DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Irs1 and chico

DIOPT Version :9

Sequence 1:NP_034700.2 Gene:Irs1 / 16367 MGIID:99454 Length:1231 Species:Mus musculus
Sequence 2:NP_001188772.1 Gene:chico / 64880 FlyBaseID:FBgn0024248 Length:968 Species:Drosophila melanogaster


Alignment Length:1088 Identity:254/1088 - (23%)
Similarity:416/1088 - (38%) Gaps:295/1088 - (27%)


- Green bases have known domain annotations that are detailed below.


Mouse     1 MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIP 65
            |||..| ||.:   ..|||:|.|:|.|:||||...:.... ||||||:.|||:..::. |||.|.
  Fly     1 MASISD-DGMA---LSGYLKKLKTMKKKFFVLYEETSTSA-ARLEYYDTEKKFLQRAE-PKRVIY 59

Mouse    66 LESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGG 130
            |::|||||:|.|:|::.::.|.:||..|.|..::|.:...|...||.|..               
  Fly    60 LKNCFNINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQR--------------- 109

Mouse   131 SCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSE 195
            :.:.|:|...:    .||        .||||:::.||:.:...:.|.|..|||||:::||.:..|
  Fly   110 NIANSNGTAHS----PYD--------HVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPE 162

Mouse   196 --------AAAVVLQLMNIRRCGHS--ENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILE 250
                    .|::.:.|..||||||:  :..|::|:||.:|.|.|:.||:.|::.:|.|||.|||.
  Fly   163 KTPNGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILS 227

Mouse   251 AMRAMSD---------EFRP-------RSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSR 299
            ||.|.::         :.||       |.:|.|::..|.||:|.:.::       ||..|..|| 
  Fly   228 AMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQN-------SQNSLELRS- 284

Mouse   300 TESITATSPASMVGGKPGSFRVRASS--DGEGTMSRPASVDGSPVSPSTNRTHAHRHRG------ 356
                 .:||.:.     |..|.|..|  ...||:|.           |:|:|:...:.|      
  Fly   285 -----CSSPHNY-----GFGRERCDSLPTRNGTLSE-----------SSNQTYFGSNHGLRSNTI 328

Mouse   357 -SSRLHPPLNHSRS--IPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDG 418
             ..|.|....||.|  ..|| .|||.|..|.:|:..|  ..:||.|......|||.:.....:..
  Fly   329 SGIRPHSTNKHSNSPTFTMP-LRCSESEESSISVDES--DDNGSFSHYRLNTRSSETAIPEENID 390

Mouse   419 GFISSDEYGS-----------------SPCDF-----RSSFRSVTPDSLGHTPPARGEEELS--- 458
            .|.|::.:..                 :|.|.     ::..:.:...||....|....|:|:   
  Fly   391 DFASAELFSKVTEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHASEKLAKDF 455

Mouse   459 -----NYIC-------MGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAAD 511
                 |..|       :|.|...........::...|.|.:| :...::|:...:|      ..|
  Fly   456 DLDSDNQCCRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNR-VRAYSVGSKSKIP------RCD 513

Mouse   512 LD--------------NRFRKRTHSAGTS--PTISHQKTPSQSSVASI------EEYTEMMPAAY 554
            |.              ||.:......|||  .:.:.||..:.:.:.|:      :..:::|...:
  Fly   514 LQRVVLVEDNKHEFTANRSQSSITKEGTSYGSSANRQKKSTSAPLLSLKNQINSDRMSDLMEIDF 578

Mouse   555 PPGGG-------SGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSN--LHTDDGYMP 610
            .....       ....:|.|..:.|..........|.:|...::...:....:|  :.::|||:.
  Fly   579 SQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAITSEDGYLE 643

Mouse   611 MSP---------GVAPVPSNRKGNGDYMPMSP-KSVSAPQQIINPI----------RRHPQRVDP 655
            |.|         ...|:...:....||....| .:.:||...:|.|          |..|.|.:.
  Fly   644 MKPVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWREQPSRSEE 708

Mouse   656 NGYMMMSP--------------SGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTN--------GV 698
            .  ...||              |.|.|.|:...:........|.|.........:        .:
  Fly   709 K--KSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLADKIVENNNLDI 771

Mouse   699 GGHHTHALPHAKPPVESGG-GKLLPCTGDYMNMSPVG--------DSNTSSPSECYYGPEDPQHK 754
            |||....|.|:   :.|.. .::...:.|:...:..|        ||:..| |:.|   :...||
  Fly   772 GGHEEKKLVHS---ISSEDYTQIKDKSNDFTKFNEAGYKILQIKSDSSLIS-SKLY---QKGIHK 829

Mouse   755 PVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSST-----------SS 808
            .     :|.||.:.|:......:.|                ||||..|||.|           ::
  Fly   830 D-----NLERSQRLTESVNTIPDNA----------------TATAVSSSSLTKFNINSAKPAAAA 873

Mouse   809 DSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTAAQTNSRLARPT--RLSLGDPKASTLPRVRE 871
            ||...|...:.|:        ::||   .:.::..::::||:::|.  ..||..|..|.....:.
  Fly   874 DSRSTGTDPSTPQ--------NILQ---IKDLNFPSRSSSRISQPELHYASLDLPHCSGQNPAKY 927

Mouse   872 QQQQQQSSLHPPE---PKSPGEYVNIEFGSGQPGYLAGPATSRSSPSV 916
            .::..:.|  ||.   |:....|..|:|....        :|.||.::
  Fly   928 LKRGSRES--PPVSACPEDGNTYAKIDFDQSD--------SSSSSSNI 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irs1NP_034700.2 Mediates interaction with PHIP. /evidence=ECO:0000250 3..133 47/129 (36%)
PH_IRS 11..118 CDD:269959 43/106 (41%)
PH 17..110 CDD:278594 40/92 (43%)
PTB_IRS 155..258 CDD:269915 44/121 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..425 49/194 (25%)
YXXM motif 1 460..463 1/9 (11%)
YXXM motif 2 546..549 0/2 (0%)
YXXM motif 3 608..611 1/2 (50%)
YXXM motif 4 628..631 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 651..720 15/91 (16%)
YXXM motif 5 658..661 0/2 (0%)
YXXM motif 6 727..730 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..985 33/167 (20%)
GRB2-binding. /evidence=ECO:0000250 891..893 1/1 (100%)
YXXM motif 7 935..938
YXXM motif 8 983..986
YXXM motif 9 1006..1009
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1231
chicoNP_001188772.1 PH_IRS 7..112 CDD:269959 45/124 (36%)
PH 25..104 CDD:278594 33/80 (41%)
PTB_IRS 122..235 CDD:269915 46/120 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167842362
Domainoid 1 1.000 94 1.000 Domainoid score I7442
eggNOG 1 0.900 - - E1_28N3R
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001178
OrthoInspector 1 1.000 - - otm43342
orthoMCL 1 0.900 - - OOG6_105771
Panther 1 1.100 - - O PTHR10614
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4611
SonicParanoid 1 1.000 - - X1499
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.820

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