DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irx2 and achi

DIOPT Version :9

Sequence 1:	NP_034704.1	Gene:	Irx2 / 16372	MGIID:	1197526	Length:	474	Species:	Mus musculus
Sequence 2:	NP_001286352.1	Gene:	achi / 36373	FlyBaseID:	FBgn0033749	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	269	Identity:	66/269 - (24%)
Similarity:	100/269 - (37%)	Gaps:	57/269 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse   119 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAP 183
            |.|..:.:...||.||.|||.|.||:..||..|:....:|:.||..||.|||||:..|
  Fly    97 RGNLPKTSVKILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPE------- 154

Mouse   184 RNKSEDEDEDEGDASRSKEESSDKAQDGTETSAEDEGIS-LHVDSLTDHSCSA--ESDGEKLPCR 245
            ..:.|..|......||..::.|......:...|...|.: .|....::....|  |.||
  Fly   155 MIRREGNDPLHFTISRRGKKVSPNCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDG------ 213

Mouse   246 AGDALCESGSECKDKFED---------LEDEEDEEDECERDLAPPKPVTSSPL------TGVEAP 295
            ||: :.|..:.....||.         ::.|.:.||..  ..:..:.:.::|:      :.::|.
  Fly   214 AGE-IHEGIANVLTNFEQYVQGPNGQMVKMEPEYEDSV--IYSWQQAIANNPMGFQSLHSSLQAT 275

Mouse   296 LLSPAP-----EAAPRG----GSGGKTPLGSRTSP----------GAPPP----ASKPKLWSLAE 337
            ::....     :||..|    ||||.....|.:||          |..||    ..||:......
  Fly   276 MIDKIKNYQMRKAAAIGGSAVGSGGAGGSSSNSSPATSILPYSLFGQLPPEFDDEEKPRPPKRVR 340

Mouse   338 IATSDLKQP 346
            ..|...|.|
  Fly   341 TRTVAAKSP 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irx2	NP_034704.1	COG5576	<115..217	CDD:227863	31/97 (32%)
		Homeobox_KN	133..172	CDD:368670	19/38 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..220		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..373		24/123 (20%)
		IRO	325..342	CDD:214716	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..461
achi	NP_001286352.1	Homeobox_KN	111..150	CDD:283551	19/38 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900