Protein Alignment DCX and CaMKII

DIOPT Version :10

• Sequence 1: NP_000546.2
• Gene: DCX / 1641
• HGNCID: 2714
• Length: 441
• Species: Homo sapiens
• Sequence 2: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 318
• Identity: 54/318 - (16%)
• Similarity: 114/318 - (35%)
• Gaps: 79/318 - (24%)

Human    69 DRSHC-----QSLRF-HQNMELDFGHFDERDKTSRNM------RGSRMN----GLPSPTHSAHCS 117
            |.|||     :|:.. |||..:      .||....|:      :|:.:.    ||.......|.:
  Fly   112 DASHCIQQILESVNHCHQNGVV------HRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQA 170

Human   118 FYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAV---------SSDRFRSFDALLA---DLTR 170
            ::.........:.:..||..:.::.|.:..|::..:         ..|:.|.:..:.|   |...
  Fly   171 WFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPS 235

Human   171 SLSDNINLPQG---VRYIYTIDGSRKIGSMDELEEGESYVCSSDNFF------KKVEYTKNVNPN 226
            ...|.:. |:.   :..:.|::.:::|.:.:.|:  ..::|..:...      :.|:..|..|..
  Fly   236 PEWDTVT-PEAKNLINQMLTVNPNKRITAAEALK--HPWICQRERVASVVHRQETVDCLKKFNAR 297

Human   227 WSVNVKTSANMKAPQSLAS-----------------SNSAQARENKDFVRPKLVTIIRSGV---K 271
            ..:.......|.|.::.:|                 .:|:...|:.|....|..|:.||..   |
  Fly   298 RKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSK 362

Human   272 PRKAVRVLLNKKTAHSFEQVLTDI--------TEAIKLETGVVKKLYT--LDGKQVTC 319
            ..:.:|:|...||   ::|.:.:.        .|.||:...:::.:.:  .||....|
  Fly   363 EPEDIRILCPAKT---YQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKIC 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCX	NP_000546.2	DCX1_DCX	132..220	CDD:340529	15/108 (14%)
		DCX2	257..340	CDD:340589	16/76 (21%)
		KLF8_12_N	<365..>419	CDD:424081
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	32/199 (16%)
		CaMKII_AD	390..517	CDD:285524	6/28 (21%)