DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTC24 and ssn6

DIOPT Version :9

Sequence 1:	NP_001099139.2	Gene:	TTC24 / 164118	HGNCID:	32348	Length:	582	Species:	Homo sapiens
Sequence 2:	NP_596609.1	Gene:	ssn6 / 2540656	PomBaseID:	SPBC23E6.09	Length:	1102	Species:	Schizosaccharomyces pombe

Alignment Length:	766	Identity:	152/766 - (19%)
Similarity:	242/766 - (31%)	Gaps:	281/766 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    10 PRRPEPEPSSSNKKKKKRKW-----------LRQEASIQALTRAGHGALQAGQ----------NH 53
            |::|:|......:::::|:.           :.|..:..::....|.  .|||          |.
pombe   186 PQQPQPPQQPLQQQQQQRQLHSGIQQPVSTIVSQNGTYYSIPAVNHP--MAGQPIAIAPVPAPNQ 248

Human    54 EALNNFQRAFLLASKAPQTRDTPVLQACAFNLGAAYVE----TGDPA------------------ 96
            .||.......|.|:..|.|..:||....| |......:    |..||
pombe   249 AALPPIPPQALPANGTPNTLASPVTLPAA-NSAVQNAQPVPMTSSPAMAVVPQNKTAATSTLAAQ 312

Human    97 RGLELLLRAHPEEKAQGRRH-------------------GDQCFNVALAYHALGELPQAL----- 137
            :|..:|    |....:..||                   .||...::....||.:.|.::
pombe   313 QGANVL----PPNAPESVRHLISLNEETWIQIGRLAELFDDQDKALSAYESALRQNPYSIPAMLQ 373

Human   138 --------AWYHRALGHYQPQGD----QGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQL 190
                    ..:..|:.:||...|    |||.|:.:|.||  |.|.:|        |:||:..||
pombe   374 IATILRNREQFPLAIEYYQTILDCDPKQGEIWSALGHCY--LMQDDL--------SRAYSAYRQ- 427

Human   191 RAAAL---------ALGAAAGCML-KSGRH------------------RVGEV------------ 215
               ||         .|....|.:. :.|.|                  :|.|:
pombe   428 ---ALYHLKDPKDPKLWYGIGILYDRYGSHEHAEEAFMQCLRMDPNFEKVNEIYFRLGIIYKQQH 489

Human   216 --VQVLEKSRRLAERSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQAL-----------PLCW 267
              .|.||..|.:.:...:...:..:|..:|..|.|.:.:.||.||:.:.|           .|.|
pombe   490 KFAQSLELFRHILDNPPKPLTVLDIYFQIGHVYEQRKEYKLAKEAYERVLAETPNHAKVLQQLGW 554

Human   268 VPGEQATVLRN------------------------LGMAHNALGNYQEAREFHQKAADLHGSVGQ 308
            :..:|::...|                        :|..:.|...|.:|.|.:|:|....|....
pombe   555 LCHQQSSSFTNQDLAIQYLTKSLEADDTDAQSWYLIGRCYVAQQKYNKAYEAYQQAVYRDGRNPT 619

Human   309 RWEQGRSFGSLAFALSQLGDHKAARDNYLHAL-------QAARDSGDMKGQWQACEGLGAAAARL 366
            .|   .|.|.|.:.::|..|   |.|.|..|:       :...|.|.:   :::|.
pombe   620 FW---CSIGVLYYQINQYQD---ALDAYSRAIRLNPYISEVWYDLGTL---YESCH--------- 666

Human   367 GQYDQALKYYKEALAQCQKEPDSVRERLVAKLA----------DTVRTRLAQVGLVQTHTLTSAP 421
            .|...||..|:.|     .|.|.....:.|:|.          ..|....:.|..|||....:.|
pombe   667 NQISDALDAYQRA-----AELDPTNPHIKARLQLLRGPNNEQHKIVNAPPSNVPNVQTAKYINQP 726

