DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itga6 and if

DIOPT Version :9

Sequence 1:	NP_001264899.1	Gene:	Itga6 / 16403	MGIID:	96605	Length:	1091	Species:	Mus musculus
Sequence 2:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster

Alignment Length:	1480	Identity:	338/1480 - (22%)
Similarity:	548/1480 - (37%)	Gaps:	532/1480 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 LLARLGTAFNLDTREDNVIRKSGDPGSLFGFSLAMHWQLQ----PEDKRLLLVGAPRAEALPLQR 76
            |:|.....:|:|.  .:.:|......|:||||:|||....    .::...|:||||:.:....|:
  Fly    24 LIAMSAHGYNIDL--PSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQ 86

Mouse    77 -ANRTGGLYSCDITSRGPCTRIEFDNDADPMSESKE------DQWMGVTVQSQGPGGKVVTCAHR 134
             ....||::.|.:.. ..|..:.||:..:..:..||      .||:|.||.:......||.||.|
  Fly    87 GVTEAGGVFKCSLND-DDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPR 150

Mouse   135 YEKRQHVNTKQESR----DIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAAT 195
            |.    .:|...||    |..|.|:. |.|..     :..:.|.|.....|:.:.||||.|.:|.
  Fly   151 YV----FHTMTPSRAFRIDPVGTCFT-SHNFE-----EFYEVSPCRTNNWGYHRQGSCQAGFSAA 205

Mouse   196 FTKDFHYIVFGAPGTYNWKGIVRVEQKNNTF-FDMNIFEDGPYEVGG-ETDHDESLVPVPAN--- 255
            ...:...:..||||::.|:|.......:..| |...:::  |:..|| .:.||   |..|.|
  Fly   206 INGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQ--PFGTGGMASSHD---VTRPENQVF 265

Mouse   256 -----------SYLGFSLDSG--KGIVSKDDITFVSGAPR-ANHSGAVVLLKRDMKSAHLLPEYI 306
                       ||||:|:.:|  .|..|:|   ...|.|| .|..|.:|:.:.:|.:       |
  Fly   266 STSESASVNDDSYLGYSMVTGDFDGDRSED---VAIGMPRGGNLVGRIVVNRWNMAN-------I 320

Mouse   307 FD--GEGLASSFGYDVAVVDLNADGWQDIVIGAPQYFDRDGEVG----GAVYVYI----NQQGKW 361
            |:  |..:...|||.:|..|::.||..|::||||.|.|.|...|    |.||:.:    .::.:|
  Fly   321 FNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRW 385

Mouse   362 SNVKPIRLNGTKDSMFGISVKNIGDINQDGYPDIAVGAPYD---DLGKVFIYHGSPTGIITKPTQ 423
            : .:.||........||:::..:||:|.|||.|.|||||||   ..|.|:|:||||.|.:.||:|
  Fly   386 T-TEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQ 449

Mouse   424 VL------EGTSPY---FGYSIAGNMDLDRNSYPDLAVGSL-SDSVTIFRSRPVINILKTITVTP 478
            ::      || :||   ||::::|.:|:|.|:|||||||:. ||.|.||:||||..:....:...
  Fly   450 IIKSEQLVEG-APYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFAS 513

Mouse   479 N----RIDLRQKSMCGSPSGI-CLKVKACFEYTAKPSGYNP---PISILGILEAEKERRKSGLSS 535
            |    .:|.|...:......: |:.:..|:.||.:   |.|   ...:..:|:|:|.     |:.
  Fly   514 NSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGR---YLPEQLDFDVSWLLDAKKL-----LNP 570

Mouse   536 RVQF-RNQGSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQ-----EPSSR 594
            |:.| |::|...: .|.:.|| ..|:.|:.||::|.:.::|||.|:.:.|...::     :|..|
  Fly   571 RMFFLRDEGKNIR-NQTIRLN-YGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVR 633

Mouse   595 RRVNSLPEVLPILNSNEAKTVQTDVHFLKEGCGDDNVCNSNLKLEYKFGTREGNQDKFSYLPIQK 659
            .|.:.|.   |:::.|. :.|..|...:::.||.||:|..:|||      :....||:.:
  Fly   634 HRRSILE---PVIDQNR-EIVLRDAINIQKNCGPDNICEPDLKL------KVSTVDKYLF----- 683

