Protein Alignment DCTN1 and Dred

DIOPT Version :10

• Sequence 1: NP_004073.2
• Gene: DCTN1 / 1639
• HGNCID: 2711
• Length: 1278
• Species: Homo sapiens
• Sequence 2: NP_649124.1
• Gene: Dred / 40124
• FlyBaseID: FBgn0036882
• Length: 1339
• Species: Drosophila melanogaster
• Alignment Length: 1467
• Identity: 380/1467 - (25%)
• Similarity: 608/1467 - (41%)
• Gaps: 390/1467 - (26%)

Human    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87
            |.|.|::|.||||.||..:|.|||||.|.||.|.|.||:|||..|||:|:|.|..||.|....|:
  Fly     3 SPRELKLGQRVEVTGKNLQGKVAYVGRTNFAAGLWYGVVLDEPLGKNNGSVHGSIYFKCPTNCGL 67

Human    88 FVRQSQI----------------QVFEDGA----------------------------------- 101
            |||..|:                ::..|||
  Fly    68 FVRAQQLVRIAELPKGGDNRKADEMQRDGARAKLSRRSGSGKSVEEQDNQREQQASTSGKVKATS 132

Human   102 DTTSPE------------------------------------TPDSSASKVLKREGTDTTAKTSK 130
            .|.||:                                    |.:||......:|..:.|....|
  Fly   133 STPSPQHKNRNTHSSMETSLAKTSGKFLATHQQPLQLPKNPVTCESSVRNSQSKETGEVTLSPKK 197

Human   131 LRGLKPKKAPTARKTT-TRRP------------------------KPTRPASTGVAG------AS 164
            ...::..|..:.::|. |.:|                        .|..|..|...|      ||
  Fly   198 SSDIEQSKKHSQQETNETNQPASKEVEPKNENELQSTEAANSMLDTPVNPLQTSTIGQLPPQKAS 262

Human   165 SSLGP-------SGSASAGEL-----SSSEPST------PAQTPLAAPI---------------- 195
            :.|.|       ..|.|..:|     |..:|:|      .||..||.|:
  Fly   263 AQLTPPPLTCNQRRSTSYTQLRPTRISQPKPTTAQAQSSTAQLTLAMPVPLALAPKRSKTSMSPT 327

Human   196 ------------------------IPTPVLTSPGAV-PPLPSPSKEEEGLRAQVRDLEEKLETLR 235
                                    .|.|.|.:|.:| |||.:|         ::|.|.|:|:.||
  Fly   328 SSIKRVAPAAFVEPRFLEILRPQFTPGPALRTPSSVAPPLDNP---------ELRQLREELQLLR 383

Human   236 LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 300
            .:::|||.||.|||:.:|..||:.|:||::..||..|||.|:.:|.|.:||.:...:...|:.:.
  Fly   384 GQKSEDKLKLLELERMRIHNEQLMEFKSQIMAQQVLLQRELQRSRHELREAQDVSSKLKRELDEI 448

Human   301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK------------GSDG 353
            |::||:.||||||||||.|:||.|:|..:||.|||:.|:||||||.||:            || |
  Fly   449 AESIELLTLDKEMAEERMETLQMELEMAQERNDELSLDVEILKAEQEEQQGQRIEKSEKQIGS-G 512

Human   354 AA--SSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEEL 416
            ..  |:.:..:||:.|.||::.:||:||..:.|||...:..|.:|.|:.|:..::..:|.|...:
  Fly   513 VTNQSAGEFLRLEQYNQRLRETVVRLRDTLAEEKQIGQRTHKELETKHSEINELKSIKELLSRRV 577

Human   417 SQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARET 481
            ...|..:.:|||||||:||||.||..|....|.||::|:.|.:.|.:|||:.::.::|.|:.:|.
  Fly   578 DNMEMQLMDLKEQVDASLGAEAMVTQLASLKLELEDRVKLLEDEVNELEALEQIQEQLIESNQEL 642

Human   482 ELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQ--------------DVNR 532
            |.:|||::|.....|:..:::..||.|::.|...||.|:|.|...||              |.:.
  Fly   643 ETDLREEIDKLSGHVKILEQQKNAAMESLYDRDVTIMKFRDLVRQLQEQLQLRADGTLSIEDFSS 707

Human   533 ELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFL 597
            ...:|||....:.|.      |::..|:.:||:.:|:|.:::.:|:....:|:..:.||:|:.||
  Fly   708 ANESQQEDGSNQSQT------DYQHIFSVSKAYGRALEQQIKTVELRLQRQHLEHVLAFVPEQFL 766

