DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTC24 and utx-1

DIOPT Version :9

Sequence 1:	NP_001099139.2	Gene:	TTC24 / 164118	HGNCID:	32348	Length:	582	Species:	Homo sapiens
Sequence 2:	NP_001309685.1	Gene:	utx-1 / 181110	WormBaseID:	WBGene00017046	Length:	1146	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	74/382 - (19%)
Similarity:	128/382 - (33%)	Gaps:	119/382 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    27 RKWLRQEASIQALTRAGHGALQAGQNHEALNNFQRAFLLASKAPQTRDTPVLQACAFNLGAAYVE 91
            ::|   :.:|:|.||             .|.:|....:            .||| ...||..|:|
Worm   153 KQW---KPAIEAFTR-------------LLYSFPTGMI------------ALQA-KVRLGVCYME 188

Human    92 TGDPARGLELL-LRAHPEEKAQGRRHGDQCFNVALAYHALGELPQALAWYHRALGHYQPQGDQGE 155
            ..|..|.:.|. |..:..:::.........:|:||::....||..|.:.|...:
Worm   189 LEDYNRCINLFKLAVNDSDESVFMPKFTIKYNIALSHENNDELEIAESEYENLI----------- 242

Human   156 AWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAALALGAAAGCMLKSG----RHRVGEVV 216
                          .||..|.....|::...::|:   .|.:...|.|:.:.|    |....:..
Worm   243 --------------TELTQHISFLQSKSNVDQQQV---DLLISVKAACLRQIGWISYRRSYKDDA 290

Human   217 QVLEKSRRLAE-----RSTERRLLGHLYNDLGLGYSQLQLFPLAVEAFLQALPLCWVPGEQATVL 276
            ..|:..::..|     ..|:.| .|..|..||..|.:.:                  |.....|
Worm   291 NRLDHLKKAQENLISAHDTDPR-DGQSYYYLGRVYGEHE------------------PSVSGQV- 335

Human   277 RNLGMAHNALGNYQEAREFHQKAADLHGSVGQRWE-QGRSFGSL-AF--ALSQLGDHKAARDNYL 337
                 ||:|..||:.:.:..::.||...|:|..:: |.:...:| ||  |:.....|.||
Worm   336 -----AHDAFVNYRFSIDKKEQNADTWCSIGALYQRQNQPIDALQAFICAIELNSTHSAA----- 390

Human   338 HALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRERL 394
                           |   ..||....:..||..||:.:|.|:......|:.::.|:
Worm   391 ---------------W---TDLGELYEKNAQYQDALECFKNAMLNNPVAPEPIKARV 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTC24	NP_001099139.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		1/3 (33%)
		TPR_12	36..105	CDD:290160	17/69 (25%)
		TPR 1	36..69		6/32 (19%)
		TPR repeat	36..64	CDD:276809	6/27 (22%)
		TPR 2	79..112		10/33 (30%)
		TPR_12	80..148	CDD:290160	16/68 (24%)
		TPR repeat	81..111	CDD:276809	8/30 (27%)
		TPR repeat	116..146	CDD:276809	7/29 (24%)
		TPR 3	117..150		7/32 (22%)
		TPR_11	121..180	CDD:290150	10/58 (17%)
		TPR 4	154..187		4/32 (13%)
		TPR repeat	154..180	CDD:276809	3/25 (12%)
		TPR_12	232..302	CDD:290160	14/69 (20%)
		TPR 5	236..271		6/34 (18%)
		TPR repeat	238..264	CDD:276809	4/25 (16%)
		TPR_12	271..345	CDD:290160	18/77 (23%)
		TPR 6	273..306		8/32 (25%)
		TPR	273..302	CDD:197478	7/28 (25%)
		TPR repeat	273..301	CDD:276809	6/27 (22%)
		TPR repeat	312..342	CDD:276809	8/32 (25%)
		TPR 7	313..346		7/35 (20%)
		TPR_12	314..385	CDD:290160	16/73 (22%)
		TPR 8	353..386		9/32 (28%)
		TPR repeat	353..381	CDD:276809	9/27 (33%)
		TPR_1	353..>380	CDD:278916	8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..481
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..582
utx-1	NP_001309685.1	TPR_11	138..204	CDD:290150	18/79 (23%)
		TPR repeat	138..168	CDD:276809	6/30 (20%)
		TPR repeat	176..203	CDD:276809	11/27 (41%)
		TPR repeat	271..301	CDD:276809	5/29 (17%)
		TPR repeat	315..348	CDD:276809	11/56 (20%)
		TPR_11	353..419	CDD:290150	21/88 (24%)
		TPR repeat	353..383	CDD:276809	9/29 (31%)
		TPR_1	354..387	CDD:278916	9/32 (28%)
		TPR repeat	388..415	CDD:276809	10/49 (20%)
		TPR	390..419	CDD:197478	10/51 (20%)
		JmjC	845..909	CDD:214721
		JmjC	879..987	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900