DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgb1 and Itgbn

DIOPT Version :9

Sequence 1:	NP_034708.1	Gene:	Itgb1 / 16412	MGIID:	96610	Length:	798	Species:	Mus musculus
Sequence 2:	NP_001303333.1	Gene:	Itgbn / 35368	FlyBaseID:	FBgn0010395	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	841	Identity:	271/841 - (32%)
Similarity:	408/841 - (48%)	Gaps:	119/841 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 WIGLISLICSVFGQTD----KNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARCDDLE 68
            ||.|:.||..: ..:|    .::|  .:|.||..|:.|...|.|||:..: |.|.    ||....
  Fly    11 WIYLVFLIAEI-SHSDADSIDDQC--RHADSCERCLSAHLECAWCTDKEY-QVGY----RCLSRR 67

Mouse    69 ALKKKGCQPSDIENPRGSQTIKKNKNVTN--RSKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKF 131
            .|....|..:|         |.:|:.|.:  :.|.:.:....:...|:.||:..|||..|..|:.
  Fly    68 QLLNYNCSETD---------IYENQPVLDVLQDKPLKDYETSDQAVQVTPQRAYLKLVKGNTQRM 123

Mouse   132 TLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYI 196
            .|.::.|.:.|:|||.||||:::|:||.:.::.||..|...::.:|.::|:|||||.:|..:|.|
  Fly   124 KLSYRTARNNPLDLYVLMDLTWTMRDDKKTLEELGAQLSQTLKNLTGNYRLGFGSFADKPTLPMI 188

Mouse   197 STTPAKLRNPCTSEQ-NCTSPFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAV 260
              .|....|||.:|: .|...:.|::.|||||....|...|...:|:||||:.|||.||:|||.|
  Fly   189 --LPQHRENPCAAERATCEPTYGYRHQLSLTDDIPAFTSAVANSKITGNLDNLEGGLDALMQVIV 251

Mouse   261 CGSLIGWRNVTR-LLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLEN-NVYTMSHYYDYPSIAHLV 323
            |...|||:...| :::..||...|.||||.|.||:..||.||||.. ..||.|..|||||:..:.
  Fly   252 CTKEIGWKEQARKVVILVTDGFMHLAGDGLLAGIIQRNDKQCHLNKAGEYTGSLNYDYPSLEEIY 316

Mouse   324 QKLSENNIQTIFAVTEEFQPVYKELKNLIPK-SAVGTLSGNSSNVIQLIIDAYNSLSSEV-ILEN 386
            ::|....|..|||||||....|.||..|:.: |.|..||.:|||:::||..:|.||.... ..:|
  Fly   317 RELLRRKINVIFAVTEEVVSSYWELSALMKEISYVDILSADSSNILELIKKSYESLIKRTQFADN 381

Mouse   387 SKLPDGVTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESET--IKIKPLG 449
            |  ||.:.:.|.:.| .|...:.:....|:|:::|.::.|.:.:|..|.|:.:..|  |:::...
  Fly   382 S--PDFIDMAYYTDC-GGQFPSLQKRNYCNNVTLGKQIDFYVDVTLKKYPDNQVYTHKIRVEETS 443

Mouse   450 FTEEVEVVLQFICKCNCQSHGIPASPKCHEG------NGTFECGACRCNEGRVGRHCECSTDEVN 508
            .:|.:::.::....|.||.   ...|:..||      .|...||.|.|:||..|.:|.|.||..|
  Fly   444 LSEFMDLDVELQRPCPCQE---TPDPENEEGRFLCDYKGYLYCGMCECDEGWTGTYCNCPTDATN 505

Mouse   509 SEDMDAY---CR-----KENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCEC-DNFNCDRSN 564
            ....:|.   ||     |..|..:|||:|:|.||.|:|      :..|:|.|||| :..:||..
  Fly   506 VTSNEALLQKCRQPFSDKSTSELVCSNHGDCDCGTCLC------DPGYTGPFCECRECLDCDEK- 563

Mouse   565 GLICGGNGVCRCRVCECYPNYTGSACDCSLDTGPCLASNGQICNGRGICECGACKCTDPKFQGPT 629
                  ...|.|..|.|...::||.|:|..||..|:...|:||:.||.|:|..|:|.:| :.|..
  Fly   564 ------LADCFCGQCVCKYGWSGSKCNCDGDTDACVGPTGEICSERGTCQCEECQCEEP-YLGKF 621

Mouse   630 C--------------ETCQTCL-------GVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKV 673
            |              |.|.|||       |||....|.  |.:.::        ||...:|...
  Fly   622 CEIDPEKDNKLCLFYEPCVTCLIEQKQGMGVCENLTEI--CSSLDR--------QETYPYNFVH- 675

Mouse   674 ESREKLPQPVQVDP-----VTHCKEKDIDDCWFYFTYSVNGNNEAIVHVVETPDCPTGPDIIPIV 733
                      ::||     :.....|....|..:|.|.|..::..:  .::..||.. ||.:.:|
  Fly   676 ----------ELDPEQDQCLVRLVNKHGIQCDSFFVYQVIDHSNFL--TIQAVDCEP-PDYVALV 727

Mouse   734 AGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPK 794
            ..:.|..:||||.::.|....:...|.||:||||:::.|:.  ..|||||:..|.....||
  Fly   728 GYISAFTLLIGLLIIFIILWYIRAKDAREYAKFEEDQKNSV--RQENPIYRDPVGRYEVPK 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgb1	NP_034708.1	INB	34..464	CDD:197563	152/438 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..104		5/29 (17%)
		CX3CL1-binding. /evidence=ECO:0000250\|UniProtKB:P05556	207..213		2/6 (33%)
		CX3CL1-binding. /evidence=ECO:0000250\|UniProtKB:P05556	295..314		9/19 (47%)
		Cysteine-rich tandem repeats	466..635		65/197 (33%)
		I-EGF_1	466..495	CDD:375798	11/34 (32%)
		EGF_2	602..630	CDD:285248	11/27 (41%)
		Integrin_B_tail	640..727	CDD:369622	15/91 (16%)
		Integrin_b_cyt	757..795	CDD:370082	16/38 (42%)
		Signal for sorting from recycling endosomes, interaction with ACAP1. /evidence=ECO:0000250	762..767		3/4 (75%)
		Interaction with ITGB1BP1. /evidence=ECO:0000250	785..792		1/6 (17%)
Itgbn	NP_001303333.1	INB	38..460	CDD:197563	153/440 (35%)
		EGF_2	524..552	CDD:285248	12/33 (36%)
		Integrin_b_cyt	748..785	CDD:285884	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.730