Human   598 RPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 662
            ..||:||.|||:||:.|:..|..::.:...|||..:..........|.:.::..|.:..:|.|..
  Fly   767 LRGGEHDVVLVMLLLERMNEKLTIVCQAINEKFPTACEFGRDAIFEGYSVQRYIFRSQCLYLLKS 831

Human   663 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 727
            ||..|.::.|.|:.|..::.........::.|.|:.||..:.||...||||..|.||:.:.:.|
  Fly   832 LQLVLQQFRHGLTHCDYELCTHAAIYRSDLDAQEQQLDEFVRLLKTGQLDEHTNCEPIQRVLHY- 895

Human   728 QHLYSIHLAEQPEDCTMQLADH-------IKFTQSALDCMSVEVGRLRAFLQGGQEAT-DIALLL 784
              :..:|....|....::|.|.       |:..::.||.::...|.:...:|.|.|.| ..:.:.
  Fly   896 --VSGLHQNLMPPQTLVELLDEQQLYEALIEVYEAGLDAVNANAGLMHTIIQLGHEQTASFSCMQ 958

Human   785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAA 849
            ..:|.||:. :|..||::|::.|:..            .|.|.:.|.::
  Fly   959 MLMEQSCAH-KQKLKKLQRKLSGSKT------------ASWTGMQCARY---------------- 994

Human   850 QLIAPLAENEGLLVAALEELAFKASEQIYG------------------TPSSSPYE-----CLRQ 891
            |.|....|..|.|:..|...|.:||:...|                  .||....|     ...|
  Fly   995 QRIMEANEALGTLIRLLGCTAREASKDSNGGIAHEKLWRMLVLNYNKFAPSQEAEEPREVDAYSQ 1059

Human   892 SC-NILISTMNKLATAMQEGEYDAE--RPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIK 953
            .| .:|....::|...:...:.:.|  |.|: ...::.|||.::....|.:.|.|.:.:||..||
  Fly  1060 RCMQLLEEQFDELFALLDSTDVNTEYVRHPT-CNTLQERAAQVKRHYEDVKNLELTVAEREKEIK 1123

Human   954 ELKKSLKIKGEELSEANVRLSLLEKKLD------SAAKDADERIEKVQTRLEETQALLRKKEKEF 1012
            .||.:.|:|.::.||..||..:.||:|.      :...:|.|::|         |::| .||...
  Fly  1124 SLKYTAKMKQQDYSELQVRKEMAEKQLSKQCHVLAGFAEAVEQLE---------QSIL-AKEAAL 1178

Human  1013 EETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQA 1077
            .:.::.|...:..||..:...|::..:.|               |.|.|......::
  Fly  1179 GQALNMLADKLTSLEQSQEHWKEQQQADS---------------ACLTSTTISSNRE-------- 1220

Human  1078 PGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSI---LKGAQMKASLASLPPLHVAKLSHEGP 1139
                                  |.:....|:.|.|:   |:|::|:.:.|:|.||||.:
  Fly  1221 ----------------------MNMLHQALRQERSLRVELQGSEMRKTFAALEPLHVPQ------ 1257

Human  1140 GSELPAGALYRKTSQLLETLNQLSTH---THVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEK 1201
                 ||:  ::.:.|.:.|..|...   .|                  :|..|..:.....:|.
  Fly  1258 -----AGS--QELTDLEKDLRSLKNQWLLAH------------------LEMGAAGRQRRSEIEL 1297

Human  1202 LKDEVLKET----VSQRPGATVPTDFATFPSSAFLRA 1234
            ....||:..    .:|.|.....|||..|.:....||
  Fly  1298 QGSRVLRHIFHTYCTQHPHRAKNTDFGLFITEDLRRA 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1	NP_004073.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		1/1 (100%)
		CAP_GLY	29..94	CDD:460154	36/64 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..223		43/283 (15%)
		PHA03247	<101..220	CDD:223021	42/279 (15%)
		SMC_prok_B	220..>540	CDD:274008	132/347 (38%)
		Dynactin	527..805	CDD:463591	77/299 (26%)
		Interaction with HPS6. /evidence=ECO:0000269|PubMed:25189619	911..1278		71/342 (21%)
		Smc	<926..>1046	CDD:440809	33/125 (26%)
Dred	NP_649124.1	CAP_GLY	9..74	CDD:460154	36/64 (56%)
		Metaviral_G	171..306	CDD:462833	26/134 (19%)
		Smc	<373..>704	CDD:440809	129/331 (39%)
		Dynactin	688..967	CDD:463591	73/287 (25%)
		Smc	<1092..>1305	CDD:440809	60/298 (20%)