Mouse   660 GIPELVLKDQKDIALEITVTNSPSDPRNPRKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQL 724
            |.||       .:.:|:.::|:          .:||.||......|..|.:...::|....:..:
  Fly   684 GSPE-------PLVIEVFISNT----------NEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPI 731

Mouse   725 SC--VANQNGSQADCELGNP--------FK----------RNSSVTFYLILSTTEV-----TFDT 764
            :|  ...:|.....|::|||        ||          .:||..||...::|.:     .:|.
  Fly   732 TCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDN 796

Mouse   765 -----------TDLDIN---------------LKLETTSNQDNLAP--------------ITAKA 789
                       |||||.               .:||..:.:|::.|              |..:|
  Fly   797 KIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEA 861

Mouse   790 KVVIELLLSVSGVAKPSQVYFGGTVVGEQAM--KSEDEVGSLIEYE---FRVINL---GKPLKN- 845
            :|.|.|         |.:     |:||:..|  .::.|.|..|:.:   |...||   .|.:|.
  Fly   862 EVFIHL---------PYE-----TIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKS 912

Mouse   846 --------LGTATLNIQWPKEISNGKWLLYLMKVESKGL-------------------------- 876
                    ..:|.::.|.....|:|...:::.|...:|.
  Fly   913 YLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQ 977

Mouse   877 ------------------EQIVCEP----------------------------HNEINYLKL--- 892
                              .|.|.||                            |:...::::
  Fly   978 EDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMAGP 1042

Mouse   893 ---KESHNSRKKRELPEKQ----------------------IDDSRKF----------------- 915
               ..|.:|...|..|.:|                      .:|..:|
  Fly  1043 VQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTGTLDLGTL 1107

Mouse   916 --------------------------------------------SLFPERK-------------- 922
                                                        :.|..|.
  Fly  1108 NRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQTSYQGQTQ 1172

Mouse   923 -------YQT------------------------------------------------------- 925
                   |||
  Fly  1173 YSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRRLRRSNDK 1237

Mouse   926 -------LNCSVN-----VRCVNIRCPLRGL---DSKASLV-LRSRLWNSTFLEEYSKLNYLDIL 974
                   |...:|     .||.:|||.:..|   |..|:.| :|:|:...| :|:.:.    ::.
  Fly  1238 DGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKT-MEKLAS----NVP 1297

Mouse   975 LRASIDVTAAAQNIK-LPHAGTQVRVTVFPSKTVAQ-----YSG----------VAWWIILLAVL 1023
            |..|   |.|..|:. ||..|.       |...:.:     |..          |..|:::||..
  Fly  1298 LNVS---TLAVANVTLLPFIGA-------PKDAIVKTHEIFYKAEPEPLQVPDVVPLWVVVLAAC 1352

Mouse  1024 AGILMLALLVFLLWKCGFFKRSRYDDSIPRYHAVRIRKEEREIKDEKHMD 1073
            ||.|:..|||:||:|||||.|:|     |..|:    :|.:.:::..|.|
  Fly  1353 AGALIFLLLVWLLYKCGFFNRNR-----PTDHS----QERQPLRNGYHGD 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itga6	NP_001264899.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..95		18/69 (26%)
		Int_alpha	40..100	CDD:214549	18/64 (28%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..166		21/74 (28%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	176..229		15/53 (28%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	244..300		21/72 (29%)
		Int_alpha	254..>292	CDD:214549	16/54 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	301..363		23/71 (32%)
		Int_alpha	314..359	CDD:214549	19/52 (37%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	364..419		26/57 (46%)
		Int_alpha	374..425	CDD:214549	27/53 (51%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	420..479		29/68 (43%)
		Int_alpha	431..>454	CDD:214549	13/25 (52%)
		Integrin_alpha2	464..939	CDD:369878	133/819 (16%)
		GFFKR motif	1040..1044		3/3 (100%)
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	18/64 (28%)
		Int_alpha	275..>316	CDD:214549	15/43 (35%)
		Int_alpha	398..451	CDD:214549	27/52 (52%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	100/449 (22%)
		DUF2756	<1120..1178	CDD:298627	2/57 (4%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832107
Domainoid	1	1.000	57	1.000	Domainoid score	I10823
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740