DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDB2 and Ddb2

DIOPT Version :9

Sequence 1:	NP_000098.1	Gene:	DDB2 / 1643	HGNCID:	2718	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_001258275.1	Gene:	Ddb2 / 100362121	RGDID:	1310164	Length:	432	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	333/422 - (78%)
Similarity:	371/422 - (87%)	Gaps:	0/422 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPP 65
            |||||.|||||:.::.:..::|..|||.|||||||||..:|...||:|:|.||...|:..||.|.
  Rat     1 MAPKKCPETQKSPDVAVLLKSKSRRSPQELEPEAKKLFVQGPVSSRKCESCCLLAELSSLQIPPR 65

Human    66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVG 130
            ..||||.|:|.|||:|:|||:|||||:||||:|.|||:.|||||||||.||||||||||||:|||
  Rat    66 SSSIVRDLYQQKLGKATWPSLQQGLQKSFLHSLASYRVFQKAAPFDRRTTSLAWHPTHPSTLAVG 130

Human   131 SKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFA 195
            |||||||:|||||||||.|:|||||||||||||||.||||||:|||||||||||||||||||::.
  Rat   131 SKGGDIMIWNFGIKDKPIFLKGIGAGGSITGLKFNHLNTNQFFASSMEGTTRLQDFKGNILRIYT 195

Human   196 SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLAT 260
            ||::..:|||||||||.||:||||||:|:|||.|.|||||||||||||||.||||||||||.|||
  Rat   196 SSNSCKVWFCSLDVSAKSRVVVTGDNMGHVILTNTDGKELWNLRMHKKKVAHVALNPCCDWLLAT 260

Human   261 ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLG 325
            ||:|||||||||||::||.|||:|||||||||:|||||||||||||||.:|||||||||||.||.
  Rat   261 ASIDQTVKIWDLRQIKGKDSFLFSLPHRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLS 325

Human   326 LIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPE 390
            ||.||||||||||||||.||.|:||||||||||||.|||.||||||||||||:|||||||||||.
  Rat   326 LISHPHRHFQHLTPIKATWHSRHNLIVVGRYPDPNLKSCVPYELRTIDVFDGSSGKMMCQLYDPG 390

Human   391 SSGISSLNEFNPMGDTLASAMGYHILIWSQEE 422
            .|||:||||||||||||||.|||||||||.||
  Rat   391 YSGITSLNEFNPMGDTLASTMGYHILIWSPEE 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDB2	NP_000098.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		14/28 (50%)
		Required for interaction with DDB1	68..79		7/10 (70%)
		Required for interaction with DDB1	87..98		9/10 (90%)
		WD40	115..419	CDD:330360	260/303 (86%)
		WD40 repeat	115..154	CDD:293791	34/38 (89%)
		WD 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	116..151		31/34 (91%)
		WD 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	159..194		32/34 (94%)
		WD40 repeat	160..195	CDD:293791	31/34 (91%)
		WD40 repeat	200..239	CDD:293791	29/38 (76%)
		WD 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	203..238		28/34 (82%)
		WD 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	244..287		35/42 (83%)
		WD40 repeat	246..284	CDD:293791	31/37 (84%)
		DWD box	256..274		15/17 (88%)
		WD 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	290..329		33/38 (87%)
		WD40 repeat	291..328	CDD:293791	31/36 (86%)
		Photolesion recognition	334..336		1/1 (100%)
		WD 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	343..386		36/42 (86%)
		WD 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	396..420		22/23 (96%)
Ddb2	NP_001258275.1	WD40	65..>431	CDD:225201	299/358 (84%)
		WD40	115..419	CDD:295369	260/303 (86%)
		WD40 repeat	115..154	CDD:293791	34/38 (89%)
		WD40 repeat	160..199	CDD:293791	33/38 (87%)
		WD40 repeat	204..239	CDD:293791	28/34 (82%)
		WD40 repeat	246..284	CDD:293791	31/37 (84%)
		WD40 repeat	291..328	CDD:293791	31/36 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83683554
Domainoid	1	1.000	346	1.000	Domainoid score	I13026
eggNOG	1	0.900	-	-		E1_KOG4328
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83
Inparanoid	1	1.050	705	1.000	Inparanoid score	I8742
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46827
OrthoDB	1	1.010	-	-		D137810at32523
OrthoFinder	1	1.000	-	-		FOG0009487
OrthoInspector	1	1.000	-	-		oto143766
orthoMCL	1	0.900	-	-		OOG6_109982
Panther	1	1.100	-	-	LDO	PTHR15169
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270