Protein Alignment Itgb3 and Itgbn

DIOPT Version :10

• Sequence 1: NP_058060.2
• Gene: Itgb3 / 16416
• MGIID: 96612
• Length: 787
• Species: Mus musculus
• Sequence 2: NP_523608.2
• Gene: Itgbn / 35368
• FlyBaseID: FBgn0010395
• Length: 799
• Species: Drosophila melanogaster
• Alignment Length: 810
• Identity: 258/810 - (31%)
• Similarity: 392/810 - (48%)
• Gaps: 76/810 - (9%)

Mouse     9 LWAALLALGALAGVVVGESNICTTRGVNSCQQCLAVSPVCAWCSDETLSQGSPRCNLKENLLKDN 73
            ||..|:.|.|.......:|.....|..:||::||:....||||:|:....|. ||..:..||..|
  Fly    10 LWIYLVFLIAEISHSDADSIDDQCRHADSCERCLSAHLECAWCTDKEYQVGY-RCLSRRQLLNYN 73

Mouse    74 CAPESIEFPVSEAQILEARPLSSKGSGSSAQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVD 138
            |:...|........:|:.:||  |...:|.|..||:|||..|:|...:::...|..|...:.|:|
  Fly    74 CSETDIYENQPVLDVLQDKPL--KDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLD 136

Mouse   139 IYYLMDLSFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMYISPPQAIKNPCY 203
            :|.||||:::|:||..:::.||.:|:..::.||.|.|:|||:|.|||..|.:.   ||..:|||.
  Fly   137 LYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMIL---PQHRENPCA 198

Mouse   204 NMKNACLPMFGYKHVLTLTDQVSRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDAS 268
            ..:..|.|.:||:|.|:|||.:..|...|....::.|.|..|||.||:||..||.::|||:..|.
  Fly   199 AERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQAR 263

Mouse   269 HLLVFTTDAKTHIALDGRLAGIVLPNDGHCHIGTDNHYSASTTMDYPSLGLMTEKLSQKNINLIF 333
            .:::..||...|:|.||.||||:..||..||:.....|:.|...|||||..:..:|.::.||:||
  Fly   264 KVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIF 328

Mouse   334 AVTENVVSLYQNYSELIPGTT-VGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNA 397
            ||||.|||.|...|.|:...: |.:||.||||:|:||..:|..:..:.:. ..:.|:.:.:::..
  Fly   329 AVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQF-ADNSPDFIDMAYYT 392

Mouse   398 TCLNNEVIPGLKS---CVGLKIGDTVSFSIEAKVRGCPQEKEQSFT----IKPVGFKDSLTVQVT 455
            .|  ....|.|:.   |..:.:|..:.|.::..::..|.  .|.:|    ::.....:.:.:.|.
  Fly   393 DC--GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPD--NQVYTHKIRVEETSLSEFMDLDVE 453

Mouse   456 FDCDCACQAFAQPSSPR----CNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEG 516
            ....|.||....|.:..    |:. .|...||:|.||:||.|:.|.|..:....:..|....|..
  Fly   454 LQRPCPCQETPDPENEEGRFLCDY-KGYLYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCR 517

Mouse   517 QP---------ICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCNCGDC 572
            ||         :||..|:|.||.|:|   |.| .||.:|||.:  |:....::    ..|.||.|
  Fly   518 QPFSDKSTSELVCSNHGDCDCGTCLC---DPG-YTGPFCECRE--CLDCDEKL----ADCFCGQC 572

Mouse   573 VCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCEKCPTCPD-ACSFK 636
            ||...|:|..|||...||.|:...|.:||.||.|:|..|.|.:| ..|..||..|...: .|.|.
  Fly   573 VCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKFCEIDPEKDNKLCLFY 636

Mouse   637 KECVECKKFNRGTLHEENTCSRYCRDDIEQVKELTDTGKNAVNCTYK---NEDDCVVR------- 691
            :.||.|       |.|:......|.:..|....|........|..::   .:|.|:||
  Fly   637 EPCVTC-------LIEQKQGMGVCENLTEICSSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGI 694

Mouse   692 ----FQYYE--DTSGRAVLYVVE-EPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDR 749
                |..|:  |.|....:..|: ||     ||.:.::..:....|||||..:.|....|...|.
  Fly   695 QCDSFFVYQVIDHSNFLTIQAVDCEP-----PDYVALVGYISAFTLLIGLLIIFIILWYIRAKDA 754

Mouse   750 KEFAKFEEERARAKWDTANNPLYKEATSTF 779
            :|:|||||::..:.  ...||:|::....:
  Fly   755 REYAKFEEDQKNSV--RQENPIYRDPVGRY 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itgb3	NP_058060.2	INB	37..460	CDD:197563	146/430 (34%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05106	202..209		1/6 (17%)
		Involved in CX3CL1-, NRG1-, FGF1-and IGF1-binding. /evidence=ECO:0000250|UniProtKB:P05106	202..209		1/6 (17%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05106	292..312		6/19 (32%)
		I-EGF_1	462..491	CDD:465729	10/32 (31%)
		Integrin_B_tail	633..716	CDD:462325	22/99 (22%)
		Integrin_b_cyt	744..784	CDD:462580	11/36 (31%)
		LIR. /evidence=ECO:0000250|UniProtKB:P05106	776..782		0/4 (0%)
Itgbn	NP_523608.2	INB	38..460	CDD:197563	147/432 (34%)
		EGF_2	529..552	CDD:400365	12/26 (46%)
		Integrin_b_cyt	752..785	CDD:462580	10/33 (30%)