DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgb7 and Itgbn

DIOPT Version :9

Sequence 1:	NP_038594.2	Gene:	Itgb7 / 16421	MGIID:	96616	Length:	806	Species:	Mus musculus
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	257/816 - (31%)
Similarity:	386/816 - (47%)	Gaps:	105/816 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    29 GEAAEW------------EDPDLSLQGSCQPVPSCQKCILSHPSCAWCKQLNFTASGEAEARRCA 81
            |.|..|            .|.| |:...|:...||::|:.:|..||||....:..     ..||.
  Fly     6 GRAFLWIYLVFLIAEISHSDAD-SIDDQCRHADSCERCLSAHLECAWCTDKEYQV-----GYRCL 64

Mouse    82 RREELLARGCPAQELEEPRGRQEVLQDKPLSQGDRGEGATQLAPQRIRVTLRPGEPQKFRVRFLR 146
            .|.:||...|...::.|.:...:|||||||...:..:.|.|:.|||..:.|..|..|:.::.:..
  Fly    65 SRRQLLNYNCSETDIYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRT 129

Mouse   147 AAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSK 211
            |...|:|||.||||:::|:||.:.:.:||..|...|:.:|.:.|:|||||.||..||.:  :|..
  Fly   130 ARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQH 192

Mouse   212 LHHPCPSRLERCQPPFSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIG 276
            ..:||.:....|:|.:.:.|.||||.|..||...|....::||||:.|||.||::|..:|.::||
  Fly   193 RENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIG 257

Mouse   277 WRNVSR-LLVFTSDDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAA 340
            |:..:| :::..:|...|.||||.|.||...:|.:|||:..|.||.|..:||||:.::.:.|...
  Fly   258 WKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRR 322

Mouse   341 NIQPIFAVTGATLPVYQELRQLIPK-SAVGELSEDSSNVVQLIMDAYDSL-SSTVTLEHSPLPPG 403
            .|..|||||...:..|.||..|:.: |.|..||.||||:::||..:|:|| ..|...::|  |..
  Fly   323 KINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADNS--PDF 385

Mouse   404 VSISFESHCKG--PEKTEGEAGDRGQCNDVRVNQTVDFW--VTLQATHCLPE----AHVLRLWAL 460
            :.:::.:.|.|  |...:     |..||:|.:.:.:||:  |||:.   .|:    .|.:|:...
  Fly   386 IDMAYYTDCGGQFPSLQK-----RNYCNNVTLGKQIDFYVDVTLKK---YPDNQVYTHKIRVEET 442

Mouse   461 GFSE--ELTVELHTVCDC-NCGDAQ-PHAPYCSDGQGDLQCGICSCAPGRLGQLCEC-SEAD--L 518
            ..||  :|.|||...|.| ...|.: ....:..|.:|.|.||:|.|..|..|..|.| ::|.  .
  Fly   443 SLSEFMDLDVELQRPCPCQETPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVT 507

Mouse   519 SSPDLESGCRAP---NGTGPL-CSGKGRCQCGRCSCSGQSSGRLCECDDA-SCERHEGILCGGFG 578
            |:..|...||.|   ..|..| ||..|.|.||.|.|....:|..|||.:. .|:..       ..
  Fly   508 SNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLCDPGYTGPFCECRECLDCDEK-------LA 565

Mouse   579 HCQCGVCHCHANHTGRACECSKSVDSCVSPEGGLCSGHGYCKCNRCQCLDGYYGALC------DQ 637
            .|.||.|.|....:|..|.|....|:||.|.|.:||..|.|:|..|||.:.|.|..|      |.
  Fly   566 DCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEPYLGKFCEIDPEKDN 630

Mouse   638 CLGCKSPCEQYRDCAEC---GAFGTGPLAANCSVVCADV--------NVTLTLAPNLDDGWCKER 691
            .|     |..|..|..|   ...|.| :..|.:.:|:.:        |....|.|..|.  |..|
  Fly   631 KL-----CLFYEPCVTCLIEQKQGMG-VCENLTEICSSLDRQETYPYNFVHELDPEQDQ--CLVR 687

Mouse   692 TI-------DNQLFFFLVEHAASGIVLRVRPQEKGVDHTRAIILGCTGGIVA----VGLGLVLAY 745
            .:       |:...:.:::|:....:       :.||......:...|.|.|    :||.::...
  Fly   688 LVNKHGIQCDSFFVYQVIDHSNFLTI-------QAVDCEPPDYVALVGYISAFTLLIGLLIIFII 745

Mouse   746 RLSVEIYDRREYRRFEKEQQQLNWKQDNNPLYKSAI 781
            ...:...|.|||.:||::|:  |..:..||:|:..:
  Fly   746 LWYIRAKDAREYAKFEEDQK--NSVRQENPIYRDPV 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgb7	NP_038594.2	INB	50..476	CDD:197563	156/438 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..123		9/24 (38%)
		Cysteine-rich tandem repeats	478..640		58/176 (33%)
		EGF_2	607..635	CDD:285248	12/27 (44%)
		Integrin_B_tail	645..716	CDD:285239	16/88 (18%)
		Integrin_b_cyt	749..790	CDD:285884	11/33 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..806
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	156/438 (36%)
		EGF_2	524..552	CDD:285248	11/27 (41%)
		Integrin_b_cyt	748..785	CDD:285884	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.780