DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itga6 and mew

DIOPT Version :9

Sequence 1:	NP_001264899.1	Gene:	Itga6 / 16403	MGIID:	96605	Length:	1091	Species:	Mus musculus
Sequence 2:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster

Alignment Length:	1270	Identity:	349/1270 - (27%)
Similarity:	551/1270 - (43%)	Gaps:	319/1270 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 CLLYLSAGLLARLG---TAFNLDTREDNVIRKSGDPGSLFGFSLAMHWQLQ---PEDKRLLLVGA 66
            |.|..:.|:|..|.   |.:|.:..:...|.|.|.|.|.||:|:|.|...:   |.....:||||
  Fly    13 CRLRQNLGILIILQCVLTCYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLVGA 77

Mouse    67 PRAEALPLQRANRT--GGLYSCDITSR-GPCTRIEFDN----DADPMS-----ESKEDQWMGVTV 119
            |..:.   ::.|.|  |.|:.|.:|.| ..|.::..|.    |::.:|     |.||||||||||
  Fly    78 PLDQN---RQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGVTV 139

Mouse   120 -----QSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGR- 178
                 |:.|.||||:.|||||     :...:|:|...|.||:|:.:|:.|:..:.     |.||
  Fly   140 RSNPLQANGSGGKVIVCAHRY-----MYIVRENRYGQGLCYLLTNDLQFEEVHEP-----CKGRP 194

Mouse   179 -LRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGE 242
             .|.||.:|.||.|.:|....| ..:|.|:||.|.|:|.:.|.|                 ||||
  Fly   195 VQRQHEDYGLCQAGTSAALLDD-DTMVLGSPGPYTWRGSIWVTQ-----------------VGGE 241

Mouse   243 ----------TDHDESLVPVPANSYLGFSLDSGKGIVSKDDITFVSGAPRANHSGAVVLLKRDMK 297
                      :||.:...||...||||.|:..|:..   ..:::.:||||:...|.||:.  |..
  Fly   242 YLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTGGRFF---GHMSYAAGAPRSEGHGQVVIF--DKS 301

Mouse   298 SAHLLPEY-IFDGEGLASSFGYDVAVVDLNADGWQDIVIGAPQYFDRDGEVGGAVYVYINQQGKW 361
            :.:.:|.: |.|||...|||||::|..|:|.|...|:::.||.||.:  ..|||||||.|.|...
  Fly   302 TDNPIPVHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTK--TEGGAVYVYQNIQDTL 364

Mouse   362 SNVKPIRLNGTKDSMFGISVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLE 426
            .....::|.|..:|.||:::.||||:|:|...|:||||||:..|.|:||.||..|:.:||.|.::
  Fly   365 PMKYTLKLTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQ 429

Mouse   427 -----GTSP------YFGYSIAGNMDLDRNSYPDLAVGSL-SDSVTIFRSRPVINILKTI----- 474
                 ||.|      .||.||:||.|||.|||||:.:|:. |.:..|..:||:|:|..::
  Fly   430 ASELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKEL 494

Mouse   475 ----TVTPNRIDLRQKSMCGSPSG--ICLKVKACFE---YTAKPSGYNPPISILGILEAE----- 525
                ..||..:|        .|:.  .|...:||..   |..|    |..:.:...:|||
  Fly   495 HNMDPNTPGCLD--------DPASNLTCFTFRACCSIEPYDEK----NKELRLAYSVEAETFDHL 547

Mouse   526 ----------KERRKSGLSSRVQFRNQGSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPI 580
                      :|.:::.:.|||              :.::...:..|...|.:::.|.||...|:
  Fly   548 KKFSRVFFFDRENKRTNVLSRV--------------VRVHTNGRTECQAVTGYIKANTRDIQTPV 598

Mouse   581 PITASVEIQEP----SSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKEG-----CGDDNVCNSNL 636
            .......:.||    |:..|:|      |||:       ||..|...||     ||||::|.|||
  Fly   599 RFRLKYSLVEPPLADSALVRLN------PILD-------QTQAHVDFEGTFQKDCGDDDLCESNL 650

