DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDB2 and ddb2

DIOPT Version :9

Sequence 1:	NP_000098.1	Gene:	DDB2 / 1643	HGNCID:	2718	Length:	427	Species:	Homo sapiens
Sequence 2:	XP_005159091.1	Gene:	ddb2 / 100004133	ZFINID:	ZDB-GENE-050419-169	Length:	503	Species:	Danio rerio

Alignment Length:	432	Identity:	195/432 - (45%)
Similarity:	283/432 - (65%)	Gaps:	22/432 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     6 RPETQKTSEIVLRPRNKRSRSPLEL-EPEAKKLCAKGSGPSRRCDSDCLWVGL--AGPQILPPCR 67
            |.:|...:....:..|.:.|...|. :|..|||.||....|::.:...:...:  .|.|......
Zfish     5 RAQTDSAASKQTKTVNSKKRPNEETPQPSTKKLKAKQQHKSKQKEETYIQASVKWTGGQKKVGQT 69

Human    68 SIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSK 132
            ||:..:::..||::....::|.||:.|:.:|.||::.:.|:|||||.|||.||||||:|||||||
Zfish    70 SILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSK 134

Human   133 GGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASS 197
            ||||:||::.:.:|.:||:|.|||..|.|:||.|.::::.:.:|.:||..:|.|:|...::.:.:
Zfish   135 GGDIILWDYDVLNKTSFIQGKGAGDFIGGMKFCPRDSSKVFVASGDGTVSVQSFEGLQSQILSRT 199

Human   198 -------DTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCD 255
                   ..:..|:|.:|||.|.:|:.|||:.|.::||.:||.|::..::||.||||...||.||
Zfish   200 PDCGHDHHDLCYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCD 264

Human   256 WFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP-DGARLLTTDQKSEIRVYSASQ 319
            |.:||:|||.|||:||||.::.|.|::..:||..|||||.|:| |..:||||||::||||||:..
Zfish   265 WLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYD 329

Human   320 WDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDP----NFKSCTPYELRTIDVFDGNSG 380
            |..|..:|.||||.|||||||||.|||.|:|||.|||||.    |.|       ||||::|.|||
Zfish   330 WSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDK-------RTIDIYDANSG 387

Human   381 KMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEE 422
            .::.||.||.::||.|||:|:|.||.|||.||::||||::|:
Zfish   388 GLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFNILIWNRED 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDB2	NP_000098.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		4/23 (17%)
		Required for interaction with DDB1	68..79		2/10 (20%)
		Required for interaction with DDB1	87..98		4/10 (40%)
		WD40	115..419	CDD:330360	162/315 (51%)
		WD40 repeat	115..154	CDD:293791	26/38 (68%)
		WD 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	116..151		23/34 (68%)
		WD 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	159..194		11/34 (32%)
		WD40 repeat	160..195	CDD:293791	10/34 (29%)
		WD40 repeat	200..239	CDD:293791	16/38 (42%)
		WD 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	203..238		16/34 (47%)
		WD 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	244..287		23/42 (55%)
		WD40 repeat	246..284	CDD:293791	21/37 (57%)
		DWD box	256..274		12/17 (71%)
		WD 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	290..329		23/39 (59%)
		WD40 repeat	291..328	CDD:293791	21/37 (57%)
		Photolesion recognition	334..336		1/1 (100%)
		WD 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	343..386		22/46 (48%)
		WD 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:19109893	396..420		16/23 (70%)
ddb2	XP_005159091.1	WD40	64..>437	CDD:225201	181/373 (49%)
		WD40	105..426	CDD:295369	168/327 (51%)
		WD40 repeat	116..156	CDD:293791	26/39 (67%)
		WD40 repeat	162..203	CDD:293791	10/40 (25%)
		WD40 repeat	213..246	CDD:293791	15/32 (47%)
		WD40 repeat	255..293	CDD:293791	21/37 (57%)
		WD40 repeat	300..338	CDD:293791	21/37 (57%)
		WD40 repeat	346..390	CDD:293791	29/50 (58%)
		WD40 repeat	401..425	CDD:293791	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330339
Domainoid	1	1.000	178	1.000	Domainoid score	I14724
eggNOG	1	0.900	-	-		E1_KOG4328
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83
Inparanoid	1	1.050	419	1.000	Inparanoid score	I7634
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46827
OrthoDB	1	1.010	-	-		D196366at7742
OrthoFinder	1	1.000	-	-		FOG0009487
OrthoInspector	1	1.000	-	-		oto47109
orthoMCL	1	0.900	-	-		OOG6_109982
Panther	1	1.100	-	-	LDO	PTHR15169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6012
SonicParanoid	1	1.000	-	-		X6171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300