Protein Alignment ACE and Ance-4

DIOPT Version :10

• Sequence 1: NP_000780.1
• Gene: ACE / 1636
• HGNCID: 2707
• Length: 1306
• Species: Homo sapiens
• Sequence 2: NP_610442.2
• Gene: Ance-4 / 35909
• FlyBaseID: FBgn0033366
• Length: 609
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 168/613 - (27%)
• Similarity: 289/613 - (47%)
• Gaps: 53/613 - (8%)

Human   639 GIDLVTDEA----EASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLK 699
            ||...|..|    ||..||.:........:||.|...::.|.....:.....|....:||...:.
  Fly    12 GIGCATAAANIDLEAKTFVNQSSDRYYRFYNEIAAETYSANNEEDFDALFSKLNNVKRIAEELVS 76

Human   700 YGTQARKFDVNQLQNTTIKRIIKKVQ----------------DLERAALPAQELEEYNKILLDME 748
            ...||..:|::::::...|..:::::                .:..|||.....::      |:|
  Fly    77 ISRQAATYDLDRIRSPQTKMALQELRTAGDLFVLGDDYFSSVQMNLAALQTLSTDK------DIE 135

Human   749 TTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGR-AILQFYPKYVELINQA 812
            .....|.:.:.:.|.|...||:..::.:|:..::|.:.||.||||... |.|.|| ..|:...:|
  Fly   136 PYLGGANMPNEDDSPLAYFPDIQKIVQSSKDADELKYYWEAWRDKNQLWASLNFY-TIVQSYQRA 199

Human   813 ARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPA 877
            |::. .|.....| ..|::..:.|.:|:...||:|.|..|||:||:.||:.||:..:||.||||.
  Fly   200 AKIL-EVPVHKLW-YRYDSQEMLQQMEQAMTELRPAYQQLHAFVRQELHKKYGSDVVNLNGPIPD 262

Human   878 HLLGNMWAQTWS--NIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEF 940
            ||...:..|.|:  :|.:...|....|..|...:.|    |.:.|..|:::|:||||..|:..||
  Fly   263 HLFQQVLEQAWASGSILEDYYPRAQLPEFDEYVSHL----TAKTMVNESENFYTSLGFEPLSAEF 323

Human   941 WNKSMLEKPT-DGREVVCHASAWDF----YNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYK 1000
             :|:.|::|. |.....|..|.:|.    |      :..|..|:...|:..|..|..:.|..|..
  Fly   324 -HKNQLKEPNQDSPNDDCRPSIFDLTPHVY------LMYCEKVSFRKLMQYHSHMARVYYAQQKS 381

Human  1001 DLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPF 1065
            .||....:..|..|  |:|:.:.||.|:|.||.. ..|:.|..|:...::.|.:||:..|..||.
  Fly   382 HLPSYYFKAYNLEF--AVGEAVVLSASSPAHLTG-RRLAKEVLSETALMSRLFRMAIHTILSIPL 443

Human  1066 SYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPY-IRYF 1129
            .|:..:....:.:.::..:..|:.:|.|..::.|:..|..|::|..|...||::.....: .:.|
  Fly   444 YYVHTKVMHDLLNDTVDMDTVNKHYWRLMEQHAGIEAPSDRSEGAIDFPYKFYVNIDQSFQTQKF 508

Human  1130 VSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAM-QLITGQPNMS 1193
            :|.::.:||:...|:.:.:.||||.||.|.|...|..|...|.||.::||.:.: :::.....:|
  Fly   509 ISEVLGYQFYREFCKKSYNRGPLHNCDFYGSLAVGNDLKAMMSLGSTKPWKQVVGKILPNNTGLS 573

Human  1194 ASAMLSYFKPLLDWLRTENELHGEKLGW 1221
            :.|:|.|::|:||||...|:....|:||
  Fly   574 SLALLEYYQPVLDWLNKYNKDANSKIGW 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACE	NP_000780.1	Peptidase_M2	40..623	CDD:460196
		Peptidase_M2	643..1221	CDD:460196	164/607 (27%)
		Juxtamembrane stalk. /evidence=ECO:0000269|PubMed:11274151	1215..1256		3/7 (43%)
Ance-4	NP_610442.2	M2_ACE	29..592	CDD:341055	158/585 (27%)