Protein Alignment DCTN1 and DCTN1-p150

DIOPT Version :10

• Sequence 1: NP_004073.2
• Gene: DCTN1 / 1639
• HGNCID: 2711
• Length: 1278
• Species: Homo sapiens
• Sequence 2: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1281
• Identity: 435/1281 - (33%)
• Similarity: 699/1281 - (54%)
• Gaps: 101/1281 - (7%)

Human    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87
            |.:.|:||:|||:.||...|||||||.|.||.||||||:|||.||||.|:::|::||.|||..|:
  Fly     2 SEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGM 66

Human    88 FVRQSQIQVFE------------DGADTT----------SPETPDSSASKVLKREGTDTTA---- 126
            |||.:|:::.|            .||..|          |..|..||:.:.|....|..|.
  Fly    67 FVRPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSE 131

Human   127 KTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASA--------GELSSSEP 183
            :|:....:.|:|: .|.:.:..:..|:...:.|...||...|.:..||:        |.|...:|
  Fly   132 RTASSSSIGPRKS-LAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKP 195

Human   184 S-TPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKE 247
            . ||:| ||.:|....|..:.......|....|....|:||:.||.||||||:.:|.|||.:|:|
  Fly   196 QFTPSQ-PLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLRE 259

Human   248 LEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 312
            .:|.|||.||:||:::|:...||.||:.|..|::|||:|:||||::.:||||.||.:||.|||||
  Fly   260 FDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKE 324

Human   313 MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK-----------GSDGAASSYQLKQLEEQ 366
            ||||:|::||.|:|:.|||::||..|||:|::|::.|           |.....|:|:.||||:|
  Fly   325 MAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQ 389

Human   367 NARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431
            |.|||:.|||:||||:.:|.:..||.|.:|.|..|:..:.:.:|:|..::.:.|:.:.:|:||||
  Fly   390 NIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVD 454

Human   432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
            ||||||||||.|.::.:.||:||:.|.|.:..|||:.|::::|.|:..|.||:|||:||:|....
  Fly   455 AALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAK 519

Human   497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP-----PETFDFK 556
            :|..:..:||.||:.|..|||.|:|:|...|.|...||.::..::.:...|.|     .||.|:|
  Fly   520 KEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYK 584

Human   557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAEL 621
            ..|||:||:.:||:::|||:|::|||.|:.:||||||:||:..|||||.:||:||:.|::.|.::
  Fly   585 QMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDI 649

Human   622 IRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686
            :..|.:|:|...:..:.....:|.|.:|.:|...|::.:..||..||:..:.|:.|..|...:.|
  Fly   650 VVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAG 714

Human   687 SLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA-EQPEDCTMQLADHI 750
            |..|||.|.|:.:|.:||||..:||||....:.:.|.:.::..:.|:.|| ||..:....:.|.:
  Fly   715 SSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCV 779

Human   751 KFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPA 815
            ....:|.:.:..:....:..:|.....:|..||::.|..:...:||..|.|:||:| :|...|.:
  Fly   780 ASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLP-SDQHVIKS 843

Human   816 ALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE-----LAFKASE 875
            .|:  ....:.:....::::.:::.:.:....:...|....|::......|.:     |...:.|
  Fly   844 GLS--QHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCE 906

Human   876 QIYGTPSSSP---YECLRQSCNILISTMNKLATAMQEGEYD----------AERPPSKPPPVELR 927
            :||......|   ::.|....|   |.:..:|..:.:.|||          .::..:...|:..|
  Fly   907 RIYEQDDRGPTQNFKTLLAQAN---SDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQR 968

Human   928 AAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 992
            |..::.::.....|...||:||..:|:||.:.|:|..||||..:|..|.||||.....:.:..::
  Fly   969 AQLIKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVD 1033

Human   993 KVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAEL--KQRLNSQSKRTIEGLRGPPPSG 1055
            |.:.:.|||...|:.||||||||||.||:|||.||:||::|  |.:|||.:.:...|.....|..
  Fly  1034 KWKQKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHN 1098

Human  1056 IATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMK 1120
            |:  :||      .....||.:..|...|  ...:|::.:::..::...:|.:::...|:...|:
  Fly  1099 IS--LSG------NTSTAPGISNVSYSAP--AGTAPVVAEEVELLKNAFNQERNQRLRLQAQDMR 1153

Human  1121 ASLASLPPLHVAKLSHEGPGSELPA--GALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSA 1183
            |.|:...||||.:...:    .:.|  ..|.|.....:.:|.|:.:...|...||....|    .
  Fly  1154 AKLSQFEPLHVPQPQDQ----RITALESELTRMKHAWVLSLLQVRSQDSVNSGTRIDAVA----L 1210

Human  1184 QLMEQVAQLK-SLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPS 1228
            |...|...|| .:|....:|..::|.|.:.::|.......||:||:
  Fly  1211 QRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPT 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1	NP_004073.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		1/1 (100%)
		CAP_GLY	29..94	CDD:460154	41/64 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..223		34/145 (23%)
		PHA03247	<101..220	CDD:223021	32/141 (23%)
		SMC_prok_B	220..>540	CDD:274008	155/330 (47%)
		Dynactin	527..805	CDD:463591	93/283 (33%)
		Interaction with HPS6. /evidence=ECO:0000269|PubMed:25189619	911..1278		96/333 (29%)
		Smc	<926..>1046	CDD:440809	51/121 (42%)
DCTN1-p150	NP_524061.1	CAP_GLY	8..73	CDD:460154	41/64 (64%)
		NIP100	13..>272	CDD:227569	95/260 (37%)
		SMC_prok_B	<219..>497	CDD:274008	130/277 (47%)
		Dynactin	550..834	CDD:463591	93/283 (33%)
		Smc	<965..>1080	CDD:440809	48/114 (42%)