Sequence 1: | NP_001230641.1 | Gene: | Itch / 16396 | MGIID: | 1202301 | Length: | 864 | Species: | Mus musculus |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_648993.1 | Gene: | Nedd4 / 39958 | FlyBaseID: | FBgn0259174 | Length: | 1007 | Species: | Drosophila melanogaster |
Alignment Length: | 1069 | Identity: | 344/1069 - (32%) |
---|---|---|---|
Similarity: | 468/1069 - (43%) | Gaps: | 336/1069 - (31%) |
- Green bases have known domain annotations that are detailed below.
Mouse 1 MSDSGPQLDSMGSLTMKSQLQITVISAKLKENKKNWFGPS-PYV---------EVTVDGQSKKTE 55
Mouse 56 KCNNTNSPKWKQPLTVIVTPTS-KLCFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMT 119
Mouse 120 LQLVGDKEPTETMGDLSVCLDGLQVEAEVVTNGETSCSESTTQNDDGCRTRDDTRVSTNGSEDPE 184
Mouse 185 VAASGENKRANGNNSPSLSNGGFKPSRPPRPSRPPPPTPR-RPASVNGSPSTNSDSDGSSTGSLP 248
Mouse 249 PTNTNVNTSTSEGATSGLIIPLTISGGSGPRPLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRT 313
Mouse 314 TWDRP------------EPLPPGWERR----VD--------------------NMGRIYY----- 337
Mouse 338 ---------------------------------VDH----------------------------- 340
Mouse 341 ----------------FTRTTT--------WQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY 381
Mouse 382 -----------------------GNQDLF-------------ATSQNKEFD-----PL------- 398
Mouse 399 -GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEK------------PLPEGWEMRFT 450
Mouse 451 VDGIPYFVDHNRRATTYIDPRTGKSALDN----GPQIAYVRDFKAKVQYFRFWCQQ-LAMPQHIK 510
Mouse 511 ITVTRKTLFEDSFQQIMSFSPQD-LRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFE 574
Mouse 575 YAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDL 638
Mouse 639 ESIDPEFYNSLIWVKENNIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVA 703
Mouse 704 EWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYR-HYTRTS 767
Mouse 768 KQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTC 832
Mouse 833 FNRLDLPPYKSYEQLKEKLLFAIEETEGF 861 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Itch | NP_001230641.1 | C2_E3_ubiquitin_ligase | 17..140 | CDD:175988 | 34/133 (26%) |
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 151..294 | 22/143 (15%) | |||
WW | 289..318 | CDD:278809 | 16/28 (57%) | ||
WW | 321..350 | CDD:278809 | 15/143 (10%) | ||
Required for interaction with FYN. /evidence=ECO:0000250 | 356..432 | 32/124 (26%) | |||
WW | 401..430 | CDD:278809 | 12/28 (43%) | ||
WW | 440..471 | CDD:197736 | 16/30 (53%) | ||
HECTc | 509..862 | CDD:238033 | 189/356 (53%) | ||
HECTc | 533..861 | CDD:214523 | 180/330 (55%) | ||
MAP kinase docking site | 535..544 | 4/8 (50%) | |||
Nedd4 | NP_648993.1 | C2_NEDD4_NEDD4L | 71..204 | CDD:175999 | 43/221 (19%) |
WW | 248..277 | CDD:278809 | 16/28 (57%) | ||
WW | 531..560 | CDD:278809 | 12/28 (43%) | ||
WW | 581..613 | CDD:197736 | 18/36 (50%) | ||
HECTc | 650..1003 | CDD:238033 | 187/354 (53%) | ||
HECTc | 674..1003 | CDD:214523 | 180/330 (55%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG5021 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 1 | 1.000 | - | - | FOG0000080 | |
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_100256 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2273 |
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
5 | 4.740 |