Human   422 GRLQAPGGASQAEGT-----------PAKAGSSTAGVQHRSSSGWEDEEFEEGHQKKKEERSAN- 474
            |...:....:|..|.           |:..|.|  ||            .::.:|.:....:.|
pombe   727 GVPYSNVPVAQLSGNWQPPHLPQAQLPSATGQS--GV------------VQQPYQTQPSVTNNNV 777

Human   475 ---------VPVR-AGPGRPELCFLPGTVNHSHHLASSCPTFT---KHTPCRGTVLGKASIYSPG 526
                     |||: |.|.....  :|.|::.|:       .||   ||  ..|:....:|..||.
pombe   778 ATQPVIASTVPVQTAAPSSQTA--VPQTIHQSN-------AFTPRGKH--ASGSRNSISSTKSPQ 831

Human   527 PRAHLPFVGPGPPRAEYPSILVPNGPQANRSSRWPRESL-SRSRQRRPMES 576
            .:.      ...||:...||       :|.|.|....|: |:||:.|...|
pombe   832 HKL------SDQPRSRNNSI-------SNVSHRERSNSVSSKSRETRTSAS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTC24	NP_001099139.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		4/31 (13%)
		TPR_12	36..105	CDD:290160	20/100 (20%)
		TPR 1	36..69		9/42 (21%)
		TPR repeat	36..64	CDD:276809	7/37 (19%)
		TPR 2	79..112		8/54 (15%)
		TPR_12	80..148	CDD:290160	16/121 (13%)
		TPR repeat	81..111	CDD:276809	8/51 (16%)
		TPR repeat	116..146	CDD:276809	7/61 (11%)
		TPR 3	117..150		8/45 (18%)
		TPR_11	121..180	CDD:290150	17/75 (23%)
		TPR 4	154..187		12/32 (38%)
		TPR repeat	154..180	CDD:276809	9/25 (36%)
		TPR_12	232..302	CDD:290160	20/104 (19%)
		TPR 5	236..271		11/45 (24%)
		TPR repeat	238..264	CDD:276809	9/36 (25%)
		TPR_12	271..345	CDD:290160	20/104 (19%)
		TPR 6	273..306		9/56 (16%)
		TPR	273..302	CDD:197478	8/52 (15%)
		TPR repeat	273..301	CDD:276809	8/51 (16%)
		TPR repeat	312..342	CDD:276809	9/36 (25%)
		TPR 7	313..346		9/39 (23%)
		TPR_12	314..385	CDD:290160	17/77 (22%)
		TPR 8	353..386		6/32 (19%)
		TPR repeat	353..381	CDD:276809	6/27 (22%)
		TPR_1	353..>380	CDD:278916	5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..481		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..582		9/30 (30%)
ssn6	NP_596609.1	TPR repeat	335..362	CDD:276809	3/26 (12%)
		TPR	346..679	CDD:223533	74/364 (20%)
		TPR repeat	367..397	CDD:276809	3/29 (10%)
		TPR_17	390..421	CDD:290167	14/40 (35%)
		TPR repeat	403..430	CDD:276809	14/40 (35%)
		TPR repeat	437..467	CDD:276809	4/29 (14%)
		TPR_1	438..471	CDD:278916	4/32 (13%)
		TPR repeat	472..503	CDD:276809	6/30 (20%)
		TPR repeat	512..540	CDD:276809	8/27 (30%)
		TPR	513..545	CDD:197478	9/31 (29%)
		TPR_11	546..611	CDD:290150	10/64 (16%)
		TPR repeat	546..578	CDD:276809	4/31 (13%)
		TPR_1	584..617	CDD:278916	8/32 (25%)
		TPR repeat	584..612	CDD:276809	7/27 (26%)
		TPR repeat	617..647	CDD:276809	10/35 (29%)
		TPR_1	621..649	CDD:278916	10/33 (30%)
		TPR_1	652..686	CDD:278916	10/50 (20%)
		TPR repeat	652..681	CDD:276809	8/45 (18%)
		MIP-T3	841..>1097	CDD:287245	11/36 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900