Protein Alignment ACE and Ance

DIOPT Version :9

• Sequence 1: NP_000780.1
• Gene: ACE / 1636
• HGNCID: 2707
• Length: 1306
• Species: Homo sapiens
• Sequence 2: NP_001285915.1
• Gene: Ance / 34805
• FlyBaseID: FBgn0012037
• Length: 615
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 265/593 - (44%)
• Similarity: 364/593 - (61%)
• Gaps: 9/593 - (1%)

Human   642 LVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARK 706
            ||.:|.:|.:::|..::......|...||.|.|.:|||.|..|...:.:.::|....:..:...|
  Fly    18 LVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTK 82

Human   707 FDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGS--C-LQLEP 768
            |.....|:..:||..|.:..|..||||..:..|....|..||:.::...||....|  | |.|:|
  Fly    83 FQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDP 147

Human   769 DLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPS 833
            ::..|::.||.:|:|.:.|..:.||||.|:...:.:||||..:||:||.:....::|...||..:
  Fly   148 EIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDT 212

Human   834 LEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPF 898
            .||.||.:|.:::|||..:|.|||..|.:|||...::..||||.|||||||||.||.|.|:|.||
  Fly   213 FEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPF 277

Human   899 PSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWD 963
            |..|.:|.:..|.|||:||.:||:..||||||:.|..:|.:||:||::|||||||::||||||||
  Fly   278 PEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWD 342

Human   964 FYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVST 1028
            ||...|.||||||.|..:.|...|||:||||||:||:..|...|.|||||||||:||||:|||||
  Fly   343 FYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVST 407

Human  1029 PKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSL 1093
            ||||..:.||......||..||.|...|||||.|:||::.:|::||.:|.|.:.|.|:|..:|.|
  Fly   408 PKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKL 472

Human  1094 RLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTG------PL 1152
            |.:|.|:.|||.|::.|||..||:||.:.|.|:||.|||||||||:::.|..||...      ||
  Fly   473 RDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPL 537

Human  1153 HKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGE 1217
            ..||||.|..||......:.:|.|:|||:|::...|:..||..|:..||:||..||..||..:..
  Fly   538 DNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNV 602

Human  1218 KLGWPQYN 1225
            .:||...|
  Fly   603 HIGWTTSN 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACE	NP_000780.1	Peptidase M2 1	30..630
		Peptidase_M2	40..623	CDD:279709
		Peptidase M2 2	631..1232		265/593 (45%)
		Peptidase_M2	643..1221	CDD:279709	261/586 (45%)
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	261/586 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I284
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm40361
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2384
SonicParanoid	1	1.000	-	-		X1436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760