Mouse   637 KLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNSPSDPRNPRKDGDDAHEAKLI 701
            .:..:....|.:.::::          |:| |:.::.:.|.|:|.          .|.|:||:|.
  Fly   651 IIRVEPNITESSGNEYT----------LIL-DETELEVRINVSNL----------ADSAYEAQLF 694

Mouse   702 ATFPDTLTYSAYRELRAFPEKQLSCVANQ-NGSQADCELGNPFKRNSSVTFYLILSTTEVT--FD 763
            ......::|.|       .:|..:...|. |.:...|.||||..|:         :||.||  |.
  Fly   695 IAHQAGVSYVA-------TKKPTNATCNSYNTTLVACSLGNPMLRD---------TTTFVTIRFQ 743

Mouse   764 TTDLDINLKL-------ETTS--------NQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGT 813
            ...|:.:.|:       .|||        .:|....:..:||      |:..|.|.|.|.::.|:
  Fly   744 PKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVRRAK------LNFRGWAIPEQSFYSGS 802

Mouse   814 VVGEQAMKSE------------DEVGSLIEYEFRVINLGKPLKNLGTA---TLNIQWPKEI---- 859
            .|......:.            |:|||.:.:.|.:.|.|.     .||   .:.|.||..:
  Fly   803 SVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGP-----STAPKVQMVIHWPYSLYSDP 862

Mouse   860 SNGK---WLLYLMKVESKGLEQIVCEPHNE-INYLKLKESHNSRKK----------RELPEKQID 910
            .:|:   :||||.:|.:..:.|..|....| :|.|.|  :..||:.          |..|.:...
  Fly   863 QSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNL--ASGSRENPAYLSAPAQMRMFPSQSRH 925

Mouse   911 DSRKFSLFPERKYQT-------------------------------------------------- 925
            ...|..:..:|.|.:
  Fly   926 SFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDIV 990

Mouse   926 -LNCSVN-VRCVNIRCPLRGLD--SKASLVLRSRLWNSTFLEEYSKLNYLDILLRASIDVTAAAQ 986
             |:|:.. ..||.|.|.:..:.  |:|.:|:::||||||.:.||.::..:.|...|:..:..:..
  Fly   991 ELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYG 1055

Mouse   987 NIKLPHAGTQVRVTVFPS-KTVAQYSGVAWWIILLAVLAGILMLALLVFLLWKCGFFKRSRYDDS 1050
            ...:.|...:|....:|. :...:.:.:.|.||:|.::.|:|:|||:.::|||.|||||.|..|.
  Fly  1056 VEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDP 1120

Mouse  1051 IPRYHAVRIRKEEREIKDEKHMDNLEKKQWITKWN 1085
            ....:..::.:|:..:...|:..::..::....|:
  Fly  1121 TLSGNLEKMNEEKPFLAPSKNTHHVFXQEGTVGWD 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itga6	NP_001264899.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..95		23/70 (33%)
		Int_alpha	40..100	CDD:214549	21/65 (32%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..166		32/78 (41%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	176..229		20/54 (37%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	244..300		18/55 (33%)
		Int_alpha	254..>292	CDD:214549	13/37 (35%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	301..363		28/62 (45%)
		Int_alpha	314..359	CDD:214549	22/44 (50%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	364..419		25/54 (46%)
		Int_alpha	374..425	CDD:214549	26/50 (52%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	420..479		28/79 (35%)
		Int_alpha	431..>454	CDD:214549	14/22 (64%)
		Integrin_alpha2	464..939	CDD:369878	127/615 (21%)
		GFFKR motif	1040..1044		3/3 (100%)
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	21/65 (32%)
		Int_alpha	317..368	CDD:214549	23/52 (44%)
		Int_alpha	378..428	CDD:214549	26/49 (53%)
		Int_alpha	446..491	CDD:214549	21/44 (48%)
		Integrin_alpha2	479..1006	CDD:285619	127/615 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5179
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20091
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2011
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46425
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001200
OrthoInspector	1	1.000	-	-		otm43629
orthoMCL	1	0.900	-	-		OOG6_102503
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2587
SonicParanoid	1	1.000	-	-		X929
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860