:.|.|...:.||.|..          |..||.|
  Fly   519 AGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDE----------ESYDSVT 573

Mouse   580  579
              Fly   574  573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Jag1NP_038850.1 MNNL 32..106 CDD:284966 27/73 (37%)
DSL 167..229 CDD:279722 32/61 (52%)
Important for interaction with NOTCH1. /evidence=ECO:0000250 199..207 7/7 (100%)
EGF_CA 296..334 CDD:238011 22/37 (59%)
EGF 340..370 CDD:278437 14/34 (41%)
EGF_CA 374..410 CDD:238011 11/42 (26%)
EGF_CA 412..447 CDD:238011 11/34 (32%)
EGF_CA 450..485 CDD:238011 21/35 (60%)
EGF_CA 487..523 CDD:238011 16/35 (46%)
EGF_CA 525..560 CDD:238011 15/34 (44%)
EGF_CA 629..665 CDD:238011
EGF_CA 667..702 CDD:238011
EGF_CA <714..740 CDD:238011
EGF 748..777 CDD:278437
EGF_CA 782..817 CDD:238011
EGF_CA 820..855 CDD:238011
VWC_out 863..930 CDD:214565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1218
DlNP_001247193.1 MNNL 23..96 CDD:284966 27/73 (37%)
DSL 164..226 CDD:279722 32/61 (52%)
EGF_CA 291..329 CDD:238011 22/37 (59%)
EGF_CA 337..372 CDD:238011 13/34 (38%)
EGF_CA 453..488 CDD:238011 20/34 (59%)
EGF_CA 492..526 CDD:238011 16/33 (48%)
EGF_CA 529..564 CDD:238011 15/34 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834953
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D197806at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.850

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