Protein Alignment DDB2 and snrp-40.1

DIOPT Version :9

• Sequence 1: NP_000098.1
• Gene: DDB2 / 1643
• HGNCID: 2718
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_509886.1
• Gene: snrp-40.1 / 181319
• WormBaseID: WBGene00008586
• Length: 331
• Species: Caenorhabditis elegans
• Alignment Length: 297
• Identity: 67/297 - (22%)
• Similarity: 121/297 - (40%)
• Gaps: 53/297 - (17%)

Human   124 PSTVAVGSKGGD--IMLWN-FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 185
            |....:.:.|.|  |..|| :|..:..:.||  |..|::..|||. .:::...:...:.:.|:.|
 Worm    48 PDGTCLATSGYDQKIFFWNVYGECENFSTIK--GHSGAVMDLKFT-TDSSSLVSCGTDKSVRVWD 109

Human   186 FK-GNILRVFAS-SDTINIWFCSLDVSASSR---MVVTGDNVGNVILLNMDGKELWNLRMHKKKV 245
            .: |...|.|.: :|.:|.      |..|.|   :|.:..:.|...:.:|..||......::.:.
 Worm   110 METGTCARRFRTHTDFVNA------VHPSRRGVTLVASASDDGTCRVHDMRTKEPVKTYTNRYQQ 168

Human   246 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQK 309
            |.|..|...|..: :..:|..:|:||:|    :....|:|. ||..:.....||.|..:::....
 Worm   169 TAVTFNDSSDQVI-SGGIDNVLKVWDMR----RDEITYTLTGHRDTITGISLSPSGKFIISNSMD 228

Human   310 SEIRVYSASQWDC--------PLGLIP-HPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT 365
            ..:|     |||.        .:|:.. |.|...::|  :|.:|.|....|..|...
 Worm   229 CTVR-----QWDIRPFVPGQRSVGVFAGHNHNFEKNL--LKCSWSPCERFITAGSSD-------- 278

Human   366 PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNP 402
                |.:.|::..|.|::.:|  |...|..:..:|:|
 Worm   279 ----RFLYVWETLSKKIVYKL--PGHMGSVNCTDFHP 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDB2	NP_000098.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Required for interaction with DDB1	68..79
		Required for interaction with DDB1	87..98
		WD40	115..419	CDD:330360	67/297 (23%)
		WD40 repeat	115..154	CDD:293791	9/32 (28%)
		WD 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:19109893	116..151		7/29 (24%)
		WD 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:19109893	159..194		7/35 (20%)
		WD40 repeat	160..195	CDD:293791	7/35 (20%)
		WD40 repeat	200..239	CDD:293791	9/41 (22%)
		WD 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:19109893	203..238		8/37 (22%)
		WD 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:19109893	244..287		11/43 (26%)
		WD40 repeat	246..284	CDD:293791	9/37 (24%)
		DWD box	256..274		4/17 (24%)
		WD 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:19109893	290..329		8/47 (17%)
		WD40 repeat	291..328	CDD:293791	8/44 (18%)
		Photolesion recognition	334..336		0/1 (0%)
		WD 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:19109893	343..386		8/42 (19%)
		WD 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:19109893	396..420		2/7 (29%)
snrp-40.1	NP_509886.1	WD40	33..323	CDD:238121	67/297 (23%)
		WD40 repeat	42..79	CDD:293791	9/32 (28%)
		WD40 repeat	84..120	CDD:293791	7/36 (19%)
		WD40 repeat	127..161	CDD:293791	9/39 (23%)
		WD40 repeat	168..204	CDD:293791	10/40 (25%)
		WD40 repeat	210..250	CDD:293791	8/44 (18%)
		WD40 repeat	260..284	CDD:293791	7/37 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910