DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Itgb2l and Itgbn

DIOPT Version :9

Sequence 1:	XP_006522991.1	Gene:	Itgb2l / 16415	MGIID:	1277979	Length:	795	Species:	Mus musculus
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	760	Identity:	199/760 - (26%)
Similarity:	332/760 - (43%)	Gaps:	120/760 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    29 NVSTCQDCIRSGPSCAWCQKLNFTGRGEPDSVRCDTPEQLLLKGCTSEYLVDPKSLAESQEDK-- 91
            :..:|:.|:.:...||||     |.:......||.:..|||...|:...:.:.:.:.:..:||
  Fly    35 HADSCERCLSAHLECAWC-----TDKEYQVGYRCLSRRQLLNYNCSETDIYENQPVLDVLQDKPL 94

Mouse    92 ----ERDQR-QLSPRNVTVFLRPGQAATFKVDFQRTQDNSVDLYFLMGLSGSAQGHLSNVQTLGS 151
                ..||. |::|:...:.|..|.....|:.::..::|.:|||.||.|:.:.:.....::.||:
  Fly    95 KDYETSDQAVQVTPQRAYLKLVKGNTQRMKLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGA 159

Mouse   152 DLLKALNEISRSGRIGFGSIVNMT--------------------------FQHILKLTADSSQFQ 190
            .|.:.|..::.:.|:||||..:..                          ::|.|.||.|...|.
  Fly   160 QLSQTLKNLTGNYRLGFGSFADKPTLPMILPQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFT 224

Mouse   191 RELRKQLVSGKLATPKGQLDAVVQVAICLGEIGWRNGTR-FLVLVTDNDFHLAKDKTLGTRQNTS 254
            ..:....::|.|...:|.|||::||.:|..||||:...| .::||||...|||.|..|......:
  Fly   225 SAVANSKITGNLDNLEGGLDALMQVIVCTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRN 289

Mouse   255 DGRCHLDD-GMYRSRGEPDYQSVVQLASKLAENNIQPIFVVPSRMVKTYEKLTTFIPKLT-IGEL 317
            |.:|||:. |.|......||.|:.::..:|....|..||.|...:|.:|.:|:..:.::: :..|
  Fly   290 DKQCHLNKAGEYTGSLNYDYPSLEEIYRELLRRKINVIFAVTEEVVSSYWELSALMKEISYVDIL 354

Mouse   318 SDDSSNVAQLIRNAYSKLSSIVVLNHSTIPSILKVTYDSYCSNGTSNPG-KPSGDCSGVQINDQV 381
            |.||||:.:||:.:|..|........:: |..:.:.|.:.|  |...|. :....|:.|.:..|:
  Fly   355 SADSSNILELIKKSYESLIKRTQFADNS-PDFIDMAYYTDC--GGQFPSLQKRNYCNNVTLGKQI 416

Mouse   382 TFQVNITASECFREQFFF-------IQALGFMDSVTVRVLPLCECQ---CQEQSQHHSLCGGKGA 436
            .|.|::|..:....|.:.       .....||| :.|.:...|.||   ..|..:...||..||.
  Fly   417 DFYVDVTLKKYPDNQVYTHKIRVEETSLSEFMD-LDVELQRPCPCQETPDPENEEGRFLCDYKGY 480

Mouse   437 MECGICRCNSGYAGKNCECQTQG---PSSQDLEGSCR-----KDNSSIMCSGLGDCICGQCECHT 493
            :.||:|.|:.|:.|..|.|.|..   .|::.|...||     |..|.::||..|||.||.|.|
  Fly   481 LYCGMCECDEGWTGTYCNCPTDATNVTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLC-- 543

Mouse   494 SDIPNKEIYGQYCECNN-VNCERYDGQVCGGPERGHCSCGRCFCRYGFVGSACQCRMSTSGCLNN 557
                :....|.:|||.. ::|:.         :...|.||:|.|:||:.||.|.|...|..|:..
  Fly   544 ----DPGYTGPFCECRECLDCDE---------KLADCFCGQCVCKYGWSGSKCNCDGDTDACVGP 595

Mouse   558 RMVECSGHGRCYCNRCLCDPGYQPPLCEKRPGYFHR-CSEYYSCARCLKDN-------------- 607
            ....||..|.|.|..|.|:..|....||..|...:: |..|..|..||.:.
  Fly   596 TGEICSERGTCQCEECQCEEPYLGKFCEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEIC 660

Mouse   608 SAIKCREC--WNLLFSNTPFSNKTCMTERDSEG--CWTTYTLYQP-DQSDINSIYIKESLVC--- 664
            |::..:|.  :|.:....|..::..:...:..|  | .::.:||. |.|:..:|   :::.|
  Fly   661 SSLDRQETYPYNFVHELDPEQDQCLVRLVNKHGIQC-DSFFVYQVIDHSNFLTI---QAVDCEPP 721

Mouse   665 ------AEISNTTILLGVIVGVLLAVIFLLVYCMVYLKGTQKAAK 703
                  ..||..|:|:|      |.:||:::: .:..|..::.||
  Fly   722 DYVALVGYISAFTLLIG------LLIIFIILW-YIRAKDAREYAK 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgb2l	XP_006522991.1	vWFA	32..419	CDD:381780	111/430 (26%)
		I-EGF_1	417..448	CDD:375798	12/33 (36%)
		Integrin_B_tail	594..666	CDD:369622	17/99 (17%)
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	111/430 (26%)
		EGF_2	524..552	CDD:285248	11/33 (33%)
		Integrin_b_cyt	748..785	CDD:285884	3/12 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780