Protein Alignment ACE and Acer

DIOPT Version :10

• Sequence 1: NP_000780.1
• Gene: ACE / 1636
• HGNCID: 2707
• Length: 1306
• Species: Homo sapiens
• Sequence 2: NP_477195.1
• Gene: Acer / 34189
• FlyBaseID: FBgn0016122
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 246/599 - (41%)
• Similarity: 348/599 - (58%)
• Gaps: 10/599 - (1%)

Human   632 LPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANH 696
            ||.....|........||.:|.|..:...:..::|...:.:|||||:|....:.:::...:.|..
  Fly    17 LPHGLSMGNSCSASVLEARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVYARNAEL 81

Human   697 TLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC-HPN 760
            ..:...|.:..|..|.::..|:|..:.:..|..:||.|.:.......:..|:|.|:.|||| :.|
  Fly    82 NKRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNYATATVCSYTN 146

Human   761 GS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGD 823
            .| | |.|||.:...::.||...:|.|.|..|.||:|..:.|.:.:||.|..:|::|||:....|
  Fly   147 RSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRSYAD 211

Human   824 SWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTW 888
            .|...||.|..|:.|:..|::|.|.|..||.|||..|.:|||...:..||.||..||||||.|:|
  Fly   212 YWVQFYEDPDFERQLDATFKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNIPISLLGNMWGQSW 276

Human   889 SNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGR 953
            :.:.||..|:|..|.:|....|.|||:|.:::|:..|.||.|||:..:||.|||.|:|.:| |.|
  Fly   277 NELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSFWNLSVLTRP-DDR 340

Human   954 EVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAI 1018
            .|||||||||||...|.|||.||.|:.....|.|||:|||||::||:..|...|...|||||||:
  Fly   341 HVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAVYRGAPNPGFHEAV 405

Human  1019 GDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITK 1083
            |||:||||.:.|||.::.|:.:....::..||.|.|.||.||.|:||.|.||::|:.||...:.:
  Fly   406 GDVIALSVMSAKHLKAIGLIENGRLDEKSRINQLFKQALSKIVFLPFGYAVDKYRYAVFRNELDE 470

Human  1084 ENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH 1148
            ..:|..:|.:|.::.|:.|||.||:.||||.||:||.:.|.|:|||.:.|.|||||:|||:.||.
  Fly   471 SQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQFQFHKALCRKAGQ 535

Human  1149 TGP------LHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDW 1207
            ..|      |..|||:.||.||:.|:..:..|.||.|.|.::..||:..|..:|:|.||:||..|
  Fly   536 YAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDPAALLEYFEPLYQW 600

Human  1208 LRTENELHGEKLGW 1221
            |:.||...|..|||
  Fly   601 LKQENSRLGVPLGW 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACE	NP_000780.1	Peptidase_M2	40..623	CDD:460196
		Peptidase_M2	643..1221	CDD:460196	241/586 (41%)
		Juxtamembrane stalk. /evidence=ECO:0000269|PubMed:11274151	1215..1256		4/7 (57%)
Acer	NP_477195.1	Peptidase_M2	33..614	CDD:460196	241/581 (41%)