DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgb6 and Itgbn

DIOPT Version :9

Sequence 1:	NP_001153036.1	Gene:	Itgb6 / 16420	MGIID:	96615	Length:	787	Species:	Mus musculus
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	257/815 - (31%)
Similarity:	399/815 - (48%)	Gaps:	101/815 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 DHVQGGCAWGGAESCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPANLLAKGC-QLPFIEN-PV 79
            |.:...|.  .|:||..||.....||||:.:.:.    .|.||.:...||...| :....|| ||
  Fly    27 DSIDDQCR--HADSCERCLSAHLECAWCTDKEYQ----VGYRCLSRRQLLNYNCSETDIYENQPV 85

Mouse    80 SRIEVLQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSAS 144
              ::|||:|||.  ..:.|...||:.||...|||..|..|.:::..|...:.|:|||.||||:.:
  Fly    86 --LDVLQDKPLK--DYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWT 146

Mouse   145 MDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFG 209
            |.||..|::|||::|::.:..||.|:|||||||.:||..|.:  .|:...|||::....|.||:|
  Fly   147 MRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI--LPQHRENPCAAERATCEPTYG 209

Mouse   210 FKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADS 274
            ::|.|.||||...|...|...||:.|:|..|||.||:||..||.::|||:..:..:::.|:|...
  Fly   210 YRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFM 274

Mouse   275 HFGMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYE 339
            |...|..||||:..||..|||:...||:.|...:||::.::..:|::..:.:|||||:|.|..|.
  Fly   275 HLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYW 339

Mouse   340 NYAKLIPGAT-VGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCNNGVLFPHQ 403
            ..:.|:...: |.:|..||.|||:||..:||.|....:. .....:.:::::...|  |..||..
  Fly   340 ELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYTDC--GGQFPSL 401

Mouse   404 KK---CSHMKVGDTASFNVTVSVS---NCEKRSRNLIIKPVGLGDTLEILVSAECDCDCQREIET 462
            :|   |:::.:|....|.|.|::.   :.:..:..:.::...|.:.:::.|..:..|.||   ||
  Fly   402 QKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMDLDVELQRPCPCQ---ET 463

Mouse   463 NSSKCHNG------NGSFQCGVCTCNPGHMGPHCECGEDMVSTDS-------CKE-----SPGHP 509
            ...:...|      .|...||:|.|:.|..|.:|.|..|..:..|       |::     |....
  Fly   464 PDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSEL 528

Mouse   510 SCSGRGDCYCGQCICHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDN-GDCDCGECVCRDGWTGEY 573
            .||..|||.||.|:|  .|  ...||:|:|.  .||.     |.:. .||.||:|||:.||:|..
  Fly   529 VCSNHGDCDCGTCLC--DP--GYTGPFCECR--ECLD-----CDEKLADCFCGQCVCKYGWSGSK 582

Mouse   574 CNCTTNRDSCTSEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDP-CNSKRSCIECYLSA 637
            |||..:.|:|....|.:||.||.|.|.:|.|..| ..|..||..|...:. |.....|:.|.:.
  Fly   583 CNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFYEPCVTCLIE- 645

Mouse   638 DGQAQ-----EECADKCKAIGAT-------ISEEDFSKDTSVSCSLQGENECLITFL----ITTD 686
              |.|     |...:.|.::...       :.|.|..:|           :||:..:    |..|
  Fly   646 --QKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQD-----------QCLVRLVNKHGIQCD 697

Mouse   687 N--EGKTIIHN----INEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFE 745
            :  ..:.|.|:    |...|| :||:...::..:|...||||::::.|....:...|.:|.||||
  Fly   698 SFFVYQVIDHSNFLTIQAVDC-EPPDYVALVGYISAFTLLIGLLIIFIILWYIRAKDAREYAKFE 761

Mouse   746 AERSKAKWQTGTNPLYRGSTSTF---KNVTYKHRE 777
            .::..:..|  .||:||.....:   |.::.|:.|
  Fly   762 EDQKNSVRQ--ENPIYRDPVGRYEVPKALSVKYDE 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgb6	NP_001153036.1	INB	30..454	CDD:197563	148/432 (34%)
		Cysteine-rich tandem repeats	456..619		63/181 (35%)
		I-EGF_1	456..485	CDD:408172	10/34 (29%)
		exchanger_TraA	<467..>646	CDD:411343	66/203 (33%)
		Integrin_B_tail	624..705	CDD:400356	19/102 (19%)
		Integrin_b_cyt	730..773	CDD:400871	12/45 (27%)
		Interaction with HAX1. /evidence=ECO:0000250	730..757		7/26 (27%)
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	149/434 (34%)
		EGF_2	524..552	CDD:285248	13/31 (42%)
		Integrin_b_cyt	748..785	CDD:285884	11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850270
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740