Protein Alignment DCTN1 and NIP100

DIOPT Version :9

• Sequence 1: NP_004073.2
• Gene: DCTN1 / 1639
• HGNCID: 2711
• Length: 1278
• Species: Homo sapiens
• Sequence 2: NP_015151.1
• Gene: NIP100 / 855929
• SGDID: S000006095
• Length: 868
• Species: Saccharomyces cerevisiae
• Alignment Length: 1097
• Identity: 192/1097 - (17%)
• Similarity: 347/1097 - (31%)
• Gaps: 443/1097 - (40%)

Human    41 RGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCD------EG--HGIFVRQSQIQVF 97
            :|.|.::|.|.||.|.|.|:.||:..|||||:..|.:||..|      .|  :|:|.::..:|.:
Yeast    27 KGRVKFIGETQFAKGIWYGIELDKPLGKNDGSANGIRYFDIDLKKANSNGGYYGLFCKKDTLQFY 91

Human    98 EDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAG 162
            :          ||.....:|.......|.|
Yeast    92 K----------PDDDEHSLLNGNAAQETIK----------------------------------- 111

Human   163 ASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDL 227
                                                                    .|:.:...|
Yeast   112 --------------------------------------------------------NLQVKCESL 120

Human   228 EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKER 292
            ..||..::::..|.|..:::|..::..|      .||:..    |.:.:||.:.|........:.
Yeast   121 ASKLNKIKIENHELKTSVEKLSTNETVL------LSKISR----LDKLVKELKVENGNMKTHLDN 175

Human   293 YMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 357
            : ..:.|.:|::....|||....||:..||..::..|...|:.   :::.:..:||.
Yeast   176 F-NHLLDASDSVMAPDLDKGTLLERSHLLQGLLDQTKLSYDKA---MKVQEDLLEEN-------- 228

Human   358 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAEST 422
               .||.|:||                         ::.||..:|.:          :|.|..:|
Yeast   229 ---TQLLEENA-------------------------VLSKKISDLGL----------QLQQTNNT 255

Human   423 IDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 487
            |.:|..|::|...:..:|:.||:.|:.|...::.|...:.:|:|..::::.|:....:.|.|||.
Yeast   256 IGDLALQIEAQSKSSNIVDKLTNDNILLTSNIKALNNELEELQAKEKLDENLRITYEQLEQELRL 320

Human   488 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 552
            ||.       ..|..:|..:|....|   |::..:|.|.|:.:.
Yeast   321 QLS-------NLQSALENEKEIAGTY---IEENSRLKATLESIE--------------------- 354

Human   553 FDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLIC 617
                   |:|....:::|:::..::
Yeast   355 -------AKTSHKFQSLELKVNTLQ---------------------------------------- 372

Human   618 KAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVY 682
             .||.:.:..:||                                       |:         :|
Yeast   373 -EELYQNKLLKKF---------------------------------------YQ---------IY 388

Human   683 KKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVE-----PLTKAIKYYQHLYSIHLAEQPEDC 742
            :....  |.::|....|.:|.|::..:...:..|:|     .:..:|.|..|:|:|
Yeast   389 EPFAQ--PHLAALSSQLQYLAEVIESENFGKLENIEIHIILKVLSSISYALHIYTI--------- 442

Human   743 TMQLADHIKFTQSALDCMSVEVGRL---------RAFLQGGQEATDIALLLRDLETSCSDIRQFC 798
             ....||::.|   |.|..|.:..:         |.|....:.|..|...|.|.:....|:....
Yeast   443 -KNTPDHLETT---LQCFKVNIAPISMWLSEFLQRKFSSKQETAFSICQFLEDNKFLDKDVTLIL 503

Human   799 KKIRRRMPGTDAPGIPAALAF-----GPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 858
            |.:...:..|    :|..|||     ....:|||  |                    ||..|.|.
Yeast   504 KILHPILETT----VPKLLAFLRTNSNFNDNDTL--C--------------------LIGSLYER 542

Human   859 EGLLVAALEEL-----AFKASEQIYGTPSS------------SPYECLRQSCNILISTMNKLATA 906
            ...|:|.:::|     ..|...:::..||.            |....|||... .||::.||...
Yeast   543 SLSLIARIDKLIGKEEISKQDNRLFLYPSCDITLSSILTILFSDALFLRQDYK-RISSLKKLEVF 606

Human   907 MQEGEYDAERP---PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSE 968
            .|..|...|..   |.:|          ..:.:|:|.        :..|||...|..:..:.|:|
Yeast   607 FQGIESLLENITIFPEQP----------SQQTSDSES--------QCNIKEGNFSNSLLSDRLNE 653

Human   969 ANVR-----------LSLLEKKL------DSAAKDADERIEKVQTRLE--------ETQALLRKK 1008
            .|:|           |:.||.|:      |...|..:|.|:.::..|.        :|:.|.:.|
Yeast   654 ENIRLKEVLVQKENMLTELETKIKIIIGRDLERKTLEENIKTLKVELNNKNEENCGKTEILNKLK 718

Human  1009 EKEF------------------EETMDALQADIDQLE-----AEKAELKQRLNSQSK 1042
            |:.|                  ..|::.:..|.::::     :|..||::.:..|.|
Yeast   719 EENFNLVNRLKNMELKLYQIKDNNTLNKIYLDREKVDRVNLVSEIMELRETIRRQIK 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1	NP_004073.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		CAP_GLY	30..94	CDD:279625	23/60 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..223		6/122 (5%)
		FAM76	<135..292	CDD:292665	14/156 (9%)
		CCDC144C	227..547	CDD:291576	64/319 (20%)
		PCRF	246..>342	CDD:305100	19/95 (20%)
		CASP_C	314..>455	CDD:285395	28/140 (20%)
		Dynactin	525..805	CDD:289240	37/293 (13%)
		Interaction with HPS6. /evidence=ECO:0000269|PubMed:25189619	911..1278		35/183 (19%)
		FAM76	<952..1034	CDD:292665	26/129 (20%)
NIP100	NP_015151.1	NIP100	12..828	CDD:227569	192/1097 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18